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Inflammation
Published in: Inflammation 1/2016

01-02-2016

Inhibition of Radiation-Induced Oxidative Damage in the Lung Tissue: May Acetylsalicylic Acid Have a Positive Role?

Authors: Can Demirel, Sevil Cagiran Kilciksiz, Serkan Gurgul, Nurten Erdal, Seyran Yigit, Lulufer Tamer, Lokman Ayaz

Published in: Inflammation | Issue 1/2016

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Abstract

The lung is relatively sensitive to irradiation. It is shown that acetylsalicylic acid (ASA) might reduce oxidative injury and that it has a place in protection from cancer. The aim of this study is to evaluate the potential radioprotective effects of ASA. Whole-body irradiation (6 Gy, single dose) was applied to the rats. Glutathione (GSH), malondialdehyde (MDA), myeloperoxidase (MPO), and nitric oxide (NO) levels in the lung tissue were measured. Control (C), Radiation (R), Radiation + ASA (R + ASA; received irradiation and 25 mg/kg of ASA intraperitoneally (i.p.)), and Radiation + Amifostine (R + WR-2721; received irradiation and 200 mg/kg of WR-2721 i.p.) groups were used. The MPO levels decreased statistically significantly in the group administered ASA. Histopathologically, a radioprotective effect of ASA was more evident in the R + ASA group. ASA is an agent which has not been used as a radioprotector in the clinic yet, and it is worth supporting with more advanced studies.
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Metadata
Title
Inhibition of Radiation-Induced Oxidative Damage in the Lung Tissue: May Acetylsalicylic Acid Have a Positive Role?
Authors
Can Demirel
Sevil Cagiran Kilciksiz
Serkan Gurgul
Nurten Erdal
Seyran Yigit
Lulufer Tamer
Lokman Ayaz
Publication date
01-02-2016
Publisher
Springer US
Published in
Inflammation / Issue 1/2016
Print ISSN: 0360-3997
Electronic ISSN: 1573-2576
DOI
https://doi.org/10.1007/s10753-015-0234-x

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