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Published in:

01-12-2016

From transformation to metastasis: deconstructing the extracellular matrix in breast cancer

Authors: Shelly Kaushik, Michael W Pickup, Valerie M Weaver

Published in: Cancer and Metastasis Reviews | Issue 4/2016

Abstract

The extracellular matrix (ECM) is a guiding force that regulates various developmental stages of the breast. In addition to providing structural support for the cells, it mediates epithelial-stromal communication and provides cues for cell survival, proliferation, and differentiation. Perturbations in ECM architecture profoundly influence breast tumor progression and metastasis. Understanding how a dysregulated ECM can facilitate malignant transformation is crucial to designing treatments to effectively target the tumor microenvironment. Here, we address the contribution of ECM mechanics to breast cancer progression, metastasis, and treatment resistance and discuss potential therapeutic strategies targeting the ECM.

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Title: From transformation to metastasis: deconstructing the extracellular matrix in breast cancer
Authors: Shelly Kaushik
Michael W Pickup
Valerie M Weaver
Publication date: 01-12-2016
Publisher: Springer US
Published in: Cancer and Metastasis Reviews / Issue 4/2016
Print ISSN: 0167-7659
Electronic ISSN: 1573-7233
DOI: https://doi.org/10.1007/s10555-016-9650-0

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Keynote webinar | Spotlight on antibody–drug conjugates in cancer

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Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

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Prof. Fabrice Barlesi

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Keynote webinar | Spotlight on antibody–drug conjugates in cancer