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Published in: Journal of Assisted Reproduction and Genetics 5/2018

01-05-2018 | Review

Influence of follicular fluid and cumulus cells on oocyte quality: clinical implications

Authors: M. G. Da Broi, V. S. I. Giorgi, F. Wang, D. L. Keefe, D. Albertini, P. A. Navarro

Published in: Journal of Assisted Reproduction and Genetics | Issue 5/2018

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Abstract

An equilibrium needs to be established by the cellular and acellular components of the ovarian follicle if developmental competence is to be acquired by the oocyte. Both cumulus cells (CCs) and follicular fluid (FF) are critical determinants for oocyte quality. Understanding how CCs and FF influence oocyte quality in the presence of deleterious systemic or pelvic conditions may impact clinical decisions in the course of managing infertility. Given that the functional integrities of FF and CCs are susceptible to concurrent pathological conditions, it is important to understand how pathophysiological factors influence natural fertility and the outcomes of pregnancy arising from the use of assisted reproduction technologies (ARTs). Accordingly, this review discusses the roles of CCs and FF in ensuring oocyte competence and present new insights on pathological conditions that may interfere with oocyte quality by altering the intrafollicular environment.
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Metadata
Title
Influence of follicular fluid and cumulus cells on oocyte quality: clinical implications
Authors
M. G. Da Broi
V. S. I. Giorgi
F. Wang
D. L. Keefe
D. Albertini
P. A. Navarro
Publication date
01-05-2018
Publisher
Springer US
Published in
Journal of Assisted Reproduction and Genetics / Issue 5/2018
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI
https://doi.org/10.1007/s10815-018-1143-3

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