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Breast Cancer Research and Treatment
Published in: Breast Cancer Research and Treatment 3/2018

01-08-2018 | Review

Effects of physical exercise after treatment of early breast cancer: systematic review and meta-analysis

Authors: Frederico Soares Falcetta, Henrique de Araújo Vianna Träsel, Fernando Kude de Almeida, Mariana Rangel Ribeiro Falcetta, Maicon Falavigna, Daniela Dornelles Rosa

Published in: Breast Cancer Research and Treatment | Issue 3/2018

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Abstract

Purpose

Randomized clinical trials are inconclusive regarding the role of physical exercise in anthropometric measurements, quality of life, and survival in breast cancer patients. Our aim was to conduct a systematic review and meta-analysis to assess the effects of physical exercise on these outcomes in women who went through curative treatment of early-stage breast cancer.

Methods

Pubmed, Embase, Cochrane Library were searched for randomized clinical trial comparing physical exercise (counseling or structured programs with supervised/individualized exercise sessions) with usual care in women that went through for breast cancer treatment. Primary outcomes were overall survival and disease-free survival, while secondary outcomes were weight loss, body mass index, waist–hip ratio, percentage of body fat, and quality of life.

Results

We found 60 randomized clinical trials, only one of them showed mortality data; the HR for mortality was 0.45 (95% CI 0.21–0.97) for the intervention group when compared to the control group. Physical exercise was associated with weight reduction (− 1.36 kg, 95% CI − 2.51 to − 0.21, p = 0.02), lower body mass index (− 0.89 kg/m2, 95% CI − 1.50 to − 0.28, p < 0.01), and lower percentage of body fat (− 1.60 percentage points, 95% CI − 2.31 to − 0.88, p < 0.01). There was an increase in the quality of life (standardized mean difference of 0.45, 95% CI 0.20–0.69, p < 0.01).

Conclusions

The articles found had heterogeneous types of intervention, but they showed significant effects on anthropometric measures and quality of life. Among them, only one study had mortality as outcome and it showed physical exercise as a protective intervention. Despite these findings, publication bias and poor methodological quality were presented. Physical exercise should be advised for breast cancer survivors since it has no adverse effects and can improve anthropometrics measures and quality of life. PROSPERO registry: CRD42014008743.
Appendix
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Metadata
Title
Effects of physical exercise after treatment of early breast cancer: systematic review and meta-analysis
Authors
Frederico Soares Falcetta
Henrique de Araújo Vianna Träsel
Fernando Kude de Almeida
Mariana Rangel Ribeiro Falcetta
Maicon Falavigna
Daniela Dornelles Rosa
Publication date
01-08-2018
Publisher
Springer US
Published in
Breast Cancer Research and Treatment / Issue 3/2018
Print ISSN: 0167-6806
Electronic ISSN: 1573-7217
DOI
https://doi.org/10.1007/s10549-018-4786-y

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