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International Ophthalmology

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01-05-2020 | Angiography | Original Paper

Assessment of peripapillary vessel density in acute non-arteritic anterior ischemic optic neuropathy

Authors: Haitham Y. Al-Nashar, Sahar Hemeda

Published in: International Ophthalmology | Issue 5/2020

Abstract

Purpose

To assess the peripapillary perfusion in eyes with acute non-arteritic anterior ischemic optic neuropathy (NAION) using optical coherence tomography angiography (OCTA).

Methods

Twenty-five patients with unilateral acute NAION were included in this observational cross-sectional study. They were divided into two groups: group I (25 eyes) included eyes with acute NAION, and group II (25 eyes) included fellow normal eyes. Diagnosis of NAION was based on clinical examination and fluorescein angiography. OCTA (AngioVue, Optovue) was used to evaluate the optic nerve head perfusion and measure the peripapillary vessel density in all eyes included in the study.

Results

Fourteen male and 11 female patients with a mean age of 60.2 ± 3.5 years were included in this study. The mean duration of presentation was 4.3 ± 0.6 days. Mean BCVA was 0.13 ± 0.06 and 0.69 ± 0.18 in eyes with NAION and normal eyes, respectively (p < 0.001). The peripapillary vessel was significantly decreased in all eyes with NAION compared with normal ones (p < 0.001). Two morphological changes were noted in eyes with NAION: vascular dropout related to area of disc edema in 25 eyes (100% of eyes) and vascular dilatation with tortuosity in 17 eyes (68%).

Conclusion

Eyes with NAION have decreased peripapillary vessel density with peripapillary vascular dilatation and tortuosity as assessed by OCTA.

Jung JJ, Baek S, Kim US (2011) Analysis of the causes of optic disc swelling. Korean J Ophthalmol 1:33–36. https://doi.org/10.3341/kjo.2011.25.1.33 CrossRef

Smith CH (2005) Optic neuritis. In: Miller NR, Newman NJ, Biousse V (eds) Clinical neuro-ophthalmology, vol 1, 6th edn. Lippincott Williams & Wilkins, Philadelphia, pp 293–347

Hayreh SS (2009) Ischemic optic neuropathy. Prog Retin Eye Res 28:34–62. https://doi.org/10.1016/j.preteyeres.2008.11.002 CrossRefPubMed

Miller NR, Arnold AC (2015) Current concepts in the diagnosis, pathogenesis and management of nonarteritic anterior ischaemic optic neuropathy. Eye (Lond) 29:65–79. https://doi.org/10.1038/eye.2014.144 CrossRef

Hata M, Oishi A, Muraoka Y, Miyamoto K, Kawai K, Yokota S, Fujimoto M, Miyata M, Yoshimura N (2017) Structural and functional analyses in nonarteritic anterior ischemic optic neuropathy: optical coherence tomography angiography study. J Neuroophthalmol 37:140–148. https://doi.org/10.1097/WNO.0000000000000470 CrossRefPubMed

Liu CH, Wu WC, Sun MH, Kao LY, Lee YS, Chen HS (2017) Comparison of the retinal microvascular density between open angle glaucoma and nonarteritic anterior ischemic optic neuropathy. Invest Ophthalmol Vis Sci 58:3350–3356. https://doi.org/10.1167/iovs.17-22021 CrossRefPubMed

Kim MK, Kim US (2016) Analysis of Fundus Photography and Fluorescein Angiography in Nonarteritic Anterior Ischemic Optic Neuropathy and Optic Neuritis. Korean J Ophthalmol 30:289–94. https://doi.org/10.3341/kjo.2016.30.4.289 CrossRefPubMedPubMedCentral

Oto S, Yilmaz G, Cakmakci S, Aydin P (2002) Indocyanine green and fluorescein angiography in nonarteritic anterior ischemic optic neuropathy. Retina 22:187–91. https://doi.org/10.1097/00006982-200204000-00009 CrossRefPubMed

Liu CH, Kao LY, Sun MH, Wu WC, Chen HS (2017) Retinal vessel density in optical coherence tomography angiography in optic atrophy after nonarteritic anterior ischemic optic neuropathy. J Ophthalmol 2017:9632647. https://doi.org/10.1155/2017/9632647 CrossRefPubMedPubMedCentral

10.

Falavarjani GK, Tian JJ, Akil H, Garcia GA, Sadda SR, Sadun AA (2016) Swept source optical coherence tomography angiography of the optic disk in optic neuropathy. Retina 36:168–177. https://doi.org/10.1097/IAE.0000000000001259 CrossRef

11.

Rebolleda G, Diez-Alvarez L, Casado A, Sanchez- Sanchez C, de Dompablo E, Gonzalez-Lopez JJ, Munoz-Negrete FJ (2015) OCT: new perspectives in neuro-ophthalmology. Saudi J Ophthalmol 29:9–25. https://doi.org/10.1016/j.sjopt.2014.09.016 CrossRefPubMed

12.

Chen JJ, AbouChehade JE, Iezzi R Jr, Leavitt JA, Kardon RH (2017) Optical coherence angiographic demonstration of retinal changes from chronic optic neuropathies. Neuro-Ophthalmology 41:76–83. https://doi.org/10.1080/01658107.2016.1275703 CrossRefPubMedPubMedCentral

13.

De Dompablo E, Garcia-Montesinos J, Munoz-Negrete FJ, Rebolleda G (2016) Ganglion cell analysis at acute episode of nonarteritic anterior ischemic optic neuropathy to predict irreversible damage. A prospective study. Graefes Arch Clin Exp Ophthalmol 254:1793–1800. https://doi.org/10.1007/s00417-016-3425-8 CrossRefPubMed

14.

Hunder GG, Bloch DA, Michel BA, Stevens MB, Arend WP, Calabrese LH et al (1990) The American College of Rheumatology criteria for the classification of giant cell arteritis. Arthritis Rheum 33:1122–1128. https://doi.org/10.1002/art.1780330810 CrossRefPubMed

15.

Hayreh SS, Podhajsky PA, Raman R, Zimmerman B (1997) Giant cell arteritis: validity and reliability of various diagnostic criteria. Am J Ophthalmol 123:285–296. https://doi.org/10.1016/s0002-9394(14)70123-0 CrossRefPubMed

16.

Biousse V, Newman NJ (2015) Ischemic optic neuropathies. N Engl J Med 372:2428–2436. https://doi.org/10.1056/NEJMra1413352 CrossRefPubMed

17.

Knox DL, Kerrison JB, Green WR (2000) Histopathologic studies of ischemic optic neuropathy. Trans Am Ophthalmol Soc 98:203–220PubMedPubMedCentral

18.

Newman NJ, Scherer R, Langenberg P, Kelman S, Feldon S, Kaufman D et al (2002) The fellow eye in NAION: report from the ischemic optic neuropathy decompression trial follow-up study. Am J Ophthalmol 134:317–328CrossRef

19.

Palombi K, Renard E, Levy P, Chiquet C, Deschaux Ch, Romanet JP et al (2006) Non-arteritic anterior ischaemic optic neuropathy is nearly systematically associated with obstructive sleep apnea. Br J Opthalmol 90:879–82. https://doi.org/10.1136/bjo.2005.087452 CrossRef

20.

Ho SF, Dhar-Munshi S (2008) Nonarteritic anterior ischemic optic neuropathy. Curr Opin Ophthalmol 19:461–467. https://doi.org/10.1097/ICU.0b013e3283112bc8 CrossRefPubMed

21.

Girkin CA (2018) Is Nonarteritic Ischemic Optic Neuropathy Due to Choroidal Compression of the Prelaminar Neurovascular Compartment of the Optic Nerve Head? J Neuro ophthalmol 38:1–3. https://doi.org/10.1097/WNO.0000000000000628 CrossRef

22.

Gandhi U, Chhablani U, Badakere A, Kekunnaya R, Abdul Rasheed M, Goud A, Chhablani PP (2018) Optical coherence tomography angiography in acute unilateral nonarteritic anterior ischemic optic neuropathy: a comparison with the fellow eye and with eyes with papilledema. Indian J Ophthalmol 66:1144–1148. https://doi.org/10.4103/ijo.IJO-179-18 CrossRefPubMedPubMedCentral

23.

Rougier MB, Le Goff M, Korobelnik JF (2018) Optical coherence tomography angiography at the acute phase of optic disc edema. Eye Vis (Lond) 5:15–22. https://doi.org/10.1186/s40662-018-0109-y CrossRef

24.

Rebolleda G, Díez-Álvarez L, García Marín Y, de Juan V, Muñoz-Negrete FJ (2018) Optical coherence tomography angiography from the acute to the atrophic stage in non-arteritic anterior ischaemic optic neuropathy. Ophthalmologica 240:191–199. https://doi.org/10.1159/000489226 CrossRefPubMed

25.

Ling JW, Yin X, Lu QY, Chen YY, Lu PR (2017) Optical coherence tomography angiography of optic disc perfusion in non-arteritic anterior ischemic optic neuropathy. Int J Ophthalmol 10:1402–1406. https://doi.org/10.18240/ijo.2017.09.12

26.

Song Y, Min JY, Mao L, Gong YY (2018) Microvasculature dropout detected by the optical coherence tomography angiography in nonarteritic anterior ischemic optic neuropathy. Lasers Surg Med 50:194–201. https://doi.org/10.1002/lsm.22712 CrossRefPubMed

Title: Assessment of peripapillary vessel density in acute non-arteritic anterior ischemic optic neuropathy
Authors: Haitham Y. Al-Nashar
Sahar Hemeda
Publication date: 01-05-2020
Publisher: Springer Netherlands
Keywords: Angiography
Edema
Published in: International Ophthalmology / Issue 5/2020
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI: https://doi.org/10.1007/s10792-020-01293-9

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Assessment of peripapillary vessel density in acute non-arteritic anterior ischemic optic neuropathy

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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