No malignancy detected in surplus ovarian tissue from a former Ewing sarcoma patient who experienced relapse four years after being grafted with frozen/thawed ovarian tissue

Excerpt

We have recently published a case report describing the first case of grafting frozen/thawed ovarian tissue for puberty induction to a young girl who had recovered from a malignant disease [1]. She had one of her ovaries frozen at 9 years of age prior to undergoing treatment for Ewing sarcoma, which included pre— and post operative chemotherapy comprising (total accumulated dose per m2), vincristine (21 mg), ifosfamide (60 g), doxorubicin (360 mg), etoposide (2.7 mg), actinomycin (9 mg), and cyclophosphamide (10.5 g) according to the EURO EWING-99 protocol. Subsequently, she underwent gross total surgical resection. Histological examination confirmed resection into healthy tissue. Postoperatively, a total irradiation dose of 41.2 Gy to the tumor bed during 23 treatments was given. When she was 13 years and had no ovarian activity, two of ten pieces of ovarian cortex were grafted to the remaining postmenopausal ovary. The grafted tissue regained activity and stimulated her pubertal development. …