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Journal of Assisted Reproduction and Genetics
Published in: Journal of Assisted Reproduction and Genetics 5/2020

01-05-2020 | Assisted Reproduction Technologies

Interleukin 6 in follicular fluid reduces embryo fragmentation and improves the clinical pregnancy rate

Authors: Jie Yang, Xiaoling Yang, Hong Yang, Yang Bai, Hao Zha, Fangjie Jiang, Yushi Meng

Published in: Journal of Assisted Reproduction and Genetics | Issue 5/2020

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Abstract

Purpose

The aim of this study was to evaluate the role of interleukin 6 in embryo development in the in vitro fertilization cycles.

Methods

This was a retrospective cohort study. One hundred and three women undergoing in vitro fertilization and embryo transfer due to a tubal factor were included in the study. The follicular fluid IL-6 levels on oocyte retrieval day from each patient were determined by ELISA. The relationships between follicular fluid IL-6 levels and IVF cycle parameters were investigated.

Results

The levels of follicular fluid IL-6 were not affected by the use of drugs for superovulation or by estrogen. In addition, follicular fluid IL-6 levels did not affect the number of oocytes retrieved or the MII oocyte rate. High levels of follicular fluid IL-6 correlated with a significant increase in the rates of clinical pregnancy. Follicular fluid IL-6 levels did not affect the cell number or the blastomere symmetry of day 3 embryos, but it did significantly reduce the embryo fragmentation rate.

Conclusions

High levels of follicular fluid IL-6 improved the rates of clinical pregnancy and reduce embryo fragmentation.
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Metadata
Title
Interleukin 6 in follicular fluid reduces embryo fragmentation and improves the clinical pregnancy rate
Authors
Jie Yang
Xiaoling Yang
Hong Yang
Yang Bai
Hao Zha
Fangjie Jiang
Yushi Meng
Publication date
01-05-2020
Publisher
Springer US
Published in
Journal of Assisted Reproduction and Genetics / Issue 5/2020
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI
https://doi.org/10.1007/s10815-020-01737-2

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