Top

Published in:

01-02-2017 | REVIEW

Association of interleukin-18 and asthma

Authors: Ming-Hui Xu, Feng-Lai Yuan, Shu-Jing Wang, Hui-Ying Xu, Cheng-Wan Li, Xiao Tong

Published in: Inflammation | Issue 1/2017

Abstract

Cytokine-mediated immunity plays a dominant role in the pathogenesis of various immune diseases, including asthma. The recent identification of the family interleukin (IL)-1-related cytokine IL-18 now contributes to our understanding of the fine-tuning of cellular immunity. IL-18 can act as a cofactor for Th2 cell development and IgE production and also plays an important role in the differentiation of Th1 cells. Recent work identified an IL-18 association with the pathogenesis of asthma, wherein increased IL-18 expression was found in the serum of patients. Furthermore, IL-18 polymorphisms with susceptibility to asthma were reported, suggesting that IL-18 may be therapeutically relevant to asthma. In this review, we discuss the role of IL-18 in the pathogenesis of asthma and its therapeutic potential based on current research.

Bousquet, J., P.J. Bousquet, P. Godard, and J.P. Daures. 2005. The public health implications of asthma. Bulletin of the World Health Organization 83: 548–554.PubMedPubMedCentral

Deo, S.S., K.J. Mistry, A.M. Kakade, and P.V. Niphadkar. 2010. Role played by Th2 type cytokines in IgE mediated allergy and asthma. Lung India : Official Organ of Indian Chest Society 27: 66–71.CrossRef

Lund, S., H.H. Walford, and T.A. Doherty. 2013. Type 2 innate lymphoid cells in allergic disease. Current Immunology Reviews 9: 214–221.CrossRefPubMedPubMedCentral

Sims, J.E. 2002. IL-1 and IL-18 receptors, and their extended family. Current Opinion in Immunology 14: 117–122.CrossRefPubMed

Okamura, H., H. Tsutsi, T. Komatsu, M. Yutsudo, A. Hakura, T. Tanimoto, et al. 1995. Cloning of a new cytokine that induces IFN-gamma production by T cells. Nature 378: 88–91.CrossRefPubMed

Nakanishi, K., T. Yoshimoto, H. Tsutsui, and H. Okamura. 2001. Interleukin-18 regulates both Th1 and Th2 responses. Annual Review of Immunology 19: 423–474.CrossRefPubMed

Romagnani, S. 1999. Th1/Th2 cells. Inflammatory Bowel Diseases 5: 285–294.CrossRefPubMed

Wild, J.S., A. Sigounas, N. Sur, M.S. Siddiqui, R. Alam, M. Kurimoto, et al. 2000. IFN-gamma-inducing factor (IL-18) increases allergic sensitization, serum IgE, Th2 cytokines, and airway eosinophilia in a mouse model of allergic asthma. Journal of Immunology 164: 2701–2710.CrossRef

Rovina, N., E. Dima, P. Bakakos, E. Tseliou, K. Kontogianni, S. Papiris, et al. 2015. Low interleukin (IL)-18 levels in sputum supernatants of patients with severe refractory asthma. Respiratory Medicine 109: 580–587.CrossRefPubMed

10.

Imaoka, H., G.M. Gauvreau, R.M. Watson, S.G. Smith, B. Dua, A.J. Baatjes, et al. 2011. Interleukin-18 and interleukin-18 receptor-alpha expression in allergic asthma. The European Respiratory Journal 38: 981–983.CrossRefPubMed

11.

Imaoka, H., S. Takenaka, T. Kawayama, H. Oda, Y. Kaku, M. Matsuoka, et al. 2013. Increased serum levels of soluble IL-18 receptor complex in patients with allergic asthma. Allergology International: Official Journal of the Japanese Society of Allergology 62: 513–515.CrossRef

12.

Kawayama, T., M. Okamoto, H. Imaoka, S. Kato, H.A. Young, and T. Hoshino. 2012. Interleukin-18 in pulmonary inflammatory diseases. Journal of Interferon & Cytokine Research: the Official Journal of The International Society for Interferon and Cytokine Research 32: 443–449.CrossRef

13.

Lu, H., X. Yang, K. Takeda, D. Zhang, Y. Fan, M. Luo, et al. 2000. Chlamydia trachomatis mouse pneumonitis lung infection in IL-18 and IL-12 knockout mice: IL-12 is dominant over IL-18 for protective immunity. Molecular Medicine 6: 604–612.PubMedPubMedCentral

14.

Mihm, S., S. Schweyer, and G. Ramadori. 2003. Expression of the chemokine IP-10 correlates with the accumulation of hepatic IFN-gamma and IL-18 mRNA in chronic hepatitis C but not in hepatitis B. Journal of Medical Virology 70: 562–570.CrossRefPubMed

15.

Mallat, Z., A. Corbaz, A. Scoazec, S. Besnard, G. Leseche, Y. Chvatchko, et al. 2001. Expression of interleukin-18 in human atherosclerotic plaques and relation to plaque instability. Circulation 104: 1598–1603.CrossRefPubMed

16.

Guo, H., H. Deng, H. Cui, X. Peng, J. Fang, Z. Zuo, et al. 2015. Nickel chloride (NiCl2)-caused inflammatory responses via activation of NF-kappaB pathway and reduction of anti-inflammatory mediator expression in the kidney. Oncotarget 6: 28607–28620.PubMedPubMedCentral

17.

Debets, R., J.C. Timans, T. Churakowa, S. Zurawski, R. de Waal Malefyt, K.W. Moore, et al. 2000. IL-18 receptors, their role in ligand binding and function: anti-IL-1RAcPL antibody, a potent antagonist of IL-18. Journal of Immunology 165: 4950–4956.CrossRef

18.

Harada, M., K. Obara, T. Hirota, T. Yoshimoto, Y. Hitomi, M. Sakashita, et al. 2009. A functional polymorphism in IL-18 is associated with severity of bronchial asthma. American Journal of Respiratory and Critical Care Medicine 180: 1048–1055.CrossRefPubMed

19.

Yang D.X., Li N., Zhang X.L., Wang Q. 2012. [Serum interleukin 18 and 33 levels and its clinical significance in asthma patients]. Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 35:493–496.

20.

Zhang, J., L. Zheng, D. Zhu, H. An, Y. Yang, Y. Liang, et al. 2014. Polymorphisms in the interleukin 18 receptor 1 gene and tuberculosis susceptibility among Chinese. PloS One 9: e110734.CrossRefPubMedPubMedCentral

21.

Kuribayashi, K., T. Kodama, H. Okamura, M. Sugita, and T. Matsuyama. 2002. Effects of post-inhalation treatment with interleukin-12 on airway hyper-reactivity, eosinophilia and interleukin-18 receptor expression in a mouse model of asthma. Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology 32: 641–649.CrossRef

22.

Lunding, L., A. Schroder, and M. Wegmann. 2015. Allergic airway inflammation: unravelling the relationship between IL-37, IL-18Ralpha and Tir8/SIGIRR. Expert Review of Respiratory Medicine 9: 739–750.CrossRefPubMed

23.

Hossny, E.M., S.S. El-Sayed, E.S. El-Hadidi, and S.R. Moussa. 2009. Serum interleukin-18 expression in children with bronchial asthma. The World Allergy Organization Journal 2: 63–68.CrossRefPubMedPubMedCentral

24.

Kroeger, K.M., B.M. Sullivan, and R.M. Locksley. 2009. IL-18 and IL-33 elicit Th2 cytokines from basophils via a MyD88- and p38alpha-dependent pathway. Journal of Leukocyte Biology 86: 769–778.CrossRefPubMedPubMedCentral

25.

Oda H., Kawayama T., Imaoka H., Sakazaki Y., Kaku Y., Okamoto M., et al. 2014. Interleukin-18 expression, CD8(+) T cells, and eosinophils in lungs of nonsmokers with fatal asthma. Annals of allergy, asthma & immunology: official publication of the American College of Allergy, Asthma, & Immunology 112:23–28 e21.

26.

Sawada, M., T. Kawayama, H. Imaoka, Y. Sakazaki, H. Oda, S. Takenaka, et al. 2013. IL-18 induces airway hyperresponsiveness and pulmonary inflammation via CD4+ T cell and IL-13. PloS One 8: e54623.CrossRefPubMedPubMedCentral

27.

Murai, H., H. Qi, B. Choudhury, J. Wild, N. Dharajiya, S. Vaidya, et al. 2012. Alternaria-induced release of IL-18 from damaged airway epithelial cells: an NF-kappaB dependent mechanism of Th2 differentiation? PloS One 7: e30280.CrossRefPubMedPubMedCentral

Title: Association of interleukin-18 and asthma
Authors: Ming-Hui Xu
Feng-Lai Yuan
Shu-Jing Wang
Hui-Ying Xu
Cheng-Wan Li
Xiao Tong
Publication date: 01-02-2017
Publisher: Springer US
Published in: Inflammation / Issue 1/2017
Print ISSN: 0360-3997
Electronic ISSN: 1573-2576
DOI: https://doi.org/10.1007/s10753-016-0467-3

ACC 2024 Congress Coverage

Heart Failure Video

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Association of interleukin-18 and asthma

Abstract

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 1/2017

The Spatio-Temporal Expression Profiles of CD4 + T Cell Differentiation and Function-Related Genes During EAE Pathogenesis

Troxerutin Preconditioning and Ischemic Postconditioning Modulate Inflammatory Response after Myocardial Ischemia/Reperfusion Injury in Rat Model

Protective Effect of Crocodile Hemoglobin and Whole Blood Against Hydrogen Peroxide-Induced Oxidative Damage in Human Lung Fibroblasts (MRC-5) and Inflammation in Mice

Intranasal Curcumin Inhibits Pulmonary Fibrosis by Modulating Matrix Metalloproteinase-9 (MMP-9) in Ovalbumin-Induced Chronic Asthma

Distinct Secretory Activity and Clinical Impact of Subcutaneous Abdominal Adipose Tissue in Women with Rheumatoid Arthritis and Osteoarthritis

Polysaccharides from Arnebia euchroma Ameliorated Endotoxic Fever and Acute Lung Injury in Rats Through Inhibiting Complement System

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page