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01-02-2021 | Metoprolol | Original Research Article

Assessment of the safety of intravitreal injection of metoprolol tartrate in rabbits

Authors: Mayara Rodrigues Brandão de Paiva, Raquel Gregório Arribada, Carolina Nunes da Silva, Marcela Coelho Silva Ribeiro, Rodrigo Jorge, Silvia Ligório Fialho, Armando Silva-Cunha

Published in: Documenta Ophthalmologica | Issue 1/2021

Abstract

Purpose

To verify the safety of different doses of intravitreal metoprolol tartrate (MT) after intravitreal injection in rabbit eyes.

Methods

Animals were randomly assigned into 2 groups: group I received 50 µg of MT and group II 100 µg of MT. A volume of 0.05 mL of the drug solution was administered through an intravitreal injection, while the control eyes received an equal volume of saline solution. Safety was assessed by clinical observation, electroretinography (ERG) and histological evaluation.

Results

No evidence of clinical toxicity was observed. ERG waveforms from the MT treated eyes were similar to those recorded from the control eyes in dark-adapted state, amplitude and the implicit time are similar between the groups in light-adapted state, and their retinas had no signs of toxicity by histological evaluation 7 days after intravitreal injection.

Conclusions

The intravitreal use of metoprolol at 50 and 100 µg dosages does not cause short-term retinal toxicity in rabbits.

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Title: Assessment of the safety of intravitreal injection of metoprolol tartrate in rabbits
Authors: Mayara Rodrigues Brandão de Paiva
Raquel Gregório Arribada
Carolina Nunes da Silva
Marcela Coelho Silva Ribeiro
Rodrigo Jorge
Silvia Ligório Fialho
Armando Silva-Cunha
Publication date: 01-02-2021
Publisher: Springer Berlin Heidelberg
Keywords: Metoprolol
Hemangioma
Hemangioma
Hemangioma
Hemangioma
Hemangioma
Published in: Documenta Ophthalmologica / Issue 1/2021
Print ISSN: 0012-4486
Electronic ISSN: 1573-2622
DOI: https://doi.org/10.1007/s10633-020-09781-0

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Assessment of the safety of intravitreal injection of metoprolol tartrate in rabbits

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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