Skip to main content
Top
Published in: Journal of Assisted Reproduction and Genetics 5/2020

01-05-2020 | Fertility | Fertility Preservation

Oocyte cryopreservation in two women with borderline ovarian tumor recurrence.

Authors: Francesca Filippi, Fabio Martinelli, Edgardo Somigliana, Dorella Franchi, Francesco Raspagliesi, Valentina Chiappa

Published in: Journal of Assisted Reproduction and Genetics | Issue 5/2020

Login to get access

Abstract

Borderline ovarian tumors (BOTs) commonly occur during reproductive years. Given the good prognosis, fertility-sparing surgery can be considered in young women wishing to preserve their fertility. However, conservative management exposes patients to the risk of recurrence. In these cases, the new surgery may be radical (completing the removal of both adnexa) or, when conservative, it may be associated with relevant damage to the ovarian reserve. In this study, we report on two women who decided to perform ovarian hyper-stimulation and oocyte cryostorage at the time of the diagnosis of recurrence, but before undergoing the new surgery. They both obtained a satisfactory number of oocytes, the retrieval was unremarkable, and no main detrimental effects on the ovarian lesions were noticed. These two cases suggest that ovarian hyper-stimulation and oocyte retrieval before planned surgery for BOT recurrence is a feasible option.
Literature
1.
go back to reference Harter P, Gershenson D, Lhomme C, Lecuru F, Ledermann J, Provencher DM, et al. Gynecologic Cancer InterGroup (GCIG) consensus review for ovarian tumors of low malignant potential (borderline ovarian tumors). Int J Gynecol Cancer. 2014;24(9 Suppl 3):S5–8.CrossRef Harter P, Gershenson D, Lhomme C, Lecuru F, Ledermann J, Provencher DM, et al. Gynecologic Cancer InterGroup (GCIG) consensus review for ovarian tumors of low malignant potential (borderline ovarian tumors). Int J Gynecol Cancer. 2014;24(9 Suppl 3):S5–8.CrossRef
2.
go back to reference du Bois A, Ewald-Riegler N, de Gregorio N, Reuss A, Mahner S, Fotopoulou C, et al. Borderline tumours of the ovary: A cohort study of the Arbeitsgmeinschaft Gynäkologische Onkologie (AGO) Study Group. Eur J Cancer. 2013;49:1905–14.CrossRef du Bois A, Ewald-Riegler N, de Gregorio N, Reuss A, Mahner S, Fotopoulou C, et al. Borderline tumours of the ovary: A cohort study of the Arbeitsgmeinschaft Gynäkologische Onkologie (AGO) Study Group. Eur J Cancer. 2013;49:1905–14.CrossRef
3.
go back to reference Mangili G, Somigliana E, Giorgione V, Martinelli F, Filippi F, Petrella MC, et al. Fertility preservation in women with borderline ovarian tumours. Cancer Treat Rev. 2016;49:13–24.CrossRef Mangili G, Somigliana E, Giorgione V, Martinelli F, Filippi F, Petrella MC, et al. Fertility preservation in women with borderline ovarian tumours. Cancer Treat Rev. 2016;49:13–24.CrossRef
4.
go back to reference Tinelli R, Tinelli A, Tinelli FG, Cicinelli E, Malvasi A. Conservative surgery for borderline ovarian tumors: a review. Gynecol Oncol. 2006;100:185–91.CrossRef Tinelli R, Tinelli A, Tinelli FG, Cicinelli E, Malvasi A. Conservative surgery for borderline ovarian tumors: a review. Gynecol Oncol. 2006;100:185–91.CrossRef
5.
go back to reference Daraï E, Fauvet R, Uzan C, Gouy S, Duvillard P, Morice P. Fertility and borderline ovarian tumor: a systematic review of conservative management, risk of recurrence and alternative options. Hum Reprod Update. 2013;19:151–66.CrossRef Daraï E, Fauvet R, Uzan C, Gouy S, Duvillard P, Morice P. Fertility and borderline ovarian tumor: a systematic review of conservative management, risk of recurrence and alternative options. Hum Reprod Update. 2013;19:151–66.CrossRef
6.
go back to reference Franchi D, Boveri S, Fruscio R, Fischerova D, Guerriero S, Moruzzi MC, et al. Imaging in gynecological disease (8): ultrasound characteristics of recurrent borderline ovarian tumors. Ultrasound Obstet Gynecol. 2013;41:452–8.CrossRef Franchi D, Boveri S, Fruscio R, Fischerova D, Guerriero S, Moruzzi MC, et al. Imaging in gynecological disease (8): ultrasound characteristics of recurrent borderline ovarian tumors. Ultrasound Obstet Gynecol. 2013;41:452–8.CrossRef
7.
go back to reference Filippi F, Martinelli F, Paffoni A, Reschini M, Raspagliesi F, Somigliana E. Fertility preservation in women with malignancies: the accuracy of antral follicle count collected randomly during the menstrual cycle in predicting the number of oocytes retrieved. J Assist Reprod Genet. 2019;36:569–78.CrossRef Filippi F, Martinelli F, Paffoni A, Reschini M, Raspagliesi F, Somigliana E. Fertility preservation in women with malignancies: the accuracy of antral follicle count collected randomly during the menstrual cycle in predicting the number of oocytes retrieved. J Assist Reprod Genet. 2019;36:569–78.CrossRef
8.
go back to reference Goldman RH, Racowsky C, Farland LV, Munné S, Ribustello L, Fox JH. Predicting the likelihood of live birth for elective oocyte cryopreservation: a counseling tool for physicians and patients. Hum Reprod. 2017;32:853–9.CrossRef Goldman RH, Racowsky C, Farland LV, Munné S, Ribustello L, Fox JH. Predicting the likelihood of live birth for elective oocyte cryopreservation: a counseling tool for physicians and patients. Hum Reprod. 2017;32:853–9.CrossRef
9.
go back to reference Franchi D, Boveri S, Radice D, Portuesi R, Zanagnolo V, Colombo N, et al. Ultrasonographic diagnosis and longitudinal follow-up of recurrences after conservative surgery for borderline ovarian tumors. Am J Obstet Gynecol. 2016;215(756):e1–9. Franchi D, Boveri S, Radice D, Portuesi R, Zanagnolo V, Colombo N, et al. Ultrasonographic diagnosis and longitudinal follow-up of recurrences after conservative surgery for borderline ovarian tumors. Am J Obstet Gynecol. 2016;215(756):e1–9.
10.
go back to reference Ortega I, García-Velasco JA, Pellicer A. Ovarian manipulation in ART: going beyond physiological standards to provide best clinical outcomes. J Assist Reprod Genet. 2018;35(10):1751–62.CrossRef Ortega I, García-Velasco JA, Pellicer A. Ovarian manipulation in ART: going beyond physiological standards to provide best clinical outcomes. J Assist Reprod Genet. 2018;35(10):1751–62.CrossRef
11.
go back to reference ESHRE Working group on ultrasound in ART, D′Angelo A, Panayotidis C, Amso N, Marci R, Matorras R, et al. Recommendations for good practice in ultrasound: oocyte pick up. Hum Reprod Open. 2019;4:hoz025.CrossRef ESHRE Working group on ultrasound in ART, D′Angelo A, Panayotidis C, Amso N, Marci R, Matorras R, et al. Recommendations for good practice in ultrasound: oocyte pick up. Hum Reprod Open. 2019;4:hoz025.CrossRef
12.
go back to reference Ben-Rafael Z. The dilemma of social oocyte freezing: usage rate is too low to make it cost-effective. Reprod BioMed Online. 2018;37(4):443–8.CrossRef Ben-Rafael Z. The dilemma of social oocyte freezing: usage rate is too low to make it cost-effective. Reprod BioMed Online. 2018;37(4):443–8.CrossRef
13.
go back to reference Mohamed AA, Al-Hussaini TK, Fathalla MM, El Shamy TT, Abdelaal II, Amer SA. The impact of excision of benign nonendometriotic ovarian cysts on ovarian reserve: a systematic review. Am J Obstet Gynecol. 2016;215:169–76.CrossRef Mohamed AA, Al-Hussaini TK, Fathalla MM, El Shamy TT, Abdelaal II, Amer SA. The impact of excision of benign nonendometriotic ovarian cysts on ovarian reserve: a systematic review. Am J Obstet Gynecol. 2016;215:169–76.CrossRef
Metadata
Title
Oocyte cryopreservation in two women with borderline ovarian tumor recurrence.
Authors
Francesca Filippi
Fabio Martinelli
Edgardo Somigliana
Dorella Franchi
Francesco Raspagliesi
Valentina Chiappa
Publication date
01-05-2020
Publisher
Springer US
Published in
Journal of Assisted Reproduction and Genetics / Issue 5/2020
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI
https://doi.org/10.1007/s10815-020-01733-6

Other articles of this Issue 5/2020

Journal of Assisted Reproduction and Genetics 5/2020 Go to the issue