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Inflammation
Published in: Inflammation 5/2014

01-10-2014

Oxidative Stress and Inflammation Are Differentially Affected by Atorvastatin, Pravastatin, Rosuvastatin, and Simvastatin on Lungs from Mice Exposed to Cigarette Smoke

Authors: Thiago Santos Ferreira, Manuella Lanzetti, Marina Valente Barroso, Carlos Romualdo Rueff-Barroso, Cláudia Farias Benjamim, Lycia de Brito-Gitirana, Luís Cristóvão Porto, Samuel Santos Valença

Published in: Inflammation | Issue 5/2014

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Abstract

Our aim was to investigate the effects of four different statins on acute lung inflammation induced by cigarette smoke (CS). C57BL/6 male mice were divided into a control group (sham-smoked) and mice exposed to CS from 12 cigarettes/day for 5 days. Mice exposed to CS were grouped and treated with vehicle (i.p.), atorvastatin (10 mg/kg), pravastatin (10 mg/kg), rosuvastatin (5 mg/kg), or simvastatin (20 mg/kg). Treatment with statins differentially improved the pulmonary response when compared to the CS group. Atorvastatin and pravastatin demonstrated slightly effects on inflammation and oxidative stress. Rosuvastatin demonstrated the best anti-inflammatory effect, whereas simvastatin demonstrated the best antioxidant response.
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Metadata
Title
Oxidative Stress and Inflammation Are Differentially Affected by Atorvastatin, Pravastatin, Rosuvastatin, and Simvastatin on Lungs from Mice Exposed to Cigarette Smoke
Authors
Thiago Santos Ferreira
Manuella Lanzetti
Marina Valente Barroso
Carlos Romualdo Rueff-Barroso
Cláudia Farias Benjamim
Lycia de Brito-Gitirana
Luís Cristóvão Porto
Samuel Santos Valença
Publication date
01-10-2014
Publisher
Springer US
Published in
Inflammation / Issue 5/2014
Print ISSN: 0360-3997
Electronic ISSN: 1573-2576
DOI
https://doi.org/10.1007/s10753-014-9860-y

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