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Published in:

01-04-2013

Retinol Suppresses the Activation of Toll-Like Receptors in MyD88- and STAT1-Independent Manners

Authors: So Young Kim, Jung Eun Koo, Mi-Ryoung Song, Joo Young Lee

Published in: Inflammation | Issue 2/2013

Abstract

Dysregulation of Toll-like receptor (TLR) activation is well known to be linked to development and aggravation of inflammatory diseases and immune disorders. Retinol is reported to participate in regulation of immune responses. However, it has not been fully understood how retinol regulates TLR activation in macrophages. Our results showed that retinol suppressed the expression of various inflammatory cytokines in bone marrow-derived macrophages stimulated with ligands of TLR2, TLR3, or TLR4. These demonstrate that inhibitory effect of retinol is not limited to a single TLR. Inhibitory effect of retinol on lipopolysaccharide-induced target gene expression was still observed in myeloid differentiation primary-response protein 88 (MyD88)- or signal transducer and activator of transcription 1 (STAT1)-deficient macrophages, indicating that MyD88 and STAT1 are dispensable for retinol-mediated blockade of TLRs. Together, the results demonstrate that retinol suppresses the activation of TLRs in macrophages resulting in downregulation of inflammatory gene expression and further suggest that beneficial effect of retinol is mediated through regulation of TLR-mediated inflammatory responses.

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Title: Retinol Suppresses the Activation of Toll-Like Receptors in MyD88- and STAT1-Independent Manners
Authors: So Young Kim
Jung Eun Koo
Mi-Ryoung Song
Joo Young Lee
Publication date: 01-04-2013
Publisher: Springer US
Published in: Inflammation / Issue 2/2013
Print ISSN: 0360-3997
Electronic ISSN: 1573-2576
DOI: https://doi.org/10.1007/s10753-012-9562-2

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