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Cancer and Metastasis Reviews
Published in: Cancer and Metastasis Reviews 3/2017

01-09-2017

Alcohol and head and neck cancer

Authors: Daisuke Kawakita, Keitaro Matsuo

Published in: Cancer and Metastasis Reviews | Issue 3/2017

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Abstract

In this article, we reviewed the association between alcohol drinking and head and neck cancer (HNC) and its subsites, using the available literature. Alcohol drinking is an established risk factor for HNC, and this association may be stronger among cancers of the oropharynx and hypopharynx than the oral cavity or larynx. In addition, higher alcohol consumption over a shorter period was more harmful than fewer alcohol consumption over a longer period, and the most frequently consumed alcoholic beverages in a population is likely to be associated with the highest risk of HNC in that population. The risk of HNC after ≥ 20 years of alcohol cessation appear to be similar to the risk among never drinkers. The interaction between genetic polymorphisms related to alcohol metabolism and alcohol drinking on the risk of HNC has been noted, and the prevalence of these genetic polymorphisms in each population should be of concern. Finally, the association between alcohol drinking and the survival of individuals with HNC remains unclear, and mortality due to competing causes should be considered in future research to evaluate this association.
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Metadata
Title
Alcohol and head and neck cancer
Authors
Daisuke Kawakita
Keitaro Matsuo
Publication date
01-09-2017
Publisher
Springer US
Published in
Cancer and Metastasis Reviews / Issue 3/2017
Print ISSN: 0167-7659
Electronic ISSN: 1573-7233
DOI
https://doi.org/10.1007/s10555-017-9690-0

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