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Digestive Diseases and Sciences
Published in: Digestive Diseases and Sciences 7/2022

30-05-2022 | DDS Citation Classics

The GI Effects of GLP-1 – The Genesis of Longstanding Progress

Author: Jonathan D. Kaunitz

Published in: Digestive Diseases and Sciences | Issue 7/2022

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Excerpt

Behind every major discovery is a backstory of scientific advances that created the technology and knowledge that provided the substrate on which creativity, innovation, and persistence generated a paradigm shift that radically changes the approach to a disease entity. Such is the case for the discovery of the glucagon-like peptides (GLP), whose stable analogs have immeasurably contributed to the therapy of metabolic diseases and intestinal failure [1‐3]. …
Literature
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Sandoval DA, D’Alessio DA. Physiology of proglucagon peptides: role of glucagon and GLP-1 in health and disease. Physiol Rev 2015;95:513–548.CrossRef
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Blumenstein I. GLP-2 Analogues as First Specific Treatment of Intestinal Failure. Visc Med 2019;35:320–323.CrossRef
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Meier JJ. GLP-1 receptor agonists for individualized treatment of type 2 diabetes mellitus. Nat Rev Endocrinol 2012;8:728–742.CrossRef
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Wettergren A, Schjoldager B, Mortensen PE, Myhre J, Christiansen J, Holst JJ. Truncated GLP-1 (proglucagon 78–107-amide) inhibits gastric and pancreatic functions in man. Dig Dis Sci 1993;38:665–673.CrossRef
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Rehfeld JF, Heding LG, Holst JJ. Increased gut glucagon release as pathogenetic factor in reactive hypoglycaemia? Lancet 1973;1:116–118.CrossRef
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Edman P. Method for determination of amino acid sequence in peptides. Acta Chemica Scand. 1950;4:283–293.CrossRef
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Edman P. A method for the determination of amino acid sequence in peptides. Arch Biochem 1949;22:475.PubMed
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Metadata
Title
The GI Effects of GLP-1 – The Genesis of Longstanding Progress
Author
Jonathan D. Kaunitz
Publication date
30-05-2022
Publisher
Springer US
Published in
Digestive Diseases and Sciences / Issue 7/2022
Print ISSN: 0163-2116
Electronic ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-022-07520-w

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