Skip to main content
Top
Published in: World Journal of Surgery 2/2009

01-02-2009

Risk Factors of Reflux Esophagitis in the Cervical Remnant Following Esophagectomy with Gastric Tube Reconstruction

Authors: Kazuhito Yajima, Shin-ichi Kosugi, Tatsuo Kanda, Atsushi Matsuki, Katsuyoshi Hatakeyama

Published in: World Journal of Surgery | Issue 2/2009

Login to get access

Abstract

Background

The risk factors and suitable treatment of reflux esophagitis (RE) of the cervical remnant in patients undergoing radical esophagectomy remain unclear. The aim of this study was to evaluate the risk factors in patients with RE in the cervical remnant.

Methods

We retrospectively examined 141 consecutive patients who underwent esophagectomy and reconstruction with gastric tubing. RE was diagnosed by upper gastrointestinal endoscopy and graded according to the Los Angeles Classification. Statistically, 11 potential risk factors of RE were evaluated. The postoperative follow-up time ranged from 18 to 204 months (median 60 months).

Results

Among a total of 141 patients, 48 (34%) had RE in the cervical remnant, with 14 (29%) cases categorized as grade B, nine (19%) as grade C, and 25 (52%) as grade D. The cumulative incidence of RE in the cervical remnant was 24% at 5 years after surgery and 60% at 10 years, respectively. Pyloroplasty and bile reflux were identified as independent risk factors of RE in the cervical remnant by univariate and multivariate analyses.

Conclusions

The results of this study show a high incidence and high grade of RE in the cervical remnant after esophagectomy. Routine endoscopic examination and suitable medication is required for the control of RE in the cervical remnant together with surgical procedures to avoid bile reflux.
Literature
1.
go back to reference Ando N, Ozawa S, Kitagawa Y et al (2000) Improvement in the results of surgical treatment of advanced squamous esophageal carcinoma during 15 consecutive years. Ann Surg 232:225–235PubMedCrossRef Ando N, Ozawa S, Kitagawa Y et al (2000) Improvement in the results of surgical treatment of advanced squamous esophageal carcinoma during 15 consecutive years. Ann Surg 232:225–235PubMedCrossRef
2.
go back to reference Law S, Kwong DL, Kwok KF et al (2003) Improvement in treatment results and long-term survival of patients with esophageal cancer: impact of chemoradiation and change in treatment strategy. Ann Surg 238:339–347PubMed Law S, Kwong DL, Kwok KF et al (2003) Improvement in treatment results and long-term survival of patients with esophageal cancer: impact of chemoradiation and change in treatment strategy. Ann Surg 238:339–347PubMed
3.
go back to reference Akiyama H, Tsurumaru M, Udagawa H et al (1994) Radical lymph node dissection for cancer of the thoracic esophagus. Ann Surg 220:364–373PubMedCrossRef Akiyama H, Tsurumaru M, Udagawa H et al (1994) Radical lymph node dissection for cancer of the thoracic esophagus. Ann Surg 220:364–373PubMedCrossRef
5.
go back to reference Gutshow C, Collard JM, Romagnoli R et al (2001) Denervated stomach as an esophageal substitute recovers intraluminal acidity with time. Ann Surg 223:509–514CrossRef Gutshow C, Collard JM, Romagnoli R et al (2001) Denervated stomach as an esophageal substitute recovers intraluminal acidity with time. Ann Surg 223:509–514CrossRef
6.
go back to reference Okada N, Sakurai T, Tsuchihashi S et al (1986) Gastric function in patients with intrathoracic stomach after esophageal surgery. Ann Surg 204:114–121PubMedCrossRef Okada N, Sakurai T, Tsuchihashi S et al (1986) Gastric function in patients with intrathoracic stomach after esophageal surgery. Ann Surg 204:114–121PubMedCrossRef
7.
go back to reference Yamamoto S, Makuuchi H, Shimada H et al (2007) Clinical analysis of reflux esophagitis following esophagectomy with gastric tube reconstruction. J Gastroenterol 42:342–345PubMedCrossRef Yamamoto S, Makuuchi H, Shimada H et al (2007) Clinical analysis of reflux esophagitis following esophagectomy with gastric tube reconstruction. J Gastroenterol 42:342–345PubMedCrossRef
8.
go back to reference Shibuya S, Fukudo S, Shineha R et al (2003) High incidence of reflux esophagitis observed by routine endoscopic examination after gastric pull-up esophagectomy. World J Surg 27:580–583PubMedCrossRef Shibuya S, Fukudo S, Shineha R et al (2003) High incidence of reflux esophagitis observed by routine endoscopic examination after gastric pull-up esophagectomy. World J Surg 27:580–583PubMedCrossRef
9.
go back to reference Armstrong D, Bennett JR, Blum AL et al (1996) The endoscopic assessment esophagitis: a progress report on observer agreement. Gastroenterology 111:85–92PubMedCrossRef Armstrong D, Bennett JR, Blum AL et al (1996) The endoscopic assessment esophagitis: a progress report on observer agreement. Gastroenterology 111:85–92PubMedCrossRef
10.
go back to reference Green FL, Page DL, Fleming ID et al (2002) American joint committee on cancer staging manual, 6th edn. Springer, New York, pp 91–95 Green FL, Page DL, Fleming ID et al (2002) American joint committee on cancer staging manual, 6th edn. Springer, New York, pp 91–95
11.
go back to reference Isono K, Sato H, Nakayama K (1991) Results of a nationwide study on the three-field lymph node dissection of esophageal cancer. Oncology 48:411–420PubMedCrossRef Isono K, Sato H, Nakayama K (1991) Results of a nationwide study on the three-field lymph node dissection of esophageal cancer. Oncology 48:411–420PubMedCrossRef
12.
go back to reference Nishimaki T, Tanaka O, Suzuki T et al (1994) Clinical implications of cervical lymph node metastasis patterns in thoracic esophageal cancer. Ann Surg 220:775–781PubMedCrossRef Nishimaki T, Tanaka O, Suzuki T et al (1994) Clinical implications of cervical lymph node metastasis patterns in thoracic esophageal cancer. Ann Surg 220:775–781PubMedCrossRef
13.
go back to reference Demeester TR, Johansson KE, Frantze I et al (1988) Indications, surgical technique, and long-term functional results of colon interposition or bypass. Ann Surg 208:460–474PubMedCrossRef Demeester TR, Johansson KE, Frantze I et al (1988) Indications, surgical technique, and long-term functional results of colon interposition or bypass. Ann Surg 208:460–474PubMedCrossRef
14.
go back to reference Urschel JD, Blewett CJ, Young JE et al (2002) Pyloric drainage (pyloroplasty) or no drainage in gastric reconstruction after esophagectomy: a meta-analysis of randomized controlled trials. Dig Surg 19:160–164PubMedCrossRef Urschel JD, Blewett CJ, Young JE et al (2002) Pyloric drainage (pyloroplasty) or no drainage in gastric reconstruction after esophagectomy: a meta-analysis of randomized controlled trials. Dig Surg 19:160–164PubMedCrossRef
15.
go back to reference Romagnoli R, Bechi P, Salizzoni M et al (1999) Combined 24-hour intraluminal pH and bile monitoring of the denervated whole stomach as an esophageal substitute. Hepatogastroenterology 46:86–91PubMed Romagnoli R, Bechi P, Salizzoni M et al (1999) Combined 24-hour intraluminal pH and bile monitoring of the denervated whole stomach as an esophageal substitute. Hepatogastroenterology 46:86–91PubMed
16.
go back to reference Okuyama M, Motoyama S, Maruyama K et al (2008) Proton pump inhibitors relieve and prevent symptoms related to gastric acidity after esophagectomy. World J Surg 32:246–254PubMedCrossRef Okuyama M, Motoyama S, Maruyama K et al (2008) Proton pump inhibitors relieve and prevent symptoms related to gastric acidity after esophagectomy. World J Surg 32:246–254PubMedCrossRef
Metadata
Title
Risk Factors of Reflux Esophagitis in the Cervical Remnant Following Esophagectomy with Gastric Tube Reconstruction
Authors
Kazuhito Yajima
Shin-ichi Kosugi
Tatsuo Kanda
Atsushi Matsuki
Katsuyoshi Hatakeyama
Publication date
01-02-2009
Publisher
Springer-Verlag
Published in
World Journal of Surgery / Issue 2/2009
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI
https://doi.org/10.1007/s00268-008-9856-6

Other articles of this Issue 2/2009

World Journal of Surgery 2/2009 Go to the issue