Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
BMC Cancer
Published in: BMC Cancer 1/2010

Open Access 01-12-2010 | Research article

The PstI/RsaI and DraI polymorphisms of CYP2E1and head and neck cancer risk: a meta-analysis based on 21 case-control studies

Authors: Kefu Tang, Yang Li, Zhao Zhang, Yunmin Gu, Yuyu Xiong, Guoyin Feng, Lin He, Shengying Qin

Published in: BMC Cancer | Issue 1/2010

Login to get access

Abstract

Background

CYP2E1 encodes a member of the cytochrome P450 superfamily of enzymes which play a central role in activating and detoxifying many carcinogens and endogenous compounds thought to be involved in the development of cancer. The PstI/RsaI and DraI polymorphism are two of the most commonly studied polymorphisms of the gene for their association with risk of head and neck cancer, but the results are conflicting.

Methods

We performed a meta-analysis using 21 eligible case-control studies with a total of 4,951 patients and 6,071 controls to summarize the data on the association between the CYP2E1 PstI/RsaI and DraI polymorphism and head and neck cancer risk, especially by interacting with smoking or alcohol.

Results

Compared with the wild genotype, the OR was 1.96 (95% CI: 1.33-2.90) for PstI/RsaI and 1.56 (95% CI: 1.06-2.27) for DraI polymorphism respectively. When stratified according to ethnicity, the OR increased in the Asians for both polymorphisms (OR = 2.04, 95% CI: 1.32-3.15 for PstI/RsaI; OR = 2.04, 95% CI: 1.27-3.29 for DraI), suggesting that the risk is more pronounced in Asians.

Conclusion

Our meta-analysis suggests that individuals with the homozygote genotypes of PstI/RsaI or DraI polymorphism might be associated with an increased risk of head and neck cancer, especially in Asians.
Appendix
Available only for authorised users
Literature
1.
Hunter KD, Parkinson EK, Harrison PR: Profiling early head and neck cancer. Nat Rev Cancer. 2005, 5: 127-135. 10.1038/nrc1549.CrossRefPubMed
2.
Olivieri EH, da Silva SD, Mendonça FF, Urata YN, Vidal DO, Faria MD, Nishimoto IN, Rainho CA, Kowalski LP, Rogatto SR: CYP1A2*1C, CYP2E1*5B, and GSTM1 polymorphisms are predictors of risk and poor outcome in head and neck squamous cell carcinoma patients. Oral Oncol. 2009, 45: e73-e79. 10.1016/j.oraloncology.2009.03.004.CrossRefPubMed
3.
Ruwali M, Khan AJ, Shah PP, Singh AP, Pant MC, Parmar D: Cytochrome P450 2E1and Head and Neck Cancer: Interaction with Genetic and Environmental Risk Factors. Environmental and Molecular Mutagenesis. 2009, 50: 473-482. 10.1002/em.20488.CrossRefPubMed
4.
Guengerich FP, Kim DH, Iwasaki M: Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects. Chem Res Toxicol. 1991, 4: 168-179. 10.1021/tx00020a008.CrossRefPubMed
5.
Ingelman-Sundberg M, Johansson I, Yin H, Terelius Y, Eliasson E, Clot P, Albano E: Ethanol-inducible cytochrome P4502E1: Genetic polymorphism, regulation, and possible role in the etiology of alcohol-induced liver disease. Alcohol. 1993, 10: 447-452. 10.1016/0741-8329(93)90063-T.CrossRefPubMed
6.
Hayashi S, Watanabe J, Kawajiri K: Genetic polymorphisms in the 5'-flanking region change transcriptional regulation of the human cytochrome P450IIE1 gene. J. Biochem. 1991, 110: 559-565.PubMed
7.
Bouchardy C, Hirvonen A, Coutelle C, Ward PJ, Dayer P, Benhamou S: Role of alcohol dehydrogenase 3 and cytochrome P-4502E1 genotypes in susceptibility to cancers of the upper aerodigestive tract. Int J Cancer. 2000, 87: 734-740. 10.1002/1097-0215(20000901)87:5<734::AID-IJC17>3.0.CO;2-E.CrossRefPubMed
8.
Le Marchand L, Sivaraman L, Pierce L, Seifried A, Lum A, Wilkens LR, Lau AF: Associations of CYP1A1, GSTM1,and CYP2E1 polymorphisms with lung cancer suggest cell type specificities to tobacco carcinogens. Cancer Res. 1998, 58: 4858-4863.PubMed
9.
Uematsu F, Ikawa S, Kikuchi S, Sagami I, Kanamaru R, Abe T, Satoh K, Motomiya M, Watanabe M: Restriction fragment length polymorphism of the human CYP2E1 (cytochrome P450IIE1) gene and susceptibility to lung cancer: Possible relevance to low smoking exposure. Pharmacogenetics. 1994, 4: 58-63. 10.1097/00008571-199404000-00002.CrossRefPubMed
10.
Li D, L He: Further clarification of the contribution of the tryptophan hydroxylase (TPH) gene to suicidal behavior using systematic allelic and genotypic meta-analyses. Hum Genet. 2006, 119: 233-240. 10.1007/s00439-005-0113-x.CrossRefPubMed
11.
Cochran WG: The combination of estimates from different experiments. Biometrics. 1954, 10: 101-129. 10.2307/3001666.CrossRef
12.
Colditz GA, Burdick E, Mosteller F: Heterogeneity in meta-analysis of data from epidemiologic studies: A commentary. Am J Epidemiol. 1995, 142 (4): 371-382.PubMed
13.
14.
DerSimonian R, Laird N: Meta-analysis in clinical trials. Control Clin Trials. 1986, 7: 177-188. 10.1016/0197-2456(86)90046-2.CrossRefPubMed
15.
Mantel N, Haenszel W: Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959, 22: 719-748.PubMed
16.
Woolf B: On estimating the relation between blood group and disease. Ann Hum Genet. 1955, 19: 251-253. 10.1111/j.1469-1809.1955.tb01348.x.CrossRefPubMed
17.
18.
Jahnke V, Strange R, Matthias C, Fryer A: Glutathione S-transferase and cytochrome P450 genotypes as risk factors for laryngeal carcinoma. Eur Arch Otorhinolaryngol. 1997, 254 (suppl. 1): S147-S149. 10.1007/BF02439747.CrossRefPubMed
19.
Duarte EC, Ribeiro DC, Gomez MV, Ramos-Jorge ML, Gomez RS: Genetic Polymorphisms of Carcinogen Metabolizing Enzymes are Associated with Oral Leukoplakia Development and p53 Overexpression. Anticancer Research. 2008, 28: 1101-1106.PubMed
20.
Sikdar N, Mahmud SA, Paul RR, Roy B: Polymorphism in CYP1A1 and CYP2E1 genes and susceptibility to leukoplakia in Indian tobacco users. Cancer Letters. 2003, 195: 33-42. 10.1016/S0304-3835(03)00156-3.CrossRefPubMed
21.
Lucas D, Menez C, Floch F, Gourlaouen Y, Sparfel O, Joannet I: Cytochromes P4502E1 and P4501A1 genotypes and susceptibility to cirrhosis or upper aerodigestive tract cancer in alcoholic Caucasians. Alcohol Clin Exp Res. 1996, 20: 1033-1037. 10.1111/j.1530-0277.1996.tb01943.x.CrossRefPubMed
22.
Hildesheim A, Anderson LM, Chen CJ: CYP2E1 genetic polymorphisms and risk of nasopharyngeal carcinoma in Taiwan. J Natl Cancer Inst. 1997, 89: 1207-1212. 10.1093/jnci/89.16.1207.CrossRefPubMed
23.
Hung HC, Chuang J, Chien YC, Chern HD, Chiang CP, Kuo YS: Genetic polymorphisms of CYP2E1, GSTM1, and GSTM3; environmental factors and risk of oral cancer. Cancer Epidemiol Biomarkers Prev. 1997, 6: 901-905.PubMed
24.
González MV, Alvarez V, Pello MF, Menéndez MJ, Suárez C, Coto E: Genetic polymorphism of N-acetyltransferase-2, glutathione S-transferase-M1, and cytochromes P450IIE1 and P450IID6 in the susceptibility to head and neck cancer. Journal of Clinical Pathology. 1998, 51 (4): 294-298. 10.1136/jcp.51.4.294.CrossRefPubMedPubMedCentral
25.
Matthias C, Bockmühl U, Jahnke V, Jones PW, Hayes JD, Alldersea J, Gilford J, Bailey L, Bath J, Worrall SF, Hand P, Fryer AA, Strange RC: Polymorphism in cytochrome P450 CYP2D6, CYP1A1, CYP2E1 and glutathione S-transferase, GSTM1, GSTM3, GSTT1 and susceptibility to tobacco-related cancers: studies in upper aerodigestive tract cancers. Pharmacogenetics. 1998, 8 (2): 91-100. 10.1097/00008571-199804000-00001.CrossRefPubMed
26.
Morita S, Yano M, Tsujinaka T, Akiyama Y, Taniguchi M, Kaneko K, Miki H, Fujii T, Yoshino K, Kusuoka H, Monden M: Genetic Polymorphisms of Drug-Metabolizing Enzymes and Susceptibility to Head-and-Neck Squamous-Cell Carcinoma. Int J Cancer. 1999, 80: 685-688. 10.1002/(SICI)1097-0215(19990301)80:5<685::AID-IJC9>3.0.CO;2-W.CrossRefPubMed
27.
Katoh T, Kaneko S, Kohshi K, Munaka M, Kitagawa K, Kunugita N, Ikemura K, Kawamoto T: Genetic polymorphisms of tobacco- and alcohol-related metabolizing enzymes and oral cavity cancer. Int J Cancer. 1999, 83: 606-609. 10.1002/(SICI)1097-0215(19991126)83:5<606::AID-IJC6>3.0.CO;2-P.CrossRefPubMed
28.
Kongruttanachok N, Sukdikul S, Setavarin S: Cytochrome P450 2E1 polymorphism and nasopharyngeal carcinoma development in Thailand: a correlative study. BMC Cancer. 2001, 1: 4-10.1186/1471-2407-1-4.CrossRefPubMedPubMedCentral
29.
Liu S, Park JY, Schantz SP, Stern JC, Lazarus P: Elucidation of CYP2E1 5' regulatory RsaI/Pstl allelic variants and their role in risk for oral cancer. Oral Oncol. 2001, 37: 437-445. 10.1016/S1368-8375(00)00099-3.CrossRefPubMedPubMedCentral
30.
Neuhaus T, Ko YD, Lorenzen K, Fronhoffs S, Harth V, Bröde P, Vetter H, Bolt HM, Pesch B, Brüning T: Association of cytochrome P450 2E1 Polymorphisms and head and neck squamous cell cancer. Toxicol Lett. 2004, 151: 273-282. 10.1016/j.toxlet.2003.09.017.CrossRefPubMed
31.
Li G, Liu Z, Sturgis EM, Chamberlain RM, Spitz MR, Wei Q: CYP2E1 G1532C, NQO1 Pro187Ser, and CYP1B1 Val432Leu polymorphisms are not associated with risk of squamous cell carcinoma of the head and neck. Cancer Epidemiol Biomarkers Prev. 2005, 14: 1034-1036. 10.1158/1055-9965.EPI-04-0814.CrossRefPubMed
32.
Gajecka M, Rydzanicz M, Jaskula-Sztul R, Kujawski M, Szyfter W, Szyfter K: CYP1A1, CYP2D6, CYP2E1, NAT2, GSTM1 and GSTT1 polymorphisms or their combinations are associated with the increased risk of the laryngeal squamous cell carcinoma. Mutat Res. 2005, 574: 112-123.CrossRefPubMed
33.
Sugimura T, Kumimoto H, Tohnai I, Fukui T, Matsuo K, Tsurusako S: Gene-environment interaction involved in oral carcinogenesis: molecular epidemiological study for metabolic and DNA repair gene polymorphisms. J Oral Pathol Med. 2006, 35: 11-18. 10.1111/j.1600-0714.2005.00364.x.CrossRefPubMed
34.
Gattá GJF, de Carvalho MB, Siraque MS: Genetic polymorphisms of CYP1A1, CYP2E1, GSTM1, and GSTT1 associated with head and neck cancer. Head & Neck. 2006, 28 (9): 819-826.CrossRef
35.
Marques CFS, Koifman S, Koifman RJ, Boffetta P, Brennan P, Hatagima A: Influence of CYP1A1, CYP2E1, GSTM3 and NAT2 genetic polymorphisms in oral cancer susceptibility: results from a case-control study in Rio de Janeiro. Oral Oncology. 2006, 42 (6): 632-637. 10.1016/j.oraloncology.2005.11.003.CrossRefPubMed
36.
Soya SS, Vinod T, Reddy KS, Gopalakrishnan S, Adithan C: CYP2E1 polymorphisms and gene-environment interactions in the risk of upper aerodigestive tract cancers among Indians. Pharmacogenomics. 2008, 9: 551-560. 10.2217/14622416.9.5.551.CrossRefPubMed
37.
Buch Shama C, Nazar-Stewart Valle, Joel L, Weissfeld MarjorieRomkes: Case-control study of oral and oropharyngeal cancer in whites and genetic variation in eight metabolic enzymes. Head & neck. 2008, 30: 1139-1147.CrossRef
38.
Boccia S, Cadoni G, Sayed-Tabatabaei FA, Volante M, Arzani D, De Lauretis A, Cattel C, Almadori G, van Duijn CM, Paludetti G, Ricciardi G: CYP1A1, CYP2E1, GSTM1, GSTT1, EPHX1 exons 3 and 4, and NAT2 polymorphisms, smoking, consumption of alcohol and fruit and vegetables and risk of head and neck cancer. J Cancer Res Clin Oncol. 2008, 134: 93-100. 10.1007/s00432-007-0254-5.CrossRefPubMed
39.
Garte S, Gaspari L, Alexandrie AK: Metabolic gene polymorphism frequencies in control populations. Cancer Epidemiol Biomarkers Prev. 2001, 10: 1239-1248.PubMed
40.
Hirschhorn JN, Lohmueller K, Byrne E, Hirschhorn K: A comprehensive review of genetic association studies. Genet. 2002, 4: 45-61.
Metadata
Title
The PstI/RsaI and DraI polymorphisms of CYP2E1and head and neck cancer risk: a meta-analysis based on 21 case-control studies
Authors
Kefu Tang
Yang Li
Zhao Zhang
Yunmin Gu
Yuyu Xiong
Guoyin Feng
Lin He
Shengying Qin
Publication date
01-12-2010
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2010
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/1471-2407-10-575

Other articles of this Issue 1/2010

BMC Cancer 1/2010 Go to the issue

Research article

A multicentric observational trial of pegylated liposomal doxorubicin for metastatic breast cancer

Research article

iASPP is over-expressed in human non-small cell lung cancer and regulates the proliferation of lung cancer cells through a p53 associated pathway

Research article

Modulation of SOCS protein expression influences the interferon responsiveness of human melanoma cells

Research article

Endometrial cancer in Puerto Rico: incidence, mortality and survival (1992-2003)

Research article

Combination of Dll4/Notch and Ephrin-B2/EphB4 targeted therapy is highly effective in disrupting tumor angiogenesis

Research article

Protection of p53 wild type cells from taxol by nutlin-3 in the combined lung cancer treatment
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Watch now

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine
Image Credits