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Inflammation
Published in: Inflammation 1/2012

01-02-2012

Inhibitory Effects of Prior Low-dose X-irradiation on Cold-induced Brain Injury in Mouse

Authors: Masaaki Yoshimoto, Takahiro Kataoka, Teruaki Toyota, Takehito Taguchi, Kiyonori Yamaoka

Published in: Inflammation | Issue 1/2012

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Abstract

We examined the inhibitory effects of low-dose X-irradiation on mouse brain tissue with cold-induced injury by comparing tissue samples from three groups of mice: control, sham-irradiated cold-exposed, and X-ray-irradiated (0.5 Gy) cold-exposed mice. The water content in brain increased significantly in the sham-irradiated group following the cold-induced injury relative to the control group. However, water content in brain tissue from the X-ray-irradiated group was significantly lower than that from the sham-irradiated group. Levels of antioxidants, such as superoxide dismutase and glutathione, in brain tissue from the X-ray-irradiated group were higher than those from the sham-irradiated group. Moreover, the cold injury-induced cell death, particularly apoptosis, while low-dose irradiation inhibited cell death, especially among glial cells, but not numeral cells. These findings suggest that prior low-dose X-irradiation activated antioxidant function and inhibited cold-induced brain injury.
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Metadata
Title
Inhibitory Effects of Prior Low-dose X-irradiation on Cold-induced Brain Injury in Mouse
Authors
Masaaki Yoshimoto
Takahiro Kataoka
Teruaki Toyota
Takehito Taguchi
Kiyonori Yamaoka
Publication date
01-02-2012
Publisher
Springer US
Published in
Inflammation / Issue 1/2012
Print ISSN: 0360-3997
Electronic ISSN: 1573-2576
DOI
https://doi.org/10.1007/s10753-011-9293-9

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