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Published in: Inflammation 5/2013

01-10-2013

Dioscorin Pre-treatment Protects A549 Human Airway Epithelial Cells from Hydrogen Peroxide-Induced Oxidative Stress

Authors: Jeng-Yuan Hsu, Jao-Jia Chu, Ming-Chih Chou, Ya-Wen Chen

Published in: Inflammation | Issue 5/2013

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Abstract

Hydrogen peroxide (H2O2) is a highly reactive oxygen species involved in lung and bronchial epithelium injury. Increased H2O2 levels have been reported in expired breath condensates of patients with inflammatory airway diseases such as chronic obstructive pulmonary disease. Protecting airway epithelial cells from oxidative stress is an important task in the prevention and management of airway diseases. Previous studies demonstrate that yam (Dioscorea batatas Decne) has antioxidant and anti-trypsin activities. This study evaluated the validity of dioscorin in vitro. The results showed that dioscorin attenuated the alteration of H2O2 on G2/M cell cycle arrest. This might be associated with the activation of IκB and subsequent inactivation of NF-κB. Furthermore, dioscorin suppressed IL-8 secretion and reduced changes of adhesion molecule expressions in H2O2-injured A549 cells. These results help in understanding the potential of traditional Chinese herbal medicine as treatment for airway inflammatory diseases.
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Metadata
Title
Dioscorin Pre-treatment Protects A549 Human Airway Epithelial Cells from Hydrogen Peroxide-Induced Oxidative Stress
Authors
Jeng-Yuan Hsu
Jao-Jia Chu
Ming-Chih Chou
Ya-Wen Chen
Publication date
01-10-2013
Publisher
Springer US
Published in
Inflammation / Issue 5/2013
Print ISSN: 0360-3997
Electronic ISSN: 1573-2576
DOI
https://doi.org/10.1007/s10753-013-9633-z

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