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01-12-2018 | NON-THEMATIC REVIEW

Cross-talk between lung cancer and bones results in neutrophils that promote tumor progression

Authors: Patrick O. Azevedo, Ana E. Paiva, Gabryella S. P. Santos, Luiza Lousado, Julia P. Andreotti, Isadora F. G. Sena, Carlos A. Tagliati, Akiva Mintz, Alexander Birbrair

Published in: Cancer and Metastasis Reviews | Issue 4/2018

Abstract

Lung cancer is the leading cause of cancer mortality around the world. The lack of detailed understanding of the cellular and molecular mechanisms participating in the lung tumor progression restrains the development of efficient treatments. Recently, by using state-of-the-art technologies, including in vivo sophisticated Cre/loxP technologies in combination with lung tumor models, it was revealed that osteoblasts activate neutrophils that promote tumor growth in the lung. Strikingly, genetic ablation of osteoblasts abolished lung tumor progression via interruption of SiglecF^high–expressing neutrophils supply to the tumor microenvironment. Interestingly, SiglecF^high neutrophil signature was associated with worse lung adenocarcinoma patients outcome. This study identifies novel cellular targets for lung cancer treatment. Here, we summarize and evaluate recent advances in our understanding of lung tumor microenvironment.

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Title: Cross-talk between lung cancer and bones results in neutrophils that promote tumor progression
Authors: Patrick O. Azevedo
Ana E. Paiva
Gabryella S. P. Santos
Luiza Lousado
Julia P. Andreotti
Isadora F. G. Sena
Carlos A. Tagliati
Akiva Mintz
Alexander Birbrair
Publication date: 01-12-2018
Publisher: Springer US
Published in: Cancer and Metastasis Reviews / Issue 4/2018
Print ISSN: 0167-7659
Electronic ISSN: 1573-7233
DOI: https://doi.org/10.1007/s10555-018-9759-4

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