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01-08-2018 | EDITORIAL

Thiamine Therapy for Heart Failure: a Promise or Fiction?

Authors: Ajoe John Kattoor, Akshay Goel, Jawahar L. Mehta

Published in: Cardiovascular Drugs and Therapy | Issue 4/2018

Excerpt

Thiamine (vitamin B1) is an essential water-soluble vitamin required for cellular energy production. Thiamine pyrophosphate (TPP) is a coenzyme in the pentose phosphate pathway for transketolation of glucose-6-phosphate to ribose-5-phosphate. In the Kreb’s cycle, TPP is needed for the functioning of the pyruvate dehydrogenase complex (which converts pyruvate to acetyl CoA) and alpha-ketoglutarate dehydrogenase (which converts alpha-ketoglutarate to succinate). These reactions are needed for aerobic metabolism and production of ATP. Thiamine also helps in the conduction of nerve impulses, independent of its coenzyme functions. It is important for maintenance of nerve membrane stability and modulates membrane ion channels for efficient nerve conduction [1]. …

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Title: Thiamine Therapy for Heart Failure: a Promise or Fiction?
Authors: Ajoe John Kattoor
Akshay Goel
Jawahar L. Mehta
Publication date: 01-08-2018
Publisher: Springer US
Published in: Cardiovascular Drugs and Therapy / Issue 4/2018
Print ISSN: 0920-3206
Electronic ISSN: 1573-7241
DOI: https://doi.org/10.1007/s10557-018-6808-8

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