Skip to main content
Top
Published in: Digestive Diseases and Sciences 9/2011

01-09-2011 | Original Article

Comparison of Self-Expanding Metal Stents and Urgent Surgery for Left-Sided Malignant Colonic Obstruction in Elderly Patients

Authors: Ming-gao Guo, Yi Feng, Qi Zheng, Jian-zhong Di, Yu Wang, You-ben Fan, Xin-Yu Huang

Published in: Digestive Diseases and Sciences | Issue 9/2011

Login to get access

Abstract

Background

Acute left-sided malignant colonic obstruction is common in elderly patients and multiple treatment options exist. To date, the use of self-expanding metallic stents (SEMS) in elderly patients has not been adequately described.

Aims

The purpose of this study was to compare mortality, avoidance of stoma, and short-term survival in elderly patients with malignant bowel obstruction treated with either colonic stenting or surgery.

Methods

In this retrospective review, elderly patients with acute left-sided colonic obstruction cancer underwent either insertion of a SEMS (n = 34) or primary surgery (n = 58). The two groups were compared for clinic variables, surgical procedures and outcome, acute mortality, and complications.

Results

Both groups were similar in terms of age, sex, tumor distribution, ASA grade, and comorbidities. The SEMS were successful placed in 91% of patients,and surgery was effective in relieving obstruction in 100% of the patients. Primary anastomosis was 79% in the SEMS group compared to 47% in the primary surgery group (P = 0.002). Secondary reanastomosis was 31% in the primary surgery group but only 3% in the SEMS surgery group (P = 0.001). Patients in the SEMS group had less 30-day mortality compared to the primary surgery group (3% vs. 19%, P = 0.03). Postoperative complications were similar.

Conclusions

In elderly patients with acute left-sided colonic obstruction cancer due to colorectal cancer, SEMS provide an effective and safe therapeutic option compared to emergent surgery.
Literature
1.
go back to reference Aapro MS, Kohne CH, Cohen HJ, Extermann M. Never too old? Age should not be a barrier to enrollment in cancer clinical trials. Oncologist. 2005;10:198–204.PubMedCrossRef Aapro MS, Kohne CH, Cohen HJ, Extermann M. Never too old? Age should not be a barrier to enrollment in cancer clinical trials. Oncologist. 2005;10:198–204.PubMedCrossRef
2.
go back to reference Folprecht G, Cunningham D, Ross P, et al. Efficacy of 5-fluorouracil-based chemotherapy in elderly patients with metastatic colorectal cancer: a pooled analysis of clinical trials. Ann Oncol. 2004;15:1330–1338.PubMedCrossRef Folprecht G, Cunningham D, Ross P, et al. Efficacy of 5-fluorouracil-based chemotherapy in elderly patients with metastatic colorectal cancer: a pooled analysis of clinical trials. Ann Oncol. 2004;15:1330–1338.PubMedCrossRef
3.
go back to reference Riedl S, Wiebelt H, Bergmann U, Hermanek P Jr. Postoperative complications and fatalities in surgical therapy of colon carcinoma. Results of the German multicenter study by the colorectal carcinoma study group. Chirurg. 1995;66:597–606.PubMed Riedl S, Wiebelt H, Bergmann U, Hermanek P Jr. Postoperative complications and fatalities in surgical therapy of colon carcinoma. Results of the German multicenter study by the colorectal carcinoma study group. Chirurg. 1995;66:597–606.PubMed
4.
go back to reference Mulcahy HE, Patchett SE, Daly L, O’Donoghue DR. Prognosis of elderly patients with large bowel cancer. Br J Surg. 1994;81:419–421.CrossRef Mulcahy HE, Patchett SE, Daly L, O’Donoghue DR. Prognosis of elderly patients with large bowel cancer. Br J Surg. 1994;81:419–421.CrossRef
5.
go back to reference Morel PH, Egeli RA, Wachtl S, Rohner A. Results of operative treatment of gastrointestinal tract tumors in patients over 80 years of age. Arch Surg. 1989;124:662–664.PubMed Morel PH, Egeli RA, Wachtl S, Rohner A. Results of operative treatment of gastrointestinal tract tumors in patients over 80 years of age. Arch Surg. 1989;124:662–664.PubMed
6.
go back to reference Spivak H, Maele DV, Friedman I, Nussbaum M. Colorectal surgery in octogenarians. J Am Coll Surg. 1996;183:46–50.PubMed Spivak H, Maele DV, Friedman I, Nussbaum M. Colorectal surgery in octogenarians. J Am Coll Surg. 1996;183:46–50.PubMed
7.
go back to reference Dohmoto M. New method: endoscopic implantation of rectal stent in palliative treatment of malignant stenosis. Endoscopia Digestiva. 1991;3:1507–1512. Dohmoto M. New method: endoscopic implantation of rectal stent in palliative treatment of malignant stenosis. Endoscopia Digestiva. 1991;3:1507–1512.
8.
go back to reference Martinez-Santos C, Lobato RF, Fradejas JM, Pinto I, Ortega-Deballón P, Moreno-Azcoita M. Self expandable stent before elective surgery vs. emergency surgery for the treatment of malignant colorectal obstructions: comparison of primary anastomosis and morbidity rates. Dis Colon Rectum. 2002;45:401–406.PubMedCrossRef Martinez-Santos C, Lobato RF, Fradejas JM, Pinto I, Ortega-Deballón P, Moreno-Azcoita M. Self expandable stent before elective surgery vs. emergency surgery for the treatment of malignant colorectal obstructions: comparison of primary anastomosis and morbidity rates. Dis Colon Rectum. 2002;45:401–406.PubMedCrossRef
9.
go back to reference Sebastian S, Johnston S, Geoghegan T, Torreggiani W, Buckley M. Pooled analysis of the efficacy and safety of self-expanding metal stenting in malignant colorectal obstruction. Am J Gastroenterol. 2004;99:2051–2057.PubMedCrossRef Sebastian S, Johnston S, Geoghegan T, Torreggiani W, Buckley M. Pooled analysis of the efficacy and safety of self-expanding metal stenting in malignant colorectal obstruction. Am J Gastroenterol. 2004;99:2051–2057.PubMedCrossRef
10.
go back to reference Meisner S, Hensler M, Knop FK, West F, Wille-Jørgensen P. Self-expanding metal stents for colonic obstruction: experiences from 104 procedures in a single center. Dis Colon Rectum. 2004;47:444–450.PubMedCrossRef Meisner S, Hensler M, Knop FK, West F, Wille-Jørgensen P. Self-expanding metal stents for colonic obstruction: experiences from 104 procedures in a single center. Dis Colon Rectum. 2004;47:444–450.PubMedCrossRef
11.
go back to reference Fan Y-B, Cheng Y-S, Chen N-W, et al. Clinical application of self-expanding metallic stent in the management of acute left-sided colorectal malignant obstruction. World J Gastroenterol. 2006;12:755–759.PubMed Fan Y-B, Cheng Y-S, Chen N-W, et al. Clinical application of self-expanding metallic stent in the management of acute left-sided colorectal malignant obstruction. World J Gastroenterol. 2006;12:755–759.PubMed
12.
go back to reference Li YD, Cheng YS, Li MH, et al. Management of acute malignant colorectal obstruction with a novel self-expanding metallic stent as a bridge to surgery. Eur J Radiol. 2010;73:566–571.PubMedCrossRef Li YD, Cheng YS, Li MH, et al. Management of acute malignant colorectal obstruction with a novel self-expanding metallic stent as a bridge to surgery. Eur J Radiol. 2010;73:566–571.PubMedCrossRef
13.
go back to reference Tekkis PP, Kinsman R, Thompson MR, Stamatakis JD. Association of Coloproctology of Great Britain, Ireland. The Association of Coloproctology of Great Britain and Ireland study of large bowel obstruction caused by colorectal cancer. Ann Surg. 2004;240:76–81.PubMedCrossRef Tekkis PP, Kinsman R, Thompson MR, Stamatakis JD. Association of Coloproctology of Great Britain, Ireland. The Association of Coloproctology of Great Britain and Ireland study of large bowel obstruction caused by colorectal cancer. Ann Surg. 2004;240:76–81.PubMedCrossRef
14.
go back to reference Leong QM, Aung MO, Ho CK, Sim R. Emergency colorectal resections in Asian octogenarians: factors impacting surgical outcome. Surg Today. 2009;39:575–579.PubMedCrossRef Leong QM, Aung MO, Ho CK, Sim R. Emergency colorectal resections in Asian octogenarians: factors impacting surgical outcome. Surg Today. 2009;39:575–579.PubMedCrossRef
15.
go back to reference Harris GJC, Senagore AJ, Lavery IC, Fazio VW. The management of neoplasticcolorectal obstruction with colonic endoluminal stenting devices. Am J Surg. 2001;181:499–506.PubMedCrossRef Harris GJC, Senagore AJ, Lavery IC, Fazio VW. The management of neoplasticcolorectal obstruction with colonic endoluminal stenting devices. Am J Surg. 2001;181:499–506.PubMedCrossRef
16.
go back to reference Khot UP, Wenk Lang A, Murali K, Parker MC. Systematic review of the efficacy and safety of colorectal stents. Br J Surg. 2002;89:1096–1102.PubMedCrossRef Khot UP, Wenk Lang A, Murali K, Parker MC. Systematic review of the efficacy and safety of colorectal stents. Br J Surg. 2002;89:1096–1102.PubMedCrossRef
17.
go back to reference Leitman IM, Sullivan JD, Brams D, DeCosse JJ. Multivariate analysis of morbidity and mortality from the initial surgical management of obstructing carcinoma of the colon. Surg Gynecol Obstet. 1992;174:513–518.PubMed Leitman IM, Sullivan JD, Brams D, DeCosse JJ. Multivariate analysis of morbidity and mortality from the initial surgical management of obstructing carcinoma of the colon. Surg Gynecol Obstet. 1992;174:513–518.PubMed
18.
go back to reference Tilney HS, Lovegrove RE, Purkayastha S, et al. Comparison of colonic stenting, open surgery for malignant large bowel obstruction. Surg Endosc. 2007;21:225–233.PubMedCrossRef Tilney HS, Lovegrove RE, Purkayastha S, et al. Comparison of colonic stenting, open surgery for malignant large bowel obstruction. Surg Endosc. 2007;21:225–233.PubMedCrossRef
19.
go back to reference Carne PW, Frye JN, Robertson GM, Frizelle FA. Stents or open operation for palliation of colorectal cancer: a retrospective, cohort study of perioperative outcome and long-term survival. Dis Colon Rectum. 2004;47:1455–1461.PubMedCrossRef Carne PW, Frye JN, Robertson GM, Frizelle FA. Stents or open operation for palliation of colorectal cancer: a retrospective, cohort study of perioperative outcome and long-term survival. Dis Colon Rectum. 2004;47:1455–1461.PubMedCrossRef
20.
go back to reference Saida Y, Sumiyama Y, Nagao J, Uramatsu M. Long-term prognosis of preoperative bridge to surgery expandable metallic stent insertion for obstructive colorectal cancer comparison with emergency operation. Dis Colon Rectum. 2003;46:S44–S49.PubMed Saida Y, Sumiyama Y, Nagao J, Uramatsu M. Long-term prognosis of preoperative bridge to surgery expandable metallic stent insertion for obstructive colorectal cancer comparison with emergency operation. Dis Colon Rectum. 2003;46:S44–S49.PubMed
Metadata
Title
Comparison of Self-Expanding Metal Stents and Urgent Surgery for Left-Sided Malignant Colonic Obstruction in Elderly Patients
Authors
Ming-gao Guo
Yi Feng
Qi Zheng
Jian-zhong Di
Yu Wang
You-ben Fan
Xin-Yu Huang
Publication date
01-09-2011
Publisher
Springer US
Published in
Digestive Diseases and Sciences / Issue 9/2011
Print ISSN: 0163-2116
Electronic ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-011-1648-4

Other articles of this Issue 9/2011

Digestive Diseases and Sciences 9/2011 Go to the issue