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Digestive Diseases and Sciences
Published in: Digestive Diseases and Sciences 8/2022

17-05-2022 | Infliximab | Multicenter Seminars: IBD (MUSE: IBD)

Clinical Challenge: Proactive Precise Management of Active Ulcerative Colitis During Pregnancy—Advantages of Point-of-Care Intestinal Ultrasound and Therapeutic Drug Monitoring

Authors: Zoë S. Gottlieb, Michael Dolinger, Maia Kayal, Bhavana Bhagya Rao, Abhik Bhattacharya, Marla C. Dubinsky, Ryan C. Ungaro

Published in: Digestive Diseases and Sciences | Issue 8/2022

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Excerpt

A 36-year-old woman with a history of pan-ulcerative colitis (UC) complicated by erythema nodosum presented at 14 weeks gestation following successful in vitro fertilization (IVF) with several months of increased stool frequency, urgency, and bleeding. …
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Torgersen KL, Curran CA. A systematic approach to the physiologic adaptations of pregnancy. Crit Care Nurs Q 2006;29:2–19.CrossRef
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Gottlieb ZS, O-Hara S, Riggs AR, Monroe J, Mella MT, Dubinsky MC. Trends in common laboratory markers during pregnancy in women with quiescent IBD. Gastroenterology 2020;158:S-447.
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Allocca M et al. Point-of-care ultrasound in inflammatory bowel disease. J Crohns Colitis 2021;15:143–151.CrossRef
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De Voogd F, et al. Intestinal ultrasound to evaluate treatment response during pregnancy in patients with inflammatory bowel disease. Inflamm Bowel Dis. 2021.
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Papamichael K et al. Therapeutic drug monitoring with biologic agents in immune mediated inflammatory diseases. Expert Rev Clin Immunol 2019;15:837–848.CrossRef
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Papamichael K et al. Infliximab concentration thresholds during induction therapy are associated with short-term mucosal healing in patients with ulcerative colitis. Clin Gastroenterol Hepatol 2016;14:543–549.CrossRef
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Papamichael K et al. Therapeutic drug monitoring during induction of anti-tumor necrosis factor therapy in inflammatory bowel disease: defining a therapeutic drug window. Inflamm Bowel Dis 2017;23:1510–1515.CrossRef
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Dubinsky MC et al. Dashboard-driven accelerated infliximab induction dosing increases infliximab durability and reduces immunogenicity. Inflamm Bowel Dis. 2022.
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Metadata
Title
Clinical Challenge: Proactive Precise Management of Active Ulcerative Colitis During Pregnancy—Advantages of Point-of-Care Intestinal Ultrasound and Therapeutic Drug Monitoring
Authors
Zoë S. Gottlieb
Michael Dolinger
Maia Kayal
Bhavana Bhagya Rao
Abhik Bhattacharya
Marla C. Dubinsky
Ryan C. Ungaro
Publication date
17-05-2022
Publisher
Springer US
Published in
Digestive Diseases and Sciences / Issue 8/2022
Print ISSN: 0163-2116
Electronic ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-022-07532-6

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