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AIDS and Behavior
Published in: AIDS and Behavior 7/2017

01-07-2017 | Brief Report

Self-Report and Dry Blood Spot Measurement of Antiretroviral Medications as Markers of Adherence in Pregnant Women in Rural South Africa

Authors: Maria L. Alcaide, Shandir Ramlagan, Violeta J. Rodriguez, Ryan Cook, Karl Peltzer, Stephen M. Weiss, Sibusiso Sifunda, Deborah L. Jones

Published in: AIDS and Behavior | Issue 7/2017

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Abstract

Antiretroviral (ARV) adherence is essential to prevent mother-to-child transmission of HIV. This study compared self-reported adherence versus ARV detection in dried blood spots (DBS) among N = 392 HIV-infected pregnant women in South Africa (SA). Women completed two self-reported adherence measures [visual analog scale (VAS), AIDS Clinical Trials Group Adherence (ACTG)]. Adherence was 89% (VAS), 80% (ACTG), and 74% (DBS). Self-report measures marginally agreed with DBS (VAS: Kappa = 0.101, Area under the ROC curve (AUROC) = 0.543; ACTG: Kappa  = 0.081, AUROC = 0.538). Self-reported adherence was overestimated and agreement with DBS was poor. Validation of self-reported ARV adherence among pregnant HIV+ women in SA is needed.
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Metadata
Title
Self-Report and Dry Blood Spot Measurement of Antiretroviral Medications as Markers of Adherence in Pregnant Women in Rural South Africa
Authors
Maria L. Alcaide
Shandir Ramlagan
Violeta J. Rodriguez
Ryan Cook
Karl Peltzer
Stephen M. Weiss
Sibusiso Sifunda
Deborah L. Jones
Publication date
01-07-2017
Publisher
Springer US
Published in
AIDS and Behavior / Issue 7/2017
Print ISSN: 1090-7165
Electronic ISSN: 1573-3254
DOI
https://doi.org/10.1007/s10461-017-1760-3

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