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Inflammation
Published in: Inflammation 5/2018

01-10-2018 | REVIEW

Mechanisms of Hemolysis During Sepsis

Authors: Katharina Effenberger-Neidnicht, Matthias Hartmann

Published in: Inflammation | Issue 5/2018

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Abstract

Cell-free hemoglobin is increasingly playing a more central role in the pathogenesis of sepsis being proved to be a potent predictor of patient’s outcome. It is crucial, hence, to further investigate the mechanisms of sepsis-induced hemolysis with the aim of deriving possible therapeutic principles. Herein, we collected the most important previously known triggers of hemolysis during sepsis, which are (1) transfusion reactions and complement activation, (2) disseminated intravascular coagulation, (3) capillary stopped-flow, (4) restriction of glucose to red blood cells, (5) changes in red blood cell membrane properties, (6) hemolytic pathogens, and (7) red blood cell apoptosis.
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Metadata
Title
Mechanisms of Hemolysis During Sepsis
Authors
Katharina Effenberger-Neidnicht
Matthias Hartmann
Publication date
01-10-2018
Publisher
Springer US
Published in
Inflammation / Issue 5/2018
Print ISSN: 0360-3997
Electronic ISSN: 1573-2576
DOI
https://doi.org/10.1007/s10753-018-0810-y

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