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Published in: Cancer and Metastasis Reviews 2-3/2018

01-09-2018

Targeting lipid mediators in cancer biology

Authors: Megan L. Sulciner, Allison Gartung, Molly M. Gilligan, Charles N. Serhan, Dipak Panigrahy

Published in: Cancer and Metastasis Reviews | Issue 2-3/2018

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Abstract

Bioactive lipids are essential components of human cells and tissues. As discussed in this review, the cancer lipidome is diverse and malleable, with the ability to promote or inhibit cancer pathogenesis. Targeting lipids within the tumor and surrounding microenvironment may be a novel therapeutic approach for treating cancer patients. Additionally, the emergence of a novel super-family of lipid mediators termed specialized pro-resolving mediators (SPMs) has revealed a new role for bioactive lipid mediators in the resolution of inflammation in cancer biology. The role of SPMs in cancer holds great promise in our understanding of cancer pathogenesis and can ultimately be used in future cancer diagnostics and therapy.
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Metadata
Title
Targeting lipid mediators in cancer biology
Authors
Megan L. Sulciner
Allison Gartung
Molly M. Gilligan
Charles N. Serhan
Dipak Panigrahy
Publication date
01-09-2018
Publisher
Springer US
Published in
Cancer and Metastasis Reviews / Issue 2-3/2018
Print ISSN: 0167-7659
Electronic ISSN: 1573-7233
DOI
https://doi.org/10.1007/s10555-018-9754-9

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