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Inflammation
Published in: Inflammation 6/2016

01-12-2016 | ORIGINAL ARTICLE

Therapeutic Effects of Resveratrol in a Mouse Model of LPS and Cigarette Smoke-Induced COPD

Authors: Jinlong Chen, Xu Yang, Weiya Zhang, Danhua Peng, Yanan Xia, Yi Lu, Xiaodong Han, Guangjie Song, Jing Zhu, Renping Liu

Published in: Inflammation | Issue 6/2016

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Abstract

This study was designed to examine whether resveratrol exerts the protective effects on LPS and cigarette smoke (LC)-induced COPD in a murine model. In lung histopathological studies, H&E, Masson’s trichrome, and AB-PAS staining were performed. The cytokines (IL-6, IL-17, TGF-β, and TNF-α) and inflammatory cells in BALF were determined. The Beclin1 level in the lungs of mouse was analyzed. Compared with the LC-induced mouse, the level of inflammatory cytokines (IL-17, IL-6, TNF-α, and TGF-β) of the BALF in the resveratrol + cigarette smoke-treated mouse had obviously decreased. Histological examination of the lung tissue revealed that the resveratrol treatment attenuated the fibrotic response and mucus hypersecretion. In addition, resveratrol inhibited the expression of the Beclin1 protein in mouse lungs. The presented findings collectively suggest that resveratrol has a therapeutic effect on mouse LC-induced COPD, and its mechanism of action might be related to reducing the production of the Beclin1 protein.
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Metadata
Title
Therapeutic Effects of Resveratrol in a Mouse Model of LPS and Cigarette Smoke-Induced COPD
Authors
Jinlong Chen
Xu Yang
Weiya Zhang
Danhua Peng
Yanan Xia
Yi Lu
Xiaodong Han
Guangjie Song
Jing Zhu
Renping Liu
Publication date
01-12-2016
Publisher
Springer US
Published in
Inflammation / Issue 6/2016
Print ISSN: 0360-3997
Electronic ISSN: 1573-2576
DOI
https://doi.org/10.1007/s10753-016-0430-3

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