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Published in: Digestive Diseases and Sciences 3/2012

01-03-2012 | Original Article

Gastric Tube Reconstruction Reduces Postoperative Gastroesophageal Reflux in Adenocarcinoma of Esophagogastric Junction

Authors: Xiu-Feng Chen, Bo Zhang, Zhi-Xin Chen, Jian-Kun Hu, Bin Dai, Fang Wang, Hong-Xin Yang, Jia-Ping Chen

Published in: Digestive Diseases and Sciences | Issue 3/2012

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Abstract

Background

The anastomosis of gastric remnant to esophagus after proximal gastrectomy is the traditional surgical treatment procedure for patients with types II and III adenocarcinoma of esophagogastric junction. However, the postoperative complications such as gastroesophageal reflux are frequent.

Aims

To assess the outcome of the intraperitoneal anastomosis of the reconstructed gastric tube to esophagus after proximal gastrectomy for types II and III adenocarcinoma of esophagogastric junction.

Methods

Seventy-six consecutive patients with preoperative diagnosis of type II or type III adenocarcinoma of esophagogastric junction were recruited. Forty-one patients had the traditional anastomosis of gastric remnant to esophagus and 35 patients underwent an anastomosis of esophagus to a gastric tube that was constructed from the gastric remnant after proximal gastrectomy.

Results

Twenty-three (56.1%) versus 12 (28.6%) patients (p = 0.016) complained various discomforts and/or were diagnosed with complications in the traditional group and gastric tube group, respectively, although there were no significant differences between the two groups in demographic data and pathological characteristics. Fourteen (34.1%) versus five (14.3%) patients (p = 0.046) complained of heartburn or acid regurgitation and nine (22.0%) versus two (5.7%) patients (p = 0.045) were confirmed reflux esophagitis in the traditional group and the gastric tube group, respectively.

Conclusions

The intraperitoneal anastomosis of the reconstructed gastric tube to esophagus demonstrates less complaints of gastroesophageal reflux and reflux esophagitis than the traditional anastomosis of gastric remnant to esophagus in the surgical treatment of types II and III adenocarcinoma of esophagogastric junction in 1-year follow-up.
Literature
1.
go back to reference Devesa SS, Blot WJ, Fraumeni JF Jr. Changing patterns in the incidence of esophageal and gastric carcinoma in the United States. Cancer. 1998;83:2049–2053.PubMedCrossRef Devesa SS, Blot WJ, Fraumeni JF Jr. Changing patterns in the incidence of esophageal and gastric carcinoma in the United States. Cancer. 1998;83:2049–2053.PubMedCrossRef
2.
go back to reference Fan YJ, Song X, Li JL, et al. Esophageal and gastric cardia cancers on 4,238 Chinese patients residing in municipal and rural regions: a histopathological comparison during 24-year period. World J Surg. 2008;32:1980–1988.PubMedCrossRef Fan YJ, Song X, Li JL, et al. Esophageal and gastric cardia cancers on 4,238 Chinese patients residing in municipal and rural regions: a histopathological comparison during 24-year period. World J Surg. 2008;32:1980–1988.PubMedCrossRef
3.
go back to reference Hasegawa S, Yoshikawa T. Adenocarcinoma of the esophagogastric junction: incidence, characteristics, and treatment strategies. Gastric Cancer. 2010;13:63–73.PubMedCrossRef Hasegawa S, Yoshikawa T. Adenocarcinoma of the esophagogastric junction: incidence, characteristics, and treatment strategies. Gastric Cancer. 2010;13:63–73.PubMedCrossRef
4.
go back to reference Johansson J, Djerf P, Oberg S, et al. Two different surgical approaches in the treatment of adenocarcinoma at the gastroesophageal junction. World J Surg. 2008;32:1013–1020.PubMedCrossRef Johansson J, Djerf P, Oberg S, et al. Two different surgical approaches in the treatment of adenocarcinoma at the gastroesophageal junction. World J Surg. 2008;32:1013–1020.PubMedCrossRef
5.
go back to reference Barbour AP, Rizk NP, Gonen M, et al. Lymphadenectomy for adenocarcinoma of the gastroesophageal junction (GEJ): impact of adequate staging on outcome. Ann Surg Oncol. 2007;14:306–316.PubMedCrossRef Barbour AP, Rizk NP, Gonen M, et al. Lymphadenectomy for adenocarcinoma of the gastroesophageal junction (GEJ): impact of adequate staging on outcome. Ann Surg Oncol. 2007;14:306–316.PubMedCrossRef
6.
go back to reference Lehmann K, Schneider PM. Differences in the molecular biology of adenocarcinoma of the esophagus, gastric cardia, and upper gastric third. Recent Results Cancer Res. 2010;182:65–72.PubMedCrossRef Lehmann K, Schneider PM. Differences in the molecular biology of adenocarcinoma of the esophagus, gastric cardia, and upper gastric third. Recent Results Cancer Res. 2010;182:65–72.PubMedCrossRef
7.
go back to reference An JY, Youn HG, Choi MG, Noh JH, Sohn TS, Kim S. The difficult choice between total and proximal gastrectomy in proximal early gastric cancer. Am J Surg. 2008;196:587–591.PubMedCrossRef An JY, Youn HG, Choi MG, Noh JH, Sohn TS, Kim S. The difficult choice between total and proximal gastrectomy in proximal early gastric cancer. Am J Surg. 2008;196:587–591.PubMedCrossRef
8.
go back to reference Katai H, Sano T, Fukagawa T, Shinohara H, Sasako M. Prospective study of proximal gastrectomy for early gastric cancer in the upper third of the stomach. Brit J Surg. 2003;90:850–853.PubMedCrossRef Katai H, Sano T, Fukagawa T, Shinohara H, Sasako M. Prospective study of proximal gastrectomy for early gastric cancer in the upper third of the stomach. Brit J Surg. 2003;90:850–853.PubMedCrossRef
9.
go back to reference Shibuya S, Fukudo S, Shineha R, et al. High incidence of reflux esophagitis observed by routine endoscopic examination after gastric pull-up esophagectomy. World J Surg. 2003;27:580–583.PubMedCrossRef Shibuya S, Fukudo S, Shineha R, et al. High incidence of reflux esophagitis observed by routine endoscopic examination after gastric pull-up esophagectomy. World J Surg. 2003;27:580–583.PubMedCrossRef
10.
go back to reference Shiraishi N, Hirose R, Morimoto A, Kawano K, Adachi Y, Kitano S. Gastric tube reconstruction prevented esophageal reflux after proximal gastrectomy. Gastric Cancer. 1998;1:78–79.PubMedCrossRef Shiraishi N, Hirose R, Morimoto A, Kawano K, Adachi Y, Kitano S. Gastric tube reconstruction prevented esophageal reflux after proximal gastrectomy. Gastric Cancer. 1998;1:78–79.PubMedCrossRef
11.
go back to reference Washington K. 7th Edition of the AJCC cancer staging manual: stomach. Ann Surg Oncol. 2010;17:3077–3079.PubMedCrossRef Washington K. 7th Edition of the AJCC cancer staging manual: stomach. Ann Surg Oncol. 2010;17:3077–3079.PubMedCrossRef
12.
go back to reference Armstrong D, Bennett JR, Blum AL, et al. The endoscopic assessment of esophagitis: a progress report on observer agreement. Gastroenterology. 1996;111:85–92.PubMedCrossRef Armstrong D, Bennett JR, Blum AL, et al. The endoscopic assessment of esophagitis: a progress report on observer agreement. Gastroenterology. 1996;111:85–92.PubMedCrossRef
13.
go back to reference Omloo JM, Lagarde SM, Hulscher JB, et al. Extended transthoracic resection compared with limited transhiatal resection for adenocarcinoma of the mid/distal esophagus: five-year survival of a randomized clinical trial. Ann Surg. 2007;246:992–1001.PubMedCrossRef Omloo JM, Lagarde SM, Hulscher JB, et al. Extended transthoracic resection compared with limited transhiatal resection for adenocarcinoma of the mid/distal esophagus: five-year survival of a randomized clinical trial. Ann Surg. 2007;246:992–1001.PubMedCrossRef
14.
go back to reference Carboni F, Lorusso R, Santoro R, et al. Adenocarcinoma of the esophagogastric junction: the role of abdominal-transhiatal resection. Ann Surg Oncol. 2009;16:304–310.PubMedCrossRef Carboni F, Lorusso R, Santoro R, et al. Adenocarcinoma of the esophagogastric junction: the role of abdominal-transhiatal resection. Ann Surg Oncol. 2009;16:304–310.PubMedCrossRef
15.
go back to reference Yoo CH, Sohn BH, Han WK, Pae WK. Long-term results of proximal and total gastrectomy for adenocarcinoma of the upper third of the stomach. Cancer Res Treat. 2004;36:50–55.PubMedCrossRef Yoo CH, Sohn BH, Han WK, Pae WK. Long-term results of proximal and total gastrectomy for adenocarcinoma of the upper third of the stomach. Cancer Res Treat. 2004;36:50–55.PubMedCrossRef
16.
go back to reference Harrison LE, Karpeh MS, Brennan MF. Total gastrectomy is not necessary for proximal gastric cancer. Surgery. 1998;123:127–130.PubMedCrossRef Harrison LE, Karpeh MS, Brennan MF. Total gastrectomy is not necessary for proximal gastric cancer. Surgery. 1998;123:127–130.PubMedCrossRef
17.
go back to reference Shiraishi N, Adachi Y, Kitano S, Kakisako K, Inomata M, Yasuda K. Clinical outcome of proximal versus total gastrectomy for proximal gastric cancer. World J Surg. 2002;26:1150–1154.PubMedCrossRef Shiraishi N, Adachi Y, Kitano S, Kakisako K, Inomata M, Yasuda K. Clinical outcome of proximal versus total gastrectomy for proximal gastric cancer. World J Surg. 2002;26:1150–1154.PubMedCrossRef
18.
go back to reference Aihara R, Mochiki E, Ohno T, et al. Laparoscopy-assisted proximal gastrectomy with gastric tube reconstruction for early gastric cancer. Surg Endosc. 2010;24:2343–2348.PubMedCrossRef Aihara R, Mochiki E, Ohno T, et al. Laparoscopy-assisted proximal gastrectomy with gastric tube reconstruction for early gastric cancer. Surg Endosc. 2010;24:2343–2348.PubMedCrossRef
19.
go back to reference Sakamoto T, Fujimaki M, Tazawa K. Ileocolon interposition as a substitute stomach after total or proximal gastrectomy. Ann Surg. 1997;226:139–145.PubMedCrossRef Sakamoto T, Fujimaki M, Tazawa K. Ileocolon interposition as a substitute stomach after total or proximal gastrectomy. Ann Surg. 1997;226:139–145.PubMedCrossRef
20.
go back to reference Kim EM, Jeong HY, Lee ES, et al. Comparison between proximal gastrectomy and total gastrectomy in early gastric cancer. Korean J Gastroenterol/Taehan Sohwagi Hakhoe Chi. 2009;54:212–219. Kim EM, Jeong HY, Lee ES, et al. Comparison between proximal gastrectomy and total gastrectomy in early gastric cancer. Korean J Gastroenterol/Taehan Sohwagi Hakhoe Chi. 2009;54:212–219.
21.
go back to reference Kim HK, Choi YH, Shim JH, et al. Endoscopic evaluation of the quality of the anastomosis after esophagectomy with gastric tube reconstruction. World J Surg. 2008;32:2010–2014.PubMedCrossRef Kim HK, Choi YH, Shim JH, et al. Endoscopic evaluation of the quality of the anastomosis after esophagectomy with gastric tube reconstruction. World J Surg. 2008;32:2010–2014.PubMedCrossRef
22.
go back to reference Ikeda Y, Niimi M, Kan S, Shatari T, Takami H, Kodaira S. Clinical significance of tissue blood flow during esophagectomy by laser Doppler flowmetry. J Thorac Cardiovasc Surg. 2001;122:1101–1106.PubMedCrossRef Ikeda Y, Niimi M, Kan S, Shatari T, Takami H, Kodaira S. Clinical significance of tissue blood flow during esophagectomy by laser Doppler flowmetry. J Thorac Cardiovasc Surg. 2001;122:1101–1106.PubMedCrossRef
24.
go back to reference Kojima K, Yamada H, Inokuchi M, Kawano T, Sugihara K. Functional evaluation after vagus-nerve-sparing laparoscopically assisted distal gastrectomy. Surg Endosc. 2008;22:2003–2008.PubMedCrossRef Kojima K, Yamada H, Inokuchi M, Kawano T, Sugihara K. Functional evaluation after vagus-nerve-sparing laparoscopically assisted distal gastrectomy. Surg Endosc. 2008;22:2003–2008.PubMedCrossRef
25.
go back to reference Kolh P, Honore P, Degauque C, Gielen J, Gerard P, Jacquet N. Early stage results after oesophageal resection for malignancy—colon interposition vs. gastric pull-up. Eur J Cardio Thorac Surg. 2000;18:293–300.CrossRef Kolh P, Honore P, Degauque C, Gielen J, Gerard P, Jacquet N. Early stage results after oesophageal resection for malignancy—colon interposition vs. gastric pull-up. Eur J Cardio Thorac Surg. 2000;18:293–300.CrossRef
26.
go back to reference Walther B, Johansson J, Johnsson F, Von Holstein CS, Zilling T. Cervical or thoracic anastomosis after esophageal resection and gastric tube reconstruction: a prospective randomized trial comparing sutured neck anastomosis with stapled intrathoracic anastomosis. Ann Surg. 2003;238:803–812; discussion 812–804. Walther B, Johansson J, Johnsson F, Von Holstein CS, Zilling T. Cervical or thoracic anastomosis after esophageal resection and gastric tube reconstruction: a prospective randomized trial comparing sutured neck anastomosis with stapled intrathoracic anastomosis. Ann Surg. 2003;238:803–812; discussion 812–804.
27.
go back to reference Nagaya M, Kato J, Niimi N, Tanaka S, Iio K. Proposal of a novel method to evaluate anastomotic tension in esophageal atresia with a distal tracheoesophageal fistula. Pediatric Surg Int. 2005;21:780–785.CrossRef Nagaya M, Kato J, Niimi N, Tanaka S, Iio K. Proposal of a novel method to evaluate anastomotic tension in esophageal atresia with a distal tracheoesophageal fistula. Pediatric Surg Int. 2005;21:780–785.CrossRef
28.
go back to reference Yajima K, Kosugi S, Kanda T, Matsuki A, Hatakeyama K. Risk factors of reflux esophagitis in the cervical remnant following esophagectomy with gastric tube reconstruction. World J Surg. 2009;33:284–289.PubMedCrossRef Yajima K, Kosugi S, Kanda T, Matsuki A, Hatakeyama K. Risk factors of reflux esophagitis in the cervical remnant following esophagectomy with gastric tube reconstruction. World J Surg. 2009;33:284–289.PubMedCrossRef
29.
go back to reference Adachi Y, Inoue T, Hagino Y, Shiraishi N, Shimoda K, Kitano S. Surgical results of proximal gastrectomy for early-stage gastric cancer: jejunal interposition and gastric tube reconstruction. Gastric Cancer. 1999;2:40–45.PubMedCrossRef Adachi Y, Inoue T, Hagino Y, Shiraishi N, Shimoda K, Kitano S. Surgical results of proximal gastrectomy for early-stage gastric cancer: jejunal interposition and gastric tube reconstruction. Gastric Cancer. 1999;2:40–45.PubMedCrossRef
30.
go back to reference Nesbakken A, Nygaard K, Westerheim O, Lunde OC, Mala T. Audit of intraoperative and early postoperative complications after introduction of mesorectal excision for rectal cancer. Eur J Surg. 2002;168:229–235.PubMedCrossRef Nesbakken A, Nygaard K, Westerheim O, Lunde OC, Mala T. Audit of intraoperative and early postoperative complications after introduction of mesorectal excision for rectal cancer. Eur J Surg. 2002;168:229–235.PubMedCrossRef
31.
go back to reference Viklund P, Lindblad M, Lu M, Ye W, Johansson J, Lagergren J. Risk factors for complications after esophageal cancer resection: a prospective population-based study in Sweden. Ann Surg. 2006;243:204–211.PubMedCrossRef Viklund P, Lindblad M, Lu M, Ye W, Johansson J, Lagergren J. Risk factors for complications after esophageal cancer resection: a prospective population-based study in Sweden. Ann Surg. 2006;243:204–211.PubMedCrossRef
32.
go back to reference Lehnert T, Cardona S, Hinz U, et al. Primary and locally recurrent retroperitoneal soft-tissue sarcoma: local control and survival. Eur J Surg Oncol. 2009;35:986–993.PubMedCrossRef Lehnert T, Cardona S, Hinz U, et al. Primary and locally recurrent retroperitoneal soft-tissue sarcoma: local control and survival. Eur J Surg Oncol. 2009;35:986–993.PubMedCrossRef
33.
go back to reference Lo CM, Fan ST, Liu CL, Lai EC, Wong J. Biliary complications after hepatic resection: risk factors, management, and outcome. Arch Surg. 1998;133:156–161.PubMedCrossRef Lo CM, Fan ST, Liu CL, Lai EC, Wong J. Biliary complications after hepatic resection: risk factors, management, and outcome. Arch Surg. 1998;133:156–161.PubMedCrossRef
34.
go back to reference Yasuda K, Shiraishi N, Adachi Y, Inomata M, Sato K, Kitano S. Risk factors for complications following resection of large gastric cancer. Br J Surg. 2001;88:873–877.PubMedCrossRef Yasuda K, Shiraishi N, Adachi Y, Inomata M, Sato K, Kitano S. Risk factors for complications following resection of large gastric cancer. Br J Surg. 2001;88:873–877.PubMedCrossRef
35.
go back to reference Blumberg N, Agarwal MM, Chuang C. Relation between recurrence of cancer of the colon and blood transfusion. Br Med J (Clin Res Ed). 1985;290:1037–1039.CrossRef Blumberg N, Agarwal MM, Chuang C. Relation between recurrence of cancer of the colon and blood transfusion. Br Med J (Clin Res Ed). 1985;290:1037–1039.CrossRef
36.
go back to reference McAlister FA, Clark HD, Wells PS, Laupacis A. Perioperative allogeneic blood transfusion does not cause adverse sequelae in patients with cancer: a meta-analysis of unconfounded studies. Brit J Surg. 1998;85:171–178.PubMedCrossRef McAlister FA, Clark HD, Wells PS, Laupacis A. Perioperative allogeneic blood transfusion does not cause adverse sequelae in patients with cancer: a meta-analysis of unconfounded studies. Brit J Surg. 1998;85:171–178.PubMedCrossRef
37.
go back to reference Michiura T, Nakane Y, Kanbara T, et al. Assessment of the preserved function of the remnant stomach in pylorus-preserving gastrectomy by gastric emptying scintigraphy. World J Surg. 2006;30:1277–1283.PubMedCrossRef Michiura T, Nakane Y, Kanbara T, et al. Assessment of the preserved function of the remnant stomach in pylorus-preserving gastrectomy by gastric emptying scintigraphy. World J Surg. 2006;30:1277–1283.PubMedCrossRef
38.
go back to reference Kodama Y, Zhao CM, Kulseng B, Chen D. Eating behavior in rats subjected to vagotomy, sleeve gastrectomy, and duodenal switch. J Gastrointest Surg. 2010;14:1502–1510.PubMedCrossRef Kodama Y, Zhao CM, Kulseng B, Chen D. Eating behavior in rats subjected to vagotomy, sleeve gastrectomy, and duodenal switch. J Gastrointest Surg. 2010;14:1502–1510.PubMedCrossRef
39.
go back to reference Tanizawa Y, Bando E, Kawamura T, et al. Influence of a positive proximal margin on oral intake in patients with palliative gastrectomy for far advanced gastric cancer. World J Surg. 2011;35:1030–1034.PubMedCrossRef Tanizawa Y, Bando E, Kawamura T, et al. Influence of a positive proximal margin on oral intake in patients with palliative gastrectomy for far advanced gastric cancer. World J Surg. 2011;35:1030–1034.PubMedCrossRef
40.
go back to reference Yuasa N, Miyake H, Yamada T, Ebata T, Nimura Y, Hattori T. Clinicopathologic comparison of Siewert type II and III adenocarcinomas of the gastroesophageal junction. World J Surg. 2006;30:364–371.PubMedCrossRef Yuasa N, Miyake H, Yamada T, Ebata T, Nimura Y, Hattori T. Clinicopathologic comparison of Siewert type II and III adenocarcinomas of the gastroesophageal junction. World J Surg. 2006;30:364–371.PubMedCrossRef
41.
go back to reference Gaca JG, Petersen RP, Peterson BL, et al. Pathologic nodal status predicts disease-free survival after neoadjuvant chemoradiation for gastroesophageal junction carcinoma. Ann Surg Oncol. 2006;13:340–346.PubMedCrossRef Gaca JG, Petersen RP, Peterson BL, et al. Pathologic nodal status predicts disease-free survival after neoadjuvant chemoradiation for gastroesophageal junction carcinoma. Ann Surg Oncol. 2006;13:340–346.PubMedCrossRef
Metadata
Title
Gastric Tube Reconstruction Reduces Postoperative Gastroesophageal Reflux in Adenocarcinoma of Esophagogastric Junction
Authors
Xiu-Feng Chen
Bo Zhang
Zhi-Xin Chen
Jian-Kun Hu
Bin Dai
Fang Wang
Hong-Xin Yang
Jia-Ping Chen
Publication date
01-03-2012
Publisher
Springer US
Published in
Digestive Diseases and Sciences / Issue 3/2012
Print ISSN: 0163-2116
Electronic ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-011-1920-7

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