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International Ophthalmology

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01-04-2018 | Original Paper

Impact of dehydration and fasting on intraocular pressure and corneal biomechanics measured by the Ocular Response Analyzer

Authors: Betul Seher Uysal, Necati Duru, Umut Ozen, Mucella Arikan Yorgun, Emine Akcay, Mehtap Caglayan, Nurullah Cagil

Published in: International Ophthalmology | Issue 2/2018

Abstract

Purpose

To investigate the effects of dehydration and fasting on the intraocular pressure (IOP) and corneal biomechanics during Ramadan in healthy subjects.

Methods

A total of 36 healthy fasting male volunteers with a mean age of 32.7 ± 5.1 years (range 28–38 years) were enrolled in the study. A Reichert Ocular Response Analyzer (ORA) was used to measure the corneal resistance factor (CRF), corneal hysteresis (CH), Goldman-correlated IOP (IOPg), and corneal-compensated IOP (IOPcc), additionally IOP with Goldmann applanation tonometer (IOP-GAT) was taken. All measurements were recorded at 8:00 am and 4:00 p.m. during Ramadan and during a 1-month follow-up after Ramadan was over.

Results

Statistical analysis demonstrated no difference in the ORA measurements including CH, CRF, IOPcc, and IOPg; CCT and CV values between fasting and non-fasting periods or within a single day (diurnal changes). Nine volunteers (25% of total subjects) were excluded because eyedrops were believed to disrupt the Ramadan fast consequently IOP-GAT could not be measured from these subjects. No statistically significant difference was noted between IOP-GAT and IOPg measurements of twenty-seven subjects at the different periods and time points.

Conclusions

Our results reveal that fasting during Ramadan does not profoundly affect corneal biomechanics and IOP values in healthy volunteers without ocular diseases such as glaucoma. When planning corneal refractive surgery and determining IOP, the ORA measurements can be done safely during a Ramadan fast. Moreover, ORA may be a better alternative for patients that refuse IOP measurement via GAT for examining the accuracy of IOP during fasting. Further studies are needed to better understand the role of these parameters on corneal disease and glaucoma during fasting.

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Title: Impact of dehydration and fasting on intraocular pressure and corneal biomechanics measured by the Ocular Response Analyzer
Authors: Betul Seher Uysal
Necati Duru
Umut Ozen
Mucella Arikan Yorgun
Emine Akcay
Mehtap Caglayan
Nurullah Cagil
Publication date: 01-04-2018
Publisher: Springer Netherlands
Published in: International Ophthalmology / Issue 2/2018
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI: https://doi.org/10.1007/s10792-017-0479-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Impact of dehydration and fasting on intraocular pressure and corneal biomechanics measured by the Ocular Response Analyzer

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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