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International Ophthalmology

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01-06-2020 | Glaucoma | Original Paper

The impact of intraocular pressure fluctuations and other factors on conversion of ocular hypertension to primary open-angle glaucoma

Authors: Susanne Hopf, Doris Schwantuschke, Norbert Pfeiffer, Jochem Koenig, Katharina Bell, Esther Maria Hoffmann

Published in: International Ophthalmology | Issue 6/2020

Abstract

Purpose

To evaluate the role of intraocular pressure (IOP) fluctuations and other factors on conversion of ocular hypertension to open-angle glaucoma (OAG) within a retrospective, longitudinal cohort study.

Patients and methods

The study population included patients with ocular hypertension defined by IOP > 21 mmHg with normal appearing optic discs and no visual field defect. IOP fluctuation, mean and maximum were examined in 61 eyes over a follow-up period of 36 months (standard deviation (SD) 24). All patients underwent at least two 48-h IOP profiles including night-time IOP measurements in the supine position, visual field examinations, Heidelberg retina tomograph analyses (HRT) and optic disc photographs. Regression analyses were performed to demonstrate the impact of IOP parameters, myopia, sex, cup/disc ratio and visual field results on conversion to glaucoma.

Results

While IOP fluctuation and mean did not impact conversion, myopia proved to be a risk factor (HR 14.4; 95% CI: [3.9–53.0]; p ≤ 0.001). Over an average of three years, 6/61 converted to OAG. The study yielded a mean long-term IOP over all available pressure profiles of 18.1 mmHg (SD 3.2) and an IOP fluctuation of 1.9 mmHg (SD 1.1) within a mostly treated cohort. Conversion-free five-year rate was 59.8%.

Conclusions

The amount of fluctuation we measured in our study sample did not result in the development of glaucoma in treated ocular hypertension patients. Myopic subjects with ocular hypertension are at a higher risk for glaucoma conversion than non-myopic ocular hypertensive subjects are.

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Title: The impact of intraocular pressure fluctuations and other factors on conversion of ocular hypertension to primary open-angle glaucoma
Authors: Susanne Hopf
Doris Schwantuschke
Norbert Pfeiffer
Jochem Koenig
Katharina Bell
Esther Maria Hoffmann
Publication date: 01-06-2020
Publisher: Springer Netherlands
Keywords: Glaucoma
Hypertension
Hypertension
Published in: International Ophthalmology / Issue 6/2020
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI: https://doi.org/10.1007/s10792-020-01306-7

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

The impact of intraocular pressure fluctuations and other factors on conversion of ocular hypertension to primary open-angle glaucoma

Abstract

Purpose

Patients and methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Patients and methods

Results

Conclusions

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