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Open Access 01-11-2010

Neonatal Fc Receptor: From Immunity to Therapeutics

Authors: Timothy T. Kuo, Kristi Baker, Masaru Yoshida, Shuo-Wang Qiao, Victoria G. Aveson, Wayne I. Lencer, Richard S. Blumberg

Published in: Journal of Clinical Immunology | Issue 6/2010

Abstract

The neonatal Fc receptor (FcRn), also known as the Brambell receptor and encoded by Fcgrt, is a MHC class I like molecule that functions to protect IgG and albumin from catabolism, mediates transport of IgG across epithelial cells, and is involved in antigen presentation by professional antigen presenting cells. Its function is evident in early life in the transport of IgG from mother to fetus and neonate for passive immunity and later in the development of adaptive immunity and other functions throughout life. The unique ability of this receptor to prolong the half-life of IgG and albumin has guided engineering of novel therapeutics. Here, we aim to summarize the basic understanding of FcRn biology, its functions in various organs, and the therapeutic design of antibody- and albumin-based therapeutics in light of their interactions with FcRn.

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Title: Neonatal Fc Receptor: From Immunity to Therapeutics
Authors: Timothy T. Kuo
Kristi Baker
Masaru Yoshida
Shuo-Wang Qiao
Victoria G. Aveson
Wayne I. Lencer
Richard S. Blumberg
Publication date: 01-11-2010
Publisher: Springer US
Published in: Journal of Clinical Immunology / Issue 6/2010
Print ISSN: 0271-9142
Electronic ISSN: 1573-2592
DOI: https://doi.org/10.1007/s10875-010-9468-4

ACC 2024 Congress Coverage

Heart Failure Video

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Neonatal Fc Receptor: From Immunity to Therapeutics

Abstract

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

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Other articles of this Issue 6/2010

Prospective Evaluation of Epstein–Barr Virus Reactivation After Stem Cell Transplantation: Association with Monoclonal Gammopathy

A Novel Missense Mutation in the Nuclear Factor-κB Essential Modulator (NEMO) Gene Resulting in Impaired Activation of the NF-κB Pathway and a Unique Clinical Phenotype Presenting as MRSA Subdural Empyema

Profile of Autoantibodies Against Phosphorylcholine and Cross-reactivity to Oxidation-Specific Neoantigens in Selective IgA Deficiency With or Without Autoimmune Diseases

Dermatophagoides pteronyssinus and Tyrophagus putrescentiae Allergy in Allergic Rhinitis Caused by Cross-reactivity Not Dual-Sensitization

Prospective Study of Rapid Relief Provided by C1 Esterase Inhibitor in Emergency Treatment of Acute Laryngeal Attacks in Hereditary Angioedema

Clinical Ramifications of the MHC Family Fc Receptor FcRn

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page