Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Cancer and Metastasis Reviews
Published in: Cancer and Metastasis Reviews 1/2020

01-03-2020 | Acute Lymphoblastic Leukemia

Bariatric interventions in obesity treatment and prevention in pediatric acute lymphoblastic leukemia: a systematic review and meta-analysis

Authors: Kuan-Wen Wang, Salma Ladhani, Brianna Empringham, Carol Portwine, Adam Fleming, Laura Banfield, Janatani Balakumaran, Lisa Sarpong, E. Danielle Sims, Alexander Nicholas Popa, Lehana Thabane, M. Constantine Samaan

Published in: Cancer and Metastasis Reviews | Issue 1/2020

Login to get access

Abstract

Most children are surviving acute lymphoblastic leukemia (ALL) today. Yet, the emergence of cardiometabolic comorbidities in this population may impact long-term outcomes including the quality of life and lifespan. Obesity is a major driver of cardiometabolic disorders in the general population, and in ALL patients it is associated with increased risk of hypertension, dysglycemia, and febrile neutropenia when compared with lean ALL patients undergoing therapy. This systematic review aims to assess the current evidence for bariatric interventions to manage obesity in children with ALL. The primary outcome for this systematic review was the change in BMI z-score with implementation of the interventions studied. Literature searches were conducted in several databases. Ten publications addressing the study question were included in this review, and five studies were used in the meta-analysis to assess the impact of the bariatric interventions on obesity. The BMI z-score did not change significantly with the interventions. However, the quality of evidence was low, which precluded the recommendation of their use. In conclusion, prospective, rigorous, adequately powered, and high-quality longitudinal studies are urgently needed to deliver effective lifestyle interventions to children with ALL to treat and prevent obesity. These interventions, if successful, may improves cardiometabolic health outcomes and enhance the quality of life and life expectancy in children with ALL.
Appendix
Available only for authorised users
Literature
1.
Hunger, S. P., Lu, X., Devidas, M., Camitta, B. M., Gaynon, P. S., Winick, N. J., Reaman, G. H., & Carroll, W. L. (2012). Improved survival for children and adolescents with acute lymphoblastic leukemia between 1990 and 2005: a report from the children’s oncology group. Journal of Clinical Oncology, 30(14), 1663–1669.CrossRefPubMedPubMedCentral
2.
Hersh, E. M., Bodey, G. P., Nies, B. A., & Freireich, E. J. (1965). Causes of death in acute leukemia: a ten-year study of 414 patients from 1954-1963. JAMA, 193, 105–109.CrossRefPubMed
3.
Slats, A. M., Egeler, R. M., van der Does-van den Berg, A., Korbijn, C., Hahlen, K., Kamps, W. A., Veerman, A. J., & Zwaan, C. M. (2005). Causes of death--other than progressive leukemia--in childhood acute lymphoblastic (ALL) and myeloid leukemia (AML): the Dutch Childhood Oncology Group experience. Leukemia, 19(4), 537–544.CrossRefPubMed
4.
Meenan, C. K., Kelly, J. A., Wang, L., Ritchey, A. K., & Maurer, S. H. (2019). Obesity in pediatric patients with acute lymphoblastic leukemia increases the risk of adverse events during pre-maintenance chemotherapy. Pediatric Blood & Cancer, 66(2), e27515.CrossRef
5.
Fidler, M. M., Reulen, R. C., Henson, K., Kelly, J., Cutter, D., Levitt, G. A., Frobisher, C., Winter, D. L., & Hawkins, M. M. (2017). Population-based long-term cardiac-specific mortality among 34 489 five-year survivors of childhood cancer in Great Britain. Circulation, 135(10), 951–963.CrossRefPubMedPubMedCentral
6.
Gudmundsdottir, T., Winther, J. F., de Fine, L. S., Bonnesen, T. G., Asdahl, P. H., Tryggvadottir, L., Anderson, H., Wesenberg, F., Malila, N., Hasle, H., et al. (2015). Cardiovascular disease in adult life after childhood cancer in Scandinavia: a population-based cohort study of 32,308 one-year survivors. International Journal of Cancer, 137(5), 1176–1186.CrossRefPubMed
7.
Haddy, N., Diallo, S., El-Fayech, C., Schwartz, B., Pein, F., Hawkins, M., Veres, C., Oberlin, O., Guibout, C., Pacquement, H., et al. (2016). Cardiac diseases following childhood cancer treatment: cohort study. Circulation, 133(1), 31–38.CrossRefPubMed
8.
Kourti, M., Tragiannidis, A., Makedou, A., Papageorgiou, T., Rousso, I., & Athanassiadou, F. (2005). Metabolic syndrome in children and adolescents with acute lymphoblastic leukemia after the completion of chemotherapy. Journal of Pediatric Hematology/Oncology, 27(9), 499–501.CrossRefPubMed
9.
Ng, M., Fleming, T., Robinson, M., Thomson, B., Graetz, N., Margono, C., Mullany, E. C., Biryukov, S., Abbafati, C., Abera, S. F., et al. (2014). Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013. The Lancet, 384(9945), 766–781.CrossRef
10.
Oeffinger, K. C., Adams-Huet, B., Victor, R. G., Church, T. S., Snell, P. G., Dunn, A. L., Eshelman-Kent, D. A., Ross, R., Janiszewski, P. M., Turoff, A. J., Brooks, S., & Vega, G. L. (2009). Insulin resistance and risk factors for cardiovascular disease in young adult survivors of childhood acute lymphoblastic leukemia. Journal of Clinical Oncology, 27(22), 3698–3704.CrossRefPubMedPubMedCentral
11.
Oeffinger, K. C., Buchanan, G. R., Eshelman, D. A., Denke, M. A., Andrews, T. C., Germak, J. A., Tomlinson, G. E., Snell, L. E., & Foster, B. M. (2001). Cardiovascular risk factors in young adult survivors of childhood acute lymphoblastic leukemia. Journal of Pediatric Hematology/Oncology, 23(7), 424–430.CrossRefPubMed
12.
Ladhani, S., Empringham, B., Wang, K. W., Portwine, C., Banfield, L., de Souza, R. J., Thabane, L., & Samaan, M. C. (2018). Overweight and obesity management strategies in survivors of paediatric acute lymphoblastic leukaemia: a systematic review protocol. BMJ Open, 8(6), e022530.CrossRefPubMedPubMedCentral
13.
Nguyen, N. T., & Varela, J. E. (2017). Bariatric surgery for obesity and metabolic disorders: state of the art. Nature Reviews. Gastroenterology & Hepatology, 14(3), 160–169.CrossRef
14.
Higgins JPT, Sterne JAC, Savovic J, Page MJ, Hrobjartsson A, Boutron I, Reeves B, Eldridge S: A revised tool for assessing risk of bias in randomized trials. In: Cochrane methods. edn. Edited by Chandler J, McKenzie J, Boutron I, Welch V: Cochrane Database Of Systematic Reviews; 2016, Issue 10 (Suppl 1).
15.
Sterne, J. A., Hernan, M. A., Reeves, B. C., Savovic, J., Berkman, N. D., Viswanathan, M., Henry, D., Altman, D. G., Ansari, M. T., Boutron, I., et al. (2016). ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions. BMJ, 355, i4919.CrossRefPubMedPubMedCentral
16.
Seida, J. C., LeBlanc, C., Schouten, J. R., Mousavi, S. S., Hartling, L., Vandermeer, B., Tjosvold, L., & Sheps, D. M. (2010). Systematic review: nonoperative and operative treatments for rotator cuff tears. Annals of Internal Medicine, 153(4), 246–255.CrossRefPubMed
17.
Atkins, D., Best, D., Briss, P. A., Eccles, M., Falck-Ytter, Y., Flottorp, S., Guyatt, G. H., Harbour, R. T., Haugh, M. C., Henry, D., Hill, S., Jaeschke, R., Leng, G., Liberati, A., Magrini, N., Mason, J., Middleton, P., Mrukowicz, J., O’Connell, D., Oxman, A. D., Phillips, B., Schünemann, H. J., Edejer, T., Varonen, H., Vist, G. E., Williams JW Jr, Zaza, S., & GRADE Working Group. (2004). Grading quality of evidence and strength of recommendations. BMJ, 328(7454), 1490.CrossRefPubMed
18.
Fu, R., Vandermeer, B. W., Shamliyan, T. A., O’Neil, M. E., Yazdi, F., Fox, S. H., & Morton, S. C. (2013). Handling continuous outcomes in quantitative synthesis. In Methods guide for effectiveness and comparative effectiveness reviews. Rockville: Agency for Healthcare Research and Quality (US).
19.
Wan, X., Wang, W., Liu, J., & Tong, T. (2014). Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range. BMC Medical Research Methodology, 14, 135.CrossRefPubMedPubMedCentral
20.
21.
Oosterhoff, M., Joore, M., & Ferreira, I. (2016). The effects of school-based lifestyle interventions on body mass index and blood pressure: a multivariate multilevel meta-analysis of randomized controlled trials. Obesity Reviews, 17(11), 1131–1153.CrossRefPubMed
22.
Zhang, F. F., Liu, S., Chung, M., & Kelly, M. J. (2015). Growth patterns during and after treatment in patients with pediatric ALL: a meta-analysis. Pediatric Blood & Cancer, 62(8), 1452–1460.CrossRef
23.
24.
Hartman, A., te Winkel, M. L., van Beek, R. D., de Muinck Keizer-Schrama, S. M., Kemper, H. C., Hop, W. C., van den Heuvel-Eibrink, M. M., & Pieters, R. (2009). A randomized trial investigating an exercise program to prevent reduction of bone mineral density and impairment of motor performance during treatment for childhood acute lymphoblastic leukemia. Pediatric Blood & Cancer, 53(1), 64–71.CrossRef
25.
Huang, J. S., Dillon, L., Terrones, L., Schubert, L., Roberts, W., Finklestein, J., Swartz, M. C., Norman, G. J., & Patrick, K. (2014). Fit4Life: a weight loss intervention for children who have survived childhood leukemia. Pediatric Blood & Cancer, 61(5), 894–900.CrossRef
26.
Li, R., Donnella, H., Knouse, P., Raber, M., Crawford, K., Swartz, M. C., Wu, J., Liu, D., & Chandra, J. (2017). A randomized nutrition counseling intervention in pediatric leukemia patients receiving steroids results in reduced caloric intake. Pediatric Blood & Cancer, 64(2), 374–380.CrossRef
27.
Moyer-Mileur, L. J., Ransdell, L., & Bruggers, C. S. (2009). Fitness of children with standard-risk acute lymphoblastic leukemia during maintenance therapy: response to a home-based exercise and nutrition program. Journal of Pediatric Hematology/Oncology, 31(4), 259–266.CrossRefPubMed
28.
Esbenshade, A. J., Friedman, D. L., Smith, W. A., Jeha, S., Pui, C. H., Robison, L. L., & Ness, K. K. (2014). Feasibility and initial effectiveness of home exercise during maintenance therapy for childhood acute lymphoblastic leukemia. Pediatric Physical Therapy, 26(3), 301–307.CrossRefPubMedPubMedCentral
29.
Jarvela, L. S., Kemppainen, J., Niinikoski, H., Hannukainen, J. C., Lahteenmaki, P. M., Kapanen, J., Arola, M., & Heinonen, O. J. (2012). Effects of a home-based exercise program on metabolic risk factors and fitness in long-term survivors of childhood acute lymphoblastic leukemia. Pediatric Blood & Cancer, 59(1), 155–160.CrossRef
30.
San Juan, A. F., Fleck, S. J., Chamorro-Vina, C., Mate-Munoz, J. L., Moral, S., Perez, M., Cardona, C., Del Valle, M. F., Hernandez, M., Ramirez, M., et al. (2007). Effects of an intrahospital exercise program intervention for children with leukemia. Medicine and Science in Sports and Exercise, 39(1), 13–21.CrossRefPubMed
31.
Takken, T., van der Torre, P., Zwerink, M., Hulzebos, E. H., Bierings, M., Helders, P. J., & van der Net, J. (2009). Development, feasibility and efficacy of a community-based exercise training program in pediatric cancer survivors. Psychooncology, 18(4), 440–448.CrossRefPubMed
32.
Wright, M. J., Collins, L., Christie, A., Birken, K., Dettmer, E., & Nathan, P. C. (2013). A comprehensive healthy lifestyle program for children receiving treatment for acute lymphoblastic leukemia: feasibility and preliminary efficacy data. Rehabilitation Oncology, 31(3), 6–13.CrossRef
33.
Hill, R., Hamby, T., Bashore, L., Rapisand, S., Galipp, K., Heym, K., & Bowman, W. P. (2018). Early nutrition intervention attenuates weight gain for pediatric acute lymphoblastic leukemia patients in maintenance therapy. Journal of Pediatric Hematology/Oncology, 40(2), 104–110.CrossRefPubMed
34.
Pandita, A., Sharma, D., Pandita, D., Pawar, S., Tariq, M., & Kaul, A. (2016). Childhood obesity: prevention is better than cure. Diabetes Metabolic Syndrome and Obesity, 9, 83–89.CrossRef
35.
Zhang, F. F., & Parsons, S. K. (2015). Obesity in childhood cancer survivors: call for early weight management. Advances in Nutrition, 6(5), 611–619.CrossRefPubMedPubMedCentral
36.
Hossain, M. J., Xie, L., & McCahan, S. M. (2014). Characterization of pediatric acute lymphoblastic leukemia survival patterns by age at diagnosis. Journal of Cancer Epidemiology, 2014, 865979.CrossRefPubMedPubMedCentral
37.
Miller, K. D., Siegel, R. L., Lin, C. C., Mariotto, A. B., Kramer, J. L., Rowland, J. H., Stein, K. D., Alteri, R., & Jemal, A. (2016). Cancer treatment and survivorship statistics, 2016. CA: a Cancer Journal for Clinicians, 66(4), 271–289.
38.
Siegel, R. L., Miller, K. D., & Jemal, A. (2018). Cancer statistics, 2018. CA: a Cancer Journal for Clinicians, 68(1), 7–30.
39.
Browne, E. K., Zhou, Y., Chemaitilly, W., Panetta, J. C., Ness, K. K., Kaste, S. C., Cheng, C., Relling, M. V., Pui, C. H., & Inaba, H. (2018). Changes in body mass index, height, and weight in children during and after therapy for acute lymphoblastic leukemia. Cancer, 124(21), 4248–4259.CrossRefPubMed
40.
Fulbright, J. M., Raman, S., McClellan, W. S., & August, K. J. (2011). Late effects of childhood leukemia therapy. Current Hematologic Malignancy Reports, 6(3), 195–205.CrossRefPubMed
41.
Geenen, M. M., Cardous-Ubbink, M. C., Kremer, L. C., van den Bos, C., van der Pal, H. J., Heinen, R. C., Jaspers, M. W., Koning, C. C., Oldenburger, F., Langeveld, N. E., Hart, A. A., Bakker, P. J., Caron, H. N., & van Leeuwen, F. (2007). Medical assessment of adverse health outcomes in long-term survivors of childhood cancer. JAMA, 297(24), 2705–2715.CrossRefPubMed
42.
Kızılocak, H., & Okcu, F. (2019). Late effects of therapy in childhood acute lymphoblastic leukemia survivors. Turkish Journal of Haematology, 36(1), 1–11.CrossRefPubMedPubMedCentral
43.
Mody, R., Li, S., Dover, D. C., Sallan, S., Leisenring, W., Oeffinger, K. C., Yasui, Y., Robison, L. L., & Neglia, J. P. (2008). Twenty-five-year follow-up among survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study. Blood, 111(12), 5515–5523.CrossRefPubMedPubMedCentral
44.
Howell, C. R., Wilson, C. L., Ehrhardt, M. J., Partin, R. E., Kaste, S. C., Lanctot, J. Q., Pui, C. H., Robison, L. L., Hudson, M. M., & Ness, K. K. (2018). Clinical impact of sedentary behaviors in adult survivors of acute lymphoblastic leukemia: a report from the St. Jude Lifetime Cohort study. Cancer, 124(5), 1036–1043.CrossRefPubMed
45.
Ladas, E. J., Orjuela, M., Stevenson, K., Cole, P. D., Lin, M., Athale, U. H., Clavell, L. A., Leclerc, J. M., Michon, B., Schorin, M. A., et al. (2016). Dietary intake and childhood leukemia: the Diet and Acute Lymphoblastic Leukemia Treatment (DALLT) cohort study. Nutrition, 32(10), 1103–1109.e1101.CrossRefPubMedPubMedCentral
46.
Gordijn, M. S., van Litsenburg, R. R., Gemke, R. J., Huisman, J., Bierings, M. B., Hoogerbrugge, P. M., & Kaspers, G. J. (2013). Sleep, fatigue, depression, and quality of life in survivors of childhood acute lymphoblastic leukemia. Pediatric Blood & Cancer, 60(3), 479–485.CrossRef
47.
Hartman, A., Hop, W., Takken, T., Pieters, R., & van den Heuvel-Eibrink, M. (2013). Motor performance and functional exercise capacity in survivors of pediatric acute lymphoblastic leukemia. Pediatric Blood & Cancer, 60(3), 494–499.CrossRef
48.
Ness, K. K., Kaste, S. C., Zhu, L., Pui, C. H., Jeha, S., Nathan, P. C., Inaba, H., Wasilewski-Masker, K., Shah, D., Wells, R. J., Karlage, R. E., Robison, L. L., & Cox, C. L. (2015). Skeletal, neuromuscular and fitness impairments among children with newly diagnosed acute lymphoblastic leukemia. Leukemia & Lymphoma, 56(4), 1004–1011.CrossRef
49.
San Juan, A. F., Chamorro-Vina, C., Mate-Munoz, J. L., Fernandez del Valle, M., Cardona, C., Hernandez, M., Madero, L., Perez, M., Ramirez, M., & Lucia, A. (2008). Functional capacity of children with leukemia. International Journal of Sports Medicine, 29(2), 163–167.CrossRefPubMed
50.
Varedi, M., McKenna, R., & Lamberg, E. M. (2017). Balance in children with acute lymphoblastic leukemia. Pediatrics International, 59(3), 293–302.CrossRefPubMed
51.
Arpe, M. L., Rorvig, S., Kok, K., Molgaard, C., & Frandsen, T. L. (2015). The association between glucocorticoid therapy and BMI z-score changes in children with acute lymphoblastic leukemia. Support Care Cancer, 23(12), 3573–3580.CrossRefPubMed
52.
Ness, K. K., Armenian, S. H., Kadan-Lottick, N., & Gurney, J. G. (2011). Adverse effects of treatment in childhood acute lymphoblastic leukemia: general overview and implications for long-term cardiac health. Expert Review of Hematology, 4(2), 185–197.CrossRefPubMedPubMedCentral
53.
Reilly, J. J., Brougham, M., Montgomery, C., Richardson, F., Kelly, A., & Gibson, B. E. (2001). Effect of glucocorticoid therapy on energy intake in children treated for acute lymphoblastic leukemia. The Journal of Clinical Endocrinology and Metabolism, 86(8), 3742–3745.CrossRefPubMed
54.
Winkler, M. R., Hockenberry, M. J., McCarthy, K. S., & Silva, S. G. (2015). Trajectories of obesity and overweight rates among survivors of childhood acute lymphoblastic leukemia. Oncology Nursing Forum, 42(4), E287–E293.CrossRefPubMed
55.
Zhang, F. F., Rodday, A. M., Kelly, M. J., Must, A., MacPherson, C., Roberts, S. B., Saltzman, E., & Parsons, S. K. (2014). Predictors of being overweight or obese in survivors of pediatric acute lymphoblastic leukemia (ALL). Pediatric Blood & Cancer, 61(7), 1263–1269.CrossRef
56.
Brown, A. L., Lupo, P. J., Danysh, H. E., Okcu, M. F., Scheurer, M. E., & Kamdar, K. Y. (2016). Prevalence and predictors of overweight and obesity among a multiethnic population of pediatric acute lymphoblastic leukemia survivors: a cross-sectional assessment. Journal of Pediatric Hematology/Oncology, 38(6), 429–436.CrossRefPubMedPubMedCentral
57.
Withycombe, J. S., Post-White, J. E., Meza, J. L., Hawks, R. G., Smith, L. M., Sacks, N., & Seibel, N. L. (2009). Weight patterns in children with higher risk ALL: a report from the Children’s Oncology Group (COG) for CCG 1961. Pediatric Blood & Cancer, 53(7), 1249–1254.CrossRef
58.
Butturini, A. M., Dorey, F. J., Lange, B. J., Henry, D. W., Gaynon, P. S., Fu, C., Franklin, J., Siegel, S. E., Seibel, N. L., Rogers, P. C., Sather, H., Trigg, M., Bleyer, W. A., & Carroll, W. L. (2007). Obesity and outcome in pediatric acute lymphoblastic leukemia. Journal of Clinical Oncology, 25(15), 2063–2069.CrossRefPubMed
59.
Gelelete, C. B., Pereira, S. H., Azevedo, A. M., Thiago, L. S., Mundim, M., Land, M. G., & Costa, E. S. (2011). Overweight as a prognostic factor in children with acute lymphoblastic leukemia. Obesity (Silver Spring), 19(9), 1908–1911.CrossRef
60.
Orgel, E., Sposto, R., Malvar, J., Seibel, N. L., Ladas, E., Gaynon, P. S., & Freyer, D. R. (2014). Impact on survival and toxicity by duration of weight extremes during treatment for pediatric acute lymphoblastic leukemia: a report from the Children’s Oncology Group. Journal of Clinical Oncology, 32(13), 1331–1337.CrossRefPubMedPubMedCentral
61.
Haliloglu, B., & Bereket, A. (2015). Hypothalamic obesity in children: pathophysiology to clinical management. Journal of Pediatric Endocrinology & Metabolism, 28(5–6), 503–513.
62.
Lustig, R. H. (2011). Hypothalamic obesity after craniopharyngioma: mechanisms, diagnosis, and treatment. Frontiers in Endocrinology (Lausanne), 2, 60.
63.
Muller, H. L. (2016). Craniopharyngioma and hypothalamic injury: latest insights into consequent eating disorders and obesity. Current Opinion in Endocrinology, Diabetes, and Obesity, 23(1), 81–89.CrossRefPubMed
64.
Kolsgaard, M. L., Joner, G., Brunborg, C., Anderssen, S. A., Tonstad, S., & Andersen, L. F. (2011). Reduction in BMI z-score and improvement in cardiometabolic risk factors in obese children and adolescents. The Oslo Adiposity Intervention Study - a hospital/public health nurse combined treatment. BMC Pediatrics, 11, 47.CrossRefPubMedPubMedCentral
65.
Masquio, D. C., de Piano, A., Sanches, P. L., Corgosinho, F. C., Campos, R. M., Carnier, J., da Silva, P. L., Caranti, D. A., Tock, L., Oyama, L. M., Oller do Nascimento, C. M., de Mello, M. T., Tufik, S., & Dâmaso, A. R. (2013). The effect of weight loss magnitude on pro-/anti-inflammatory adipokines and carotid intima-media thickness in obese adolescents engaged in interdisciplinary weight loss therapy. Clinical Endocrinology, 79(1), 55–64.CrossRefPubMed
66.
Jung, J. H., Jung, M. K., Kim, K. E., Kwon, A. R., Chae, H. W., Yoon, C. S., Kim, H. S., & Kim, D.-H. (2016). Ultrasound measurement of pediatric visceral fat thickness: correlations with metabolic and liver profiles. Annals of Pediatric Endocrinology and Metabolism, 21(2), 75–80.CrossRefPubMedPubMedCentral
67.
Taylor, R. W., Jones, I. E., Williams, S. M., & Goulding, A. (2000). Evaluation of waist circumference, waist-to-hip ratio, and the conicity index as screening tools for high trunk fat mass, as measured by dual-energy X-ray absorptiometry, in children aged 3–19 y. The American Journal of Clinical Nutrition, 72(2), 490–495.CrossRefPubMed
Metadata
Title
Bariatric interventions in obesity treatment and prevention in pediatric acute lymphoblastic leukemia: a systematic review and meta-analysis
Authors
Kuan-Wen Wang
Salma Ladhani
Brianna Empringham
Carol Portwine
Adam Fleming
Laura Banfield
Janatani Balakumaran
Lisa Sarpong
E. Danielle Sims
Alexander Nicholas Popa
Lehana Thabane
M. Constantine Samaan
Publication date
01-03-2020
Publisher
Springer US
Published in
Cancer and Metastasis Reviews / Issue 1/2020
Print ISSN: 0167-7659
Electronic ISSN: 1573-7233
DOI
https://doi.org/10.1007/s10555-020-09849-y

Other articles of this Issue 1/2020

Cancer and Metastasis Reviews 1/2020 Go to the issue

ReviewPaper

What recent primary studies tell us about ovarian teratomas in children: a scoping review

ReviewPaper

Insights into the prenatal origin of childhood acute lymphoblastic leukemia

ReviewPaper

What are the effects of exercise training in childhood cancer survivors? A systematic review

ReviewPaper

A systematic approach to the endocrine care of survivors of pediatric hematopoietic stem cell transplantation

Correction

Correction to: Neurological complications of pediatric cancer

ReviewPaper

Drug repurposing towards targeting cancer stem cells in pediatric brain tumors
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Watch now

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine
Image Credits