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Journal of Assisted Reproduction and Genetics

Published in:

01-11-2014 | Assisted Reproduction Technologies

Deliveries of babies with normal health derived from oocytes with smooth endoplasmic reticulum clusters

Authors: Hiromitsu Hattori, Yusuke Nakamura, Yukiko Nakajo, Yasuhisa Araki, Koichi Kyono

Published in: Journal of Assisted Reproduction and Genetics | Issue 11/2014

Abstract

Purpose

To examine the impact on development of derived embryos from smooth endoplasmic reticulum clusters (SERC) in human metaphase II (MII) oocytes.

Methods

Retrospective analysis at Kyono ART Clinic. Comparison of embryological development, pregnancy, live birth and fetal malformation between oocytes with SERC (the SERC(+) group) and those without (the SERC(−) group) in 2,158 patients (3,758 cycles) after ICSI.

Results

Fertilization and implantation rate were significantly lower in SERC(+) MII oocytes than in SERC(−) MII oocytes. After the transfer of fresh and vitrified embryos derived from SERC(+) oocytes, 14 pregnancies resulted in 14 healthy babies, including 2 from fresh embryo transfer (ET) and 12 from vitrified-warmed ET, with no malformations.

Conclusion(s)

The presence of SERC in MII oocytes was associated with significantly lower fertilization rates and implantation rates than seen in SERC(−) MII oocytes within SERC (+) cycles. However, SERC had no impact on post-implantation development as well as neonatal outcome.

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Title: Deliveries of babies with normal health derived from oocytes with smooth endoplasmic reticulum clusters
Authors: Hiromitsu Hattori
Yusuke Nakamura
Yukiko Nakajo
Yasuhisa Araki
Koichi Kyono
Publication date: 01-11-2014
Publisher: Springer US
Published in: Journal of Assisted Reproduction and Genetics / Issue 11/2014
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-014-0323-z

At a glance: The STEP trials

Springer Medicine

Deliveries of babies with normal health derived from oocytes with smooth endoplasmic reticulum clusters

Abstract

Purpose

Methods

Results

Conclusion(s)

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion(s)

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