Cancers that invade the brain are universally fatal. The corrosive nature of invasive cancers on the delicate neurologic framework generates harrowing neurologic deficits that can be devastating on quality of life of our cancer patients. Despite significant advances in the diagnosis and management of brain metastases, poor prognoses are inevitable even with when applying the best standard treatment strategies. This sobering fact is an ugly confession that we are still far from winning the battle against cancer metastasis in the central nervous system (CNS). …
Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.