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Published in:

01-12-2007

Lung Epithelial Cells Modulate the Inflammatory Response of Alveolar Macrophages

Authors: Vardit Rubovitch, Shoham Gershnabel, Moshe Kalina

Published in: Inflammation | Issue 6/2007

Abstract

The goal of this study was to examine the effect of alveolar epithelial cells on inflammatory responses in macrophages. Lung epithelial cells (either rat RLE-6TN or human A549 cells) reduced LPS-induced NO production in alveolar macrophages (AM) in a contact-independent mechanism. The inhibitory effect of the epithelial cells was present already at the transcriptional level: LPS-induced inducible NO synthase (iNOS) expression was significantly smaller. Surfactant protein A (SP-A)-induced NO production by alveolar macrophages was also reduced in the presence of A549 cells, though, by a different kinetics. LPS-induced interleukin-6 (IL-6) production (another inflammatory pathway) by alveolar macrophages was also reduced in the presence of RLE-6TN cells. These data suggest a role for lung epithelial cells in the complicated modulation of inflammatory processes, and provide an insight into the mechanism underlying.

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Title: Lung Epithelial Cells Modulate the Inflammatory Response of Alveolar Macrophages
Authors: Vardit Rubovitch
Shoham Gershnabel
Moshe Kalina
Publication date: 01-12-2007
Publisher: Springer US
Published in: Inflammation / Issue 6/2007
Print ISSN: 0360-3997
Electronic ISSN: 1573-2576
DOI: https://doi.org/10.1007/s10753-007-9042-2

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