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01-04-2016 | ORIGINAL ARTICLE

Anti-inflammatory Steroid from Phragmitis rhizoma Modulates LPS-Mediated Signaling Through Inhibition of NF-κB Pathway

Authors: Sook Jahr Park, Young Woo Kim, Moon Ki Park, Sung Hui Byun, Sang Chan Kim, Jong Rok Lee

Published in: Inflammation | Issue 2/2016

ABSTRACT

Lipopolysaccharides (LPS) strongly stimulate immune cells, and unabated activation of immune system by LPS may lead to an exacerbation of sickness and depression. In this study, stigmasta-3,5-dien-7-one (ST) was isolated from Phragmitis rhizoma as a negative regulator of LPS-induced inflammation in macrophages. ST effectively reduced nitric oxide (NO), prostaglandin E₂, and pro-inflammatory cytokine levels, which were markedly raised by LPS treatment. In addition, ST blocked the nuclear factor-kappa B (NF-κB) signaling pathway via down-regulation of phospho-p38 mitogen-activated protein kinase and phosphorylation and degradation of the inhibitor of NF-κB α. To our knowledge, this is the first study showing anti-inflammatory activities of ST isolated from Phragmitis rhizoma.

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Title: Anti-inflammatory Steroid from Phragmitis rhizoma Modulates LPS-Mediated Signaling Through Inhibition of NF-κB Pathway
Authors: Sook Jahr Park
Young Woo Kim
Moon Ki Park
Sung Hui Byun
Sang Chan Kim
Jong Rok Lee
Publication date: 01-04-2016
Publisher: Springer US
Published in: Inflammation / Issue 2/2016
Print ISSN: 0360-3997
Electronic ISSN: 1573-2576
DOI: https://doi.org/10.1007/s10753-015-0299-6

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