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Heart Failure Reviews
Published in: Heart Failure Reviews 1/2018

01-01-2018

Protective molecular mechanisms of clusterin against apoptosis in cardiomyocytes

Authors: Rodrigo Martins Pereira, Rania A. Mekary, Kellen Cristina da Cruz Rodrigues, Chadi Pellegrini Anaruma, Eduardo Rochete Ropelle, Adelino Sanchez Ramos da Silva, Dennys Esper Cintra, José Rodrigo Pauli, Leandro Pereira de Moura

Published in: Heart Failure Reviews | Issue 1/2018

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Abstract

Loss of cardiomyocytes occurs with aging and contributes to cardiovascular complications. In the present study, we highlighted the role of clusterin, a protein that has recently been associated with the protection of cardiomyocytes from apoptosis. Clusterin protects cardiac cells against damage from myocardial infarction, transplant, or myocarditis. Clusterin can act directly or indirectly on apoptosis by regulating several intracellular pathways. These pathways include (1) the oxidant and inflammatory program, (2) insulin growth factor 1 (IGF-1) pathway, (3) KU70 / BCL-2-associated X protein (BAX) pathway, (4) tumor necrosis factor alpha (TNF-α) pathway, (5) BCL-2 antagonist of cell death (BAD) pathway, and (6) mitogen-activated protein kinase (MAPK) pathway. Given the key role of clusterin in preventing loss of cardiac tissue, modulating the expression and function of this protein carries the potential of improving cardiovascular care in the future.
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Metadata
Title
Protective molecular mechanisms of clusterin against apoptosis in cardiomyocytes
Authors
Rodrigo Martins Pereira
Rania A. Mekary
Kellen Cristina da Cruz Rodrigues
Chadi Pellegrini Anaruma
Eduardo Rochete Ropelle
Adelino Sanchez Ramos da Silva
Dennys Esper Cintra
José Rodrigo Pauli
Leandro Pereira de Moura
Publication date
01-01-2018
Publisher
Springer US
Published in
Heart Failure Reviews / Issue 1/2018
Print ISSN: 1382-4147
Electronic ISSN: 1573-7322
DOI
https://doi.org/10.1007/s10741-017-9654-z

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