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Published in:

01-08-2012

Type17 T-cells in Central Nervous System Autoimmunity and Tumors

Authors: Hideho Okada, Samia J. Khoury

Published in: Journal of Clinical Immunology | Issue 4/2012

Abstract

Interleukin-17 (IL-17) producing Type17 T-cells, specifically T-helper (Th)17 cells reactive to central nervous system (CNS) autoantigens, manifest a higher migratory capability to the CNS parenchyma compared with other T-cell subpopulations due to their ability to penetrate the blood brain barrier (BBB). In the field of cancer immunotherapy, there are now a number of cell therapy approaches including early studies using T-cells transduced with chimeric antigen receptors in hematologic malignancy, suggesting that the use of T-cells or genetically modified T-cells could have a significant role in effective cancer therapy. However, the successful application of this strategy in solid tumors, such as CNS tumors, requires careful consideration of critical factors to improve the tumor-homing of T-cells. The current review is dedicated to discuss recent findings on the role of Type17 T-cells in CNS autoimmunity and cancer. The insight gained from these findings may lead to the development of novel therapeutic and prophylactic strategies for CNS autoimmunity and tumors.

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Title: Type17 T-cells in Central Nervous System Autoimmunity and Tumors
Authors: Hideho Okada
Samia J. Khoury
Publication date: 01-08-2012
Publisher: Springer US
Published in: Journal of Clinical Immunology / Issue 4/2012
Print ISSN: 0271-9142
Electronic ISSN: 1573-2592
DOI: https://doi.org/10.1007/s10875-012-9686-z

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