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01-11-2018 | Review Paper

Targeting glioblastoma-derived pericytes improves chemotherapeutic outcome

Authors: Daniel A. P. Guerra, Ana E. Paiva, Isadora F. G. Sena, Patrick O. Azevedo, Walison N. Silva, Akiva Mintz, Alexander Birbrair

Published in: Angiogenesis | Issue 4/2018

Abstract

Glioblastoma is the most common malignant brain cancer in adults, with poor prognosis. The blood–brain barrier limits the arrival of several promising anti-glioblastoma drugs, and restricts the design of efficient therapies. Recently, by using state-of-the-art technologies, including thymidine kinase targeting system in combination with glioblastoma xenograft mouse models, it was revealed that targeting glioblastoma-derived pericytes improves chemotherapy efficiency. Strikingly, ibrutinib treatment enhances chemotherapeutic effectiveness, by targeting pericytes, improving blood–brain barrier permeability, and prolonging survival. This study identifies glioblastoma-derived pericyte as a novel target in the brain tumor microenvironment during carcinogenesis. Here, we summarize and evaluate recent advances in the understanding of pericyte’s role in the glioblastoma microenvironment.

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Title: Targeting glioblastoma-derived pericytes improves chemotherapeutic outcome
Authors: Daniel A. P. Guerra
Ana E. Paiva
Isadora F. G. Sena
Patrick O. Azevedo
Walison N. Silva
Akiva Mintz
Alexander Birbrair
Publication date: 01-11-2018
Publisher: Springer Netherlands
Published in: Angiogenesis / Issue 4/2018
Print ISSN: 0969-6970
Electronic ISSN: 1573-7209
DOI: https://doi.org/10.1007/s10456-018-9621-x

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