Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
International Ophthalmology
Published in: International Ophthalmology 2/2018

01-04-2018 | Original Paper

Contribution of dual fluorescein and indocyanine green angiography to the appraisal of posterior involvement in birdshot retinochoroiditis and Vogt–Koyanagi–Harada disease

Authors: Ozlem Balci, Bruno Jeannin, Carl P. Herbort Jr.

Published in: International Ophthalmology | Issue 2/2018

Login to get access

Abstract

Purpose

To assess the levels of retinal and choroidal involvement in initial-onset birdshot retinochoroiditis (BRC) and Vogt–Koyanagi–Harada (VKH) disease, two stromal choroiditis entities.

Methods

This retrospective study included patients diagnosed with BRC and VKH, seen during initial-onset disease at the Centre for Ophthalmic Specialized Care, Lausanne, Switzerland. Angiographic signs were quantified, using an established dual fluorescein angiography (FA) and indocyanine green angiography (ICGA) scoring system for uveitis, and the FA/ICGA score ratios were compared between diseases.

Results

Among 1793 patients with uveitis seen from 1995 to 2015, 7 newly diagnosed BRC patients and 4 patients with newly diagnosed VKH disease had sufficient data for study inclusion. Patients with BRC and VKH at initial onset had mean FA angiographic scores of 16.91 ± 3.42 and 4.06 ± 1.87; mean ICGA angiographic scores of 21.34 ± 3.49 and 25.75 ± 3.88; and mean FA/ICGA ratios of 0.79 ± 0.21 and 0.16 ± 0.09, respectively.

Conclusion

This study showed the differential involvements of the retina and choroid in BRC and VKH. The choroid was preponderantly involved in both diseases; thus, ICGA is essential for disease assessment and follow-up. However, these diseases also differed substantially. The origin of inflammation was primarily in the choroid in VKH and in both the choroid and retina in BRC. We recommend dual FA and ICGA for evaluating posterior uveitis, when choroiditis is suspected.
Literature
1.
Brancato R, Trabucchi G (1998) Fluorescein and indocyanine green angiography in vascular chorioretinal diseases. Semin Ophthalmol 13:189–198CrossRefPubMed
2.
De Laey JJ (1996) Fluorescein angiography in posterior uveitis. Int Ophthalmol Clin 35:33–58CrossRef
3.
4.
Herbort CP, Guex-Crosier Y, Le Hoang P (1994) Schematic interpretation of indocyanine green angiography. Ophthalmology 2:169–176
5.
Herbort CP (1998) Posterior uveitis: new insights given by indocyanine green angiography. Eye 12:757–759CrossRefPubMed
6.
Herbort CP, Neri P, Abu El Asrar AA, Gupta V, Kestelyn P, Khairallah M, Mantovani A, Tugal-Tutkun I, Papadia M (2012) Is ICGA still relevant in inflammatory eye disorders? Why this question has to be dealt with separately from other eye conditions. Retina 32:1701–1703CrossRefPubMed
7.
Bouchenaki N, Cimino L, Auer C, Tran VT, Herbort CP (2002) Assessment and classification of choroidal vasculitis in posterior uveitis using indocyanine green angiography. Klin Monbl Augenheilkd 219:243–249CrossRefPubMed
8.
Cimino L, Auer C, Herbort CP (2000) Sensitivity of indocyanine green angiography for the follow-up of active inflammatory choriocapillaropathies. Ocul Immunol Inflamm 8:275–283CrossRefPubMed
9.
Bouchenaki N, Herbort CP (2004) Stromal choroiditis. In: Pleyer U, Mondino B (eds) Essentials in ophthalmology: uveitis and immunological disorders. Springer, Berlin, pp 234–253
10.
Fardeau C, Herbort CP, Kullman N, Quentel GG, LeHoang P (1999) Indocyanine green angiography in birdshot chorioretinopathy. Ophthalmology 106:1928–1934CrossRefPubMed
11.
Bouchenaki N, Herbort CP (2001) The contribution of indocyanine green angiography to the appraisal and management of Vogt–Koyanagi–Harada disease. Ophthalmology 108:54–64CrossRefPubMed
12.
Tugal-Tutkun I, Herbort CP, Khairallah M (2010) Angiography Scoring for Uveitis Working Group (ASUWOG). Scoring of dual fluorescein and ICG inflammatory angiographic signs for the grading of posterior segment inflammation (dual fluorescein and ICG angiographic scoring system for uveitis). Int Ophthalmol 30:539–552CrossRefPubMed
13.
Tugal-Tutkun I, Herbort CP, Khairallah M, Mantovani A (2010) Interobserver agreement in scoring of dual fluorescein and ICG inflammatory angiographic signs for the grading posterior segment inflammation. Ocul Immunol Inflamm 18:385–389CrossRefPubMed
14.
Papadia M, Herbort CP Jr (2015) New concepts in the appraisal and management of birdshot retinochoroiditis: a global perspective. Int Ophthalmol 35:287–301CrossRefPubMed
15.
Papadia M, Herbort CP (2013) Reappraisal of birdshot retinochoroiditis (BRC): a global approach. Graefe’s Arch Clin Exp Ophthalmol 251:861–869CrossRef
16.
Knecht PB, Papadia M, Herbort CP (2014) Early and sustained treatment modifies the phenotype of birdshot retinochoroiditis. Int Ophthalmol 34:563–574CrossRefPubMed
17.
Knecht PB, Papadia M, Herbort CP (2013) Granulomatous keratic precipitates in birdshot retinochoroiditis. Int Ophthalmol 33:133–137CrossRefPubMed
18.
Papadia M, Herbort CP (2012) Indocyanine green angiography (ICGA) is essential for the early diagnosis of birdshot chorioretinopathy. Klin Monbl Augenheilkd 229:348–352CrossRefPubMed
19.
Reddy AK, Gonzalez MA, Henry CR, Yeh S, Sobrin L, Albini TA (2015) Diagnostic sensitivity of indocyanine green angiography for birdshot chorioretinopathy. JAMA Ophthalmol 133:840–843CrossRefPubMed
20.
Herbort CP, Mantovani A, Bouchenaki N (2007) Indocyanine green angiography in Vogt–Koyanagi–Harada disease: angiographic signs and utility in patient follow-up. Int Ophthalmol 27:173–182CrossRefPubMed
21.
Miyanaga M, Kawaguchi T, Miyata K, Horie S, Mochizuki M, Herbort CP (2010) Indocyanine gree angiography findings in initial acute pre-treatment Vogt–Koyanagi–Harada disease in Japanese patients. Jpn J Ophthalmol 54:377–382CrossRefPubMed
22.
Balci O, Gasc A, Jeannin B, Herbort CP (2016) Enhanced depth imaging is less suited than indocyanine green angiography for close monitoring of primary stromal choroiditis: a pilot study. Int Ophthalmol. doi:10.​1007/​s10792-016-0303-7
23.
Abu El-Asrar A, Hemachandran S, Al-Mezaine HS, Kangave D, Al-Muammar AM (2012) The outcomes of mycophenolate mofetil therapy combined with systemic corticosteroids in acute uveitis associated with Vogt–Koyanagi–Harada disease. Acta Ophthalmol 90:603–608CrossRef
24.
Bouchenaki N, Herbort CP (2011) Indocyanine green angiography guided management of Vogt–Koyanagi–Harada disease. J Ophthalmic Vis Res 6:241–248PubMedPubMedCentral
25.
Kiss S, Ahmed M, Leiko E, Foster CS (2005) Long-term follow-up of patients with birdshot retinochoroidopathy treated with corticosteroid-sparing systemic immunomodulatory therapy. Ophthalmology 112:1066–1071CrossRefPubMed
26.
Cervantes-Castaneda RA, Gonzalez-Gonzalez LA, Cordero-Coma M et al (2013) Combined therapy of cyclosporine A and mycophenolate mofetil for the treatment of birdshot retinochoroidopathy: a 12-month follow-up. Br J Ophthalmol 97:637–643CrossRefPubMed
27.
de Courten C, Herbort CP (1998) Potential role of computerized visual field testing for the appraisal and follow-up of birdshot chorioretinopathy. Arch Ophthalmol 116:1389–1391PubMed
28.
Thorne JE, Jabs DA, Kedhar SR et al (2008) Loss of visual field among patients with birdshot chorioretinopathy. Am J Ophthalmol 145:23–28CrossRefPubMed
29.
Papadia M, Jeannin B, Herbort CP (2012) OCT findings in birdshot chorioretinitis: a glimpse into retinal disease evolution. Ophthalmic Surg Lasers Imaging 43:25–31CrossRef
30.
31.
Nakai K, Gomi F, Ikuno Y, Yasuno Y, Nouchi T, Ohguro N, Nishida K (2012) Choroidal observation in Vogt–Koyanagi–Harada disease using high-penetration optical coherence tomography. Graefe’s Arch Clin Exp Ophthalmol 250:1089–1095CrossRef
32.
Birnbaum AD, Fawzi AA, Rademaker A, Goldstein DA (2014) Correlation between clinical signs and optical coherence tomography with enhanced depth imaging findings in patients with birdshot retinochoroidopathy. JAMA Ophthalmol 132:929–935CrossRefPubMed
Metadata
Title
Contribution of dual fluorescein and indocyanine green angiography to the appraisal of posterior involvement in birdshot retinochoroiditis and Vogt–Koyanagi–Harada disease
Authors
Ozlem Balci
Bruno Jeannin
Carl P. Herbort Jr.
Publication date
01-04-2018
Publisher
Springer Netherlands
Published in
International Ophthalmology / Issue 2/2018
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI
https://doi.org/10.1007/s10792-017-0487-5

Other articles of this Issue 2/2018

International Ophthalmology 2/2018 Go to the issue

Original Paper

Choroidal thickness alterations in diabetic nephropathy patients with early or no diabetic retinopathy

Original Paper

Usability and reproducibility of tear meniscus values generated via swept-source optical coherence tomography and the slit lamp with a graticule method

Review

Heavy and standard silicone oil: intraocular inflammation

Original Paper

IOP measurement in silicone oil tamponade eyes by Corvis ST tonometer, Goldmann applanation tonometry and non-contact tonometry

Original Paper

Impact of dehydration and fasting on intraocular pressure and corneal biomechanics measured by the Ocular Response Analyzer

Case Report

Supradescemetic voriconazole injection for Candida parapsilosis keratitis