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01-07-2021 | Coronary Heart Disease | Epidemiology

Association between physical activity and subsequent cardiovascular disease among 5-year breast cancer survivors

Authors: Kyae Hyung Kim, Seulggie Choi, Kyuwoong Kim, Jooyoung Chang, Sung Min Kim, Seong Rae Kim, Yoosun Cho, Yun Hwan Oh, Gyeongsil Lee, Joung Sik Son, Sang Min Park

Published in: Breast Cancer Research and Treatment | Issue 1/2021

Abstract

Purpose

To examine the association of physical activity among long-term breast cancer survivors on the occurrence of subsequent cardiovascular disease (CVD).

Methods

We investigated the risk of CVD among 39,775 breast cancer patients who were newly diagnosed in 2006 and survived until 2011 within the Korean National Health Insurance Service database. Patients were followed up from 5 years after breast cancer diagnosis to the date of CVD event, death, or December 31, 2018, whichever came earliest. Every 500 MET-mins/week correspond to 152, 125, and 62.5 min per week of light-, moderate-, and vigorous-intensity physical activity, respectively. Adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for CVD were calculated using Cox proportional hazards regression by physical activity levels.

Results

Compared with those with physical activity of 0 MET-min/week, those with 1–499 (aHR 0.82, 95% CI 0.69–0.98), 500–999 (aHR 0.75, 95% CI 0.63–0.90), and ≥ 1,000 (aHR 0.76, 95% CI 0.63–0.93) MET-min/week of PA had lower risk of CVD. Higher levels of PA were associated with lower risk of stroke (p for trend = 0.016). The benefits of PA on obese and overweight breast cancer survivors were smaller than those in normal weight survivors. The frequency of moderate-to-vigorous physical activity (MVPA) showed a reverse J-curve association with CVD, and the best benefit occurred in the 3–4 times MVPA per week group (aHR 0.59, 95% CI 0.46–0.74).

Conclusions

The study showed that even small amounts of PA may be beneficial in potentially decreasing the risk of CVD, CHD, and stroke in breast cancer survivors. Our result will be useful to prescribe and delivery exercise among long-term breast cancer survivors.

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Title: Association between physical activity and subsequent cardiovascular disease among 5-year breast cancer survivors
Authors: Kyae Hyung Kim
Seulggie Choi
Kyuwoong Kim
Jooyoung Chang
Sung Min Kim
Seong Rae Kim
Yoosun Cho
Yun Hwan Oh
Gyeongsil Lee
Joung Sik Son
Sang Min Park
Publication date: 01-07-2021
Publisher: Springer US
Keywords: Coronary Heart Disease
Stroke
Breast Cancer
Breast Cancer
Tamoxifen
Published in: Breast Cancer Research and Treatment / Issue 1/2021
Print ISSN: 0167-6806
Electronic ISSN: 1573-7217
DOI: https://doi.org/10.1007/s10549-021-06140-8

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