Top

Digestive Diseases and Sciences

Published in:

01-03-2019 | Correspondence

Nonalcoholic Fatty Liver Disease and Bone Mineral Density in Children and Adolescents: Specific Considerations for Future Studies

Author: Alessandro Mantovani

Published in: Digestive Diseases and Sciences | Issue 3/2019

Excerpt

Dear Editor, …

Byrne CD, Targher G. NAFLD: a multisystem disease. J Hepatol. 2015;62:S47–S64.CrossRefPubMed

Younossi Z, Anstee QM, Marietti M, et al. Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention. Nat Rev Gastroenterol Hepatol. 2018;15:11–20.CrossRefPubMed

Nobili V, Svegliati-Baroni G, Alisi A, Miele L, Valenti L, Vajro P. A 360-degree overview of paediatric NAFLD: recent insights. J Hepatol. 2013;58:1218–1229.CrossRefPubMed

Adams LA, Anstee QM, Tilg H, Targher G. Non-alcoholic fatty liver disease and its relationship with cardiovascular disease and other extra-hepatic diseases. Gut. 2017;66:1138–1153.CrossRefPubMed

Targher G, Lonardo A, Byrne CD. Nonalcoholic fatty liver disease and chronic vascular complications of diabetes mellitus. Nat Rev Endocrinol. 2018;14:99–114.CrossRef

Anstee QM, Mantovani A, Tilg H, Targher G. Risk of cardiomyopathy and cardiac arrhythmias in patients with nonalcoholic fatty liver disease. Nat Rev Gastroenterol Hepatol. 2018;15:425–439.CrossRefPubMed

Targher G, Lonardo A, Rossini M. Nonalcoholic fatty liver disease and decreased bone mineral density: Is there a link? J Endocrinol Investig. 2015;38:817–825.CrossRef

Upala S, Jaruvongvanich V, Wijarnpreecha K, Sanguankeo A. Nonalcoholic fatty liver disease and osteoporosis: a systematic review and meta-analysis. J Bone Miner Metab. 2017;35:685–693.CrossRefPubMed

Pirgon O, Bilgin H, Tolu I, Odabas D. Correlation of insulin sensitivity with bone mineral status in obese adolescents with nonalcoholic fatty liver disease. Clin Endocrinol (Oxf). 2011;75:189–195.CrossRef

10.

Pardee PE, Dunn W, Schwimmer JB. Non-alcoholic fatty liver disease is associated with low bone mineral density in obese children. Aliment Pharmacol Ther. 2012;35:248–254.CrossRefPubMed

11.

Campos RM, de Piano A, da Silva PL, et al. The role of pro/anti-inflammatory adipokines on bone metabolism in NAFLD obese adolescents: effects of long-term interdisciplinary therapy. Endocrine. 2012;42:146–156.CrossRef

12.

Pacifico L, Bezzi M, Lombardo CV, et al. Adipokines and C-reactive protein in relation to bone mineralization in pediatric nonalcoholic fatty liver disease. World J Gastroenterol. 2013;19:4007–4014.CrossRefPubMedPubMedCentral

13.

Nobili V, Giorgio V, Liccardo D, et al. Vitamin D levels and liver histological alterations in children with nonalcoholic fatty liver disease. Eur J Endocrinol. 2014;170:547–553.CrossRefPubMed

14.

Chang EJ, Yi DY, Yang HR. Vitamin D status and bone mineral density in obese children with nonalcoholic fatty liver disease. J Korean Med Sci. 2015;30:1821–1827.CrossRefPubMedPubMedCentral

15.

Labayen I, Ruiz JR, Arenaza L, et al. Hepatic fat content and bone mineral density in children with overweight/obesity. Pediatr Res. 2018. https://doi.org/10.1038/s41390-018-0129-2.CrossRefPubMed

16.

Mosca A, Fintini D, Scorletti E, et al. Relationship between non-alcoholic steatohepatitis, PNPLA3 I148 M genotype and bone mineral density in adolescents. Liver Int. 2018. https://doi.org/10.1111/liv.13955.CrossRefPubMed

17.

Bachrach LK. Diagnosis and treatment of pediatric osteoporosis. Curr Opin Endocrinol Diabetes Obes. 2014;21:454–460.CrossRefPubMed

18.

Kelley JC, Crabtree N, Zemel BS. Bone density in the obese child: clinical considerations and diagnostic challenges. Calcif Tissue Int. 2017;100:514–527.CrossRefPubMedPubMedCentral

19.

Vandewalle S, Taes Y, Van Helvoirt M, et al. Bone size and bone strength are increased in obese male adolescents. J Clin Endocrinol Metab. 2013;98:3019–3028.CrossRefPubMed

20.

Tothill P, Laskey MA, Orphanidou CI, van Wijk M. Anomalies in dual energy X-ray absorptiometry measurements of total-body bone mineral during weight change using Lunar, Hologic and Norland instruments. Br J Radiol. 1999;72:661–669.CrossRefPubMed

21.

Golden NH, Abrams SA. Committee on nutrition. Optimizing bone health in children and adolescents. Pediatrics. 2014;134:e1229–e1243.CrossRefPubMed

22.

Prentice A. Nutritional rickets around the world. J Steroid Biochem Mol Biol. 2013;136:201–206.CrossRefPubMed

23.

Brown M. Skeletal muscle and bone: effect of sex steroids and aging. Adv Physiol Educ. 2008;32:120–126.CrossRefPubMed

Title: Nonalcoholic Fatty Liver Disease and Bone Mineral Density in Children and Adolescents: Specific Considerations for Future Studies
Author: Alessandro Mantovani
Publication date: 01-03-2019
Publisher: Springer US
Published in: Digestive Diseases and Sciences / Issue 3/2019
Print ISSN: 0163-2116
Electronic ISSN: 1573-2568
DOI: https://doi.org/10.1007/s10620-018-5370-3

ACC 2024 Congress Coverage

Heart Failure Video

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Nonalcoholic Fatty Liver Disease and Bone Mineral Density in Children and Adolescents: Specific Considerations for Future Studies

Excerpt

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Excerpt

Please log in to get access to this content

Other articles of this Issue 3/2019

BATF Interference Blocks Th17 Cell Differentiation and Inflammatory Response in Hepatitis B Virus Transgenic Mice

Adherence to Two Large-Bore Intravenous Lines in Acute Gastrointestinal Bleeding Is Low

Macrophage Migration Inhibitor Promoted the Intrahepatic Bile Duct Injury in Rats with Severe Acute Pancreatitis

Coming Complications of Nonalcoholic Fatty Liver Disease: Time to GNASH Your Teeth

Ineffective Esophageal Motility Is Associated with Impaired Bolus Clearance but Does Not Correlate with Severity of Dysphagia

The Turn of the Screw: A Tale of Dysphagia

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page