Top

Published in:

01-04-2017 | Paradigm Shifts In Perspectives

Development of Monoclonal Antibodies: The Dawn of mAb Rule

Author: Jonathan D. Kaunitz

Published in: Digestive Diseases and Sciences | Issue 4/2017

Excerpt

Underlying most major therapeutic advances are fundamental discoveries that shake scientific discourse to its core, usually generating Nobel prizes and entirely new fields of study. In this eighth installment of the series entitled “Paradigm Shifts in Perspective,” Drs. Sofia and Rubin highlight the considerable impact that therapeutic monoclonal antibodies (mAbs) have made on gastrointestinal practice. …

McMaster PD, Hudack SS. The formation of agglutinins within lymph nodes. J Exp Med. 1935;61:783–805.CrossRefPubMedPubMedCentral

Harris TN, Grimm E, Mertens E, Ehrich WE. The role of the lymphocyte in antibody formation. J Exp Med. 1945;81:73–83.CrossRefPubMedPubMedCentral

Bjørneboe M, Gormsen H. Experimental studies on the role of plasma cells as antibody producers. 1942. APMIS. 2007;115:440–483.CrossRefPubMed

Moore DH, Kabat EA, Gutman AB. Bence-Jones proteinemia in multiple myeloma. J Clin Invest. 1943;22:67–75.CrossRefPubMedPubMedCentral

Osserman EF, Lawlor DP. Abnormal serum and urine proteins in thirty five cases of multiple myeloma, as studied by filter paper electrophoresis. Am J Med. 1955;18:462–476.CrossRefPubMed

Waldenstrom J. Monoclonal and polyclonal gammopathies and the biological system of gamma globulins. Prog Allergy. 1962;6:320–348.PubMed

Awdeh ZL, Askonas BA, Williamson AR. The homogeneous-gamma-G-immunoglobulin produced by mouse plasmacytoma 5563 and its subsequent heterogeneity in serum. Biochem J. 1967;102:548–553.CrossRefPubMedPubMedCentral

Askonas BA, Williamson AR, Wright BE. Selection of a single antibody-forming cell clone and its propagation in syngeneic mice. Proc Natl Acad Sci USA. 1970;67:1398–1403.CrossRefPubMedPubMedCentral

Köhler G, Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature. 1975;256:495–497.CrossRefPubMed

10.

Liu JK. The history of monoclonal antibody development—progress, remaining challenges and future innovations. Ann Med Surg (Lond). 2014;3:113–116.CrossRef

11.

Smith SL. Ten years of orthoclone OKT3 (muromonab-CD3): a review. J Transpl Coord. 1996;6:109–119.CrossRefPubMed

12.

Danese S, Vuitton L, Peyrin-Biroulet L. Biologic agents for IBD: practical insights. Nat Rev Gastroenterol Hepatol. 2015;12:537–545.CrossRefPubMed

Title: Development of Monoclonal Antibodies: The Dawn of mAb Rule
Author: Jonathan D. Kaunitz
Publication date: 01-04-2017
Publisher: Springer US
Published in: Digestive Diseases and Sciences / Issue 4/2017
Print ISSN: 0163-2116
Electronic ISSN: 1573-2568
DOI: https://doi.org/10.1007/s10620-017-4478-1

ACC 2024 Congress Coverage

Heart Failure Video

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Development of Monoclonal Antibodies: The Dawn of mAb Rule

Excerpt

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Excerpt

Please log in to get access to this content

Other articles of this Issue 4/2017

Determination of Anti-Anisakis Simplex Antibodies and Relationship with αβ and γδ Lymphocyte Subpopulations in Patients with Crohn’s Disease

Overlap of Dyspepsia in Patients with Gastroesophageal Reflux Disease: Impact of Clinical, Metabolic, and Psychosocial Characteristics

Double-Balloon Colonoscopy Has a Higher Cecal Intubation Rate Than Conventional Colonoscopy Using a Colon Simulator

Erratum to: Multicenter Prospective Study on the Safety of Upper Gastrointestinal Endoscopic Procedures in Antithrombotic Drug Users

Interaction of Ethnicity and H. pylori Infection in the Occurrence of Microscopic Colitis

The Efficacy of a Novel Tissue Grasper-Clips Technique for Large Perforations of the Sigmoid Colon in an Experimental Animal Model (Video)

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page