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Inflammation
Published in: Inflammation 3/2018

01-06-2018 | ORIGINAL ARTICLE

Burn-Induced Multiple Organ Injury and Protective Effect of Lutein in Rats

Authors: Huda O. AbuBakr, Samira H. Aljuaydi, Shimaa M. Abou-Zeid, Amanallah El-Bahrawy

Published in: Inflammation | Issue 3/2018

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Abstract

Thermal injury may lead to multiple organ dysfunction through release of proinflammatory mediators and reactive oxygen radicals. This study investigated the effects of thermal injury on remote organs of rats and the possible protective effect of lutein. Thermal trauma was induced in the back of rats by exposing them to 90 °C bath for 10 s. Rats were sacrificed 48 h after burn, and blood samples were collected to monitor liver and kidney functions. Tissue samples from liver, kidneys, and lungs were taken for studying oxidative stress parameters, gene expressions of TNF-α and Casp-3, besides histopathological examination. Skin scald injury caused significant elevations of liver and kidney function biomarkers in the serum. In tissue samples, increments of MDA, GPx, and 8-OHdG were recorded while GSH level and the activities of CAT and SOD were suppressed. The expressions of TNF-α and caspase-3 mRNA were increased, and histopathological results revealed remote organ injury. Oral administration of lutein (250 mg/kg) resulted in amelioration of the biochemical and molecular changes induced by burn as well as the histopathological alterations. According to the findings of the present study, lutein possesses anti-oxidant, anti-inflammatory, and anti-apoptotic effects that protect against burn-induced damage in remote organs.
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Metadata
Title
Burn-Induced Multiple Organ Injury and Protective Effect of Lutein in Rats
Authors
Huda O. AbuBakr
Samira H. Aljuaydi
Shimaa M. Abou-Zeid
Amanallah El-Bahrawy
Publication date
01-06-2018
Publisher
Springer US
Published in
Inflammation / Issue 3/2018
Print ISSN: 0360-3997
Electronic ISSN: 1573-2576
DOI
https://doi.org/10.1007/s10753-018-0730-x

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