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AIDS and Behavior
Published in: AIDS and Behavior 2/2017

01-02-2017 | Substantive Review

Motivations and Barriers to Treatment Uptake and Adherence Among People Living with HIV in Australia: A Mixed-Methods Systematic Review

Authors: Amary Mey, David Plummer, Shailendra Dukie, Gary D. Rogers, Maree O’Sullivan, Amber Domberelli

Published in: AIDS and Behavior | Issue 2/2017

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Abstract

In Australia, approximately 30% of people diagnosed with HIV are not accessing treatment and 8% of those receiving treatment fail to achieve viral suppression. Barriers limiting effective care warrant further examination. This mixed-methods systematic review accessed health and social sector research databases between November and December 2015 to identify studies that explored the perspective of people living with HIV in Australia. Articles were included for analysis if they described the experiences, knowledge, attitudes and beliefs, in relation to treatment uptake and adherence, published between January 2000 and December 2015. Quality appraisal utilised the Mixed Methods Appraisal Tool Version 2011. Seventy-two studies that met the inclusion criteria were reviewed. The interplay of lack of knowledge, fear, stigma, physical, emotional and social issues were found to negatively impact treatment uptake and adherence. Strategies targeting both the individual and the wider community are needed to address these barriers.
Footnotes
1
Medicare universal health insurance scheme refers to both the Pharmaceutical Benefits Scheme and Medicare Benefits Schedule.
 
2
Treatment uptake refers to individuals decisions to access ART.
 
3
Treatment adherence refers to the individuals’ behaviour in taking ART at the dose, frequency, duration and in a manner as prescribed.
 
Literature
1.
2.
3.
4.
5.
6.
7.
Cadosch D, Bonhoeffer S, Kouyos R. Assessing the impact of adherence to anti-retroviral therapy on treatment failure and resistance evolution in HIV. J R Soc Interface. 2012;9(74):2309–20.CrossRefPubMedPubMedCentral
8.
Fogarty L, Roter D, Larson S, Burke J, Gillespie J, Levy R. Patient adherence to HIV medication regimens: a review of published and abstract reports. Patient Educ Couns. 2002;46(2):93–108.CrossRefPubMed
9.
Nachega JB, Hislop M, Dowdy DW, Chaisson RE, Regensberg L, Maartens G. Adherence to nonnucleoside reverse transcriptase inhibitor-based HIV therapy and virologic outcomes. Ann Intern Med. 2007;146(8):564–73.CrossRefPubMed
10.
von Wyl V, Klimkait T, Yerly S, et al. Adherence as a predictor of the development of class-specific resistance mutations: the Swiss HIV cohort study. PLoS ONE. 2013;8(10):e77691.CrossRef
11.
Paterson DL, Swindells S, Mohr J, et al. Adherence to protease inhibitor therapy and outcomes in patients with HIV infection. Ann Intern Med. 2000;133(1):21–30.CrossRefPubMed
12.
13.
Gupta RK, Wainberg MA, Brun-Vezinet F, et al. Oral antiretroviral drugs as public health tools for HIV prevention: global implications for adherence, drug resistance, and the success of HIV treatment programs. J Infect Dis. 2013;207(Suppl 2):S101–6.CrossRefPubMedPubMedCentral
14.
15.
16.
17.
18.
19.
20.
21.
22.
Pope C, Ziebland S, Mays N. Analysing qualitative data. Qualitative Research in Health Care. Oxford: Blackwell Publishing Ltd; 2007. p. 63–81.
23.
24.
Pace R, Pluye P, Bartlett G, et al. Testing the reliability and efficiency of the pilot Mixed Methods Appraisal Tool (MMAT) for systematic mixed studies review. Int J Nurs Stud. 2012;49(1):47–53.CrossRefPubMed
25.
Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med. 2009;151(4):264–9.CrossRefPubMed
26.
Begley K, McLaws M, Ross MW, Gold J. Cognitive and behavioural correlates of non-adherence to HIV anti-retroviral therapy: theoretical and practical insight for clinical psychology and health psychology. Clin Psychol. 2008;12(1):9–17.CrossRef
27.
Brener L, Callander D, Slavin S, De Wit J. Experiences of HIV stigma: the role of visible symptoms, HIV centrality and community attachment for people living with HIV. AIDS Care. 2013;25(9):1166–73.CrossRefPubMed
28.
de Visser R, Ezzy D, Bartos M. Alternative or complementary? Nonallopathic therapies for HIV/AIDS. Altern Ther Health Med. 2000;6(5):44–52.PubMed
29.
Edmiston N, Passmore E, Smith DJ, Petoumenos K. Multimorbidity among people with HIV in regional New South Wales, Australia. Sex Health. 2015;12(5):425–32.CrossRefPubMed
30.
Fong R, Cheng AC, Vujovic O, Hoy JF. Factors associated with virological failure in a cohort of combination antiretroviral therapy-treated patients managed at a tertiary referral centre. Sex Health. 2013;10(5):442–7.CrossRefPubMed
31.
Gibbie T, Hay M, Hutchison CW, Mijch A. Depression, social support and adherence to highly active antiretroviral therapy in people living with HIV/AIDS. Sex Health. 2007;4(4):227–32.CrossRefPubMed
32.
Gold RS, Hinchy J, Batrouney CG. The reasoning behind decisions not to take up antiretroviral therapy in Australians infected with HIV. Int J STD AIDS. 2000;11(6):361–70.CrossRefPubMed
33.
Grierson J, de Visser R, Bartos M. More cautious, more optimistic: Australian people living with HIV/AIDS, 1997-1999. Int J STD AIDS. 2001;12(10):670–6.CrossRefPubMed
34.
Grierson JG, Misson SA, Pitts MK. Correlates of antiretroviral treatment breaks. HIV Med. 2004;5(1):34–9.CrossRefPubMed
35.
Grierson JW, Pitts MK, Misson S. Health and wellbeing of HIV-positive Australians: findings from the third national HIV Futures Survey. Int J STD AIDS. 2005;16(12):802–6.CrossRefPubMed
36.
Guy R, Wand H, McManus H, et al. Antiretroviral treatment interruption and loss to follow-up in two HIV cohorts in Australia and Asia: implications for ‘test and treat’ prevention strategy. AIDS Patient Care STDS. 2013;27(12):681–91.CrossRefPubMedPubMedCentral
37.
Herrmann S, McKinnon E, John M, et al. Evidence-based, multifactorial approach to addressing non-adherence to antiretroviral therapy and improving standards of care. Intern Med J. 2008;38(1):8–15.PubMed
38.
Herrmann SE, McKinnon EJ, Williams LJ, et al. Use of alcohol, nicotine and other drugs in the Western Australian HIV Cohort study. Sex Health. 2012;9(2):199–201.PubMed
39.
Hutton VE, Misajon R, Collins FE. Subjective wellbeing and ‘felt’ stigma when living with HIV. Qual Life Res. 2013;22(1):65–73.CrossRefPubMed
40.
McAllister J, Beardsworth G, Lavie E, MacRae K, Carr A. Financial stress is associated with reduced treatment adherence in HIV-infected adults in a resource-rich setting. HIV Med. 2013;14(2):120–4.CrossRefPubMed
41.
Pakenham KI, Rinaldis M. The role of illness, resources, appraisal, and coping strategies in adjustment to HIV/AIDS: the direct and buffering effects. Int J Behav Med. 2001;24(3):259–79.CrossRef
42.
Skevington SM, Norweg S, Standage M, Group WH. Predicting quality of life for people living with HIV: international evidence from seven cultures. AIDS Care. 2010;22(5):614–22.CrossRef
43.
Sternhell PS, Corr MJ. Psychiatric morbidity and adherence to antiretroviral medication in patients with HIV/AIDS. Aust N Z J Psychiatry. 2002;36(4):528–33.CrossRefPubMed
44.
Thorpe R, Grierson J, Pitts M. Gender differences in patterns of HIV service use in a national sample of HIV-positive Australians. AIDS Care. 2008;20(5):547–52.CrossRefPubMed
45.
Van De Ven P, Crawford J, Kippax S, Knox S, Prestage G. A scale of optimism-scepticism in the context of HIV treatments. AIDS Care. 2000;12(2):171–6.CrossRefPubMed
46.
Wilson KJ, Doxanakis A, Fairley CK. Predictors for non-adherence to antiretroviral therapy. Sex Health. 2004;1(4):251–7.CrossRefPubMed
47.
48.
Jenkin P, Koch T, Kralik D. The experience of fatigue for adults living with HIV. J Clin Nurs. 2006;15(9):1123–31.CrossRefPubMed
49.
McDonald K, Slavin S. My body, my life, my choice: practices and meanings of complementary and alternative medicine among a sample of Australian people living with HIV/AIDS and their practitioners. AIDS Care. 2010;22(10):1229–35.CrossRefPubMed
50.
McDonald K, Slavin S, Pitts MK, Elliott JH, Team HP. Chronic disease self-management by people with HIV. Qual Health Res. 2016;26(6):863–70.CrossRefPubMed
51.
Newman CE, Mao L, Persson A, et al. ‘Not until I’m absolutely half-dead and have to:’ accounting for non-use of antiretroviral therapy in semi-structured interviews with people living with HIV in Australia. AIDS Patient Care STDS. 2015;29(5):267–78.CrossRefPubMedPubMedCentral
52.
53.
Thorpe RD. Integrating biomedical and CAM approaches: the experiences of people living with HIV/AIDS. Health Sociol Rev. 2008;17(4):410–8.CrossRef
54.
Thorpe RD. ‘Doing’ chronic illness? Complementary medicine use among people living with HIV/AIDS in Australia. Sociol Health Illn. 2009;31(3):375–89.CrossRefPubMed
55.
Tsarenko Y, Polonsky MJ. ‘You can spend your life dying or you can spend your life living’: identity transition in people who are HIV-positive. Psychol Health. 2011;26(4):465–83.CrossRefPubMed
56.
57.
Goode M, McMaugh A, Crisp J, Wales S, Ziegler JB. Adherence issues in children and adolescents receiving highly active antiretroviral therapy. AIDS Care. 2003;15(3):403–8.CrossRefPubMed
58.
McDonald K, Bartos M, Rosenthal D. Australian women living with HIV/AIDS are more sceptical than men about antiretroviral treatment. AIDS Care. 2001;13(1):15–26.CrossRefPubMed
59.
Thomas S, Lam K, Piterman L, Mijch A, Komesaroff P. Complementary medicine use among people living with HIV/AIDS in Victoria, Australia: practices, attitudes and perceptions. Int J STD AIDS. 2007;18(7):453–7.CrossRefPubMed
60.
Fairley CK, Levy R, Rayner CR, et al. Randomized trial of an adherence programme for clients with HIV. Int J STD AIDS. 2003;14(12):805–9.CrossRefPubMed
61.
Grierson JW, Pitts MK, Thorpe RD. State of the (positive) nation: findings from the fourth national Australian HIV futures survey. Int J STD AIDS. 2007;18(9):622–5.CrossRefPubMed
62.
Grierson J, Koelmeyer RL, Smith A, Pitts M. Adherence to antiretroviral therapy: factors independently associated with reported difficulty taking antiretroviral therapy in a national sample of HIV-positive Australians. HIV Med. 2011;12(9):562–9.CrossRefPubMed
63.
Broom J, Sowden D, Williams M, Taing K, Morwood K, McGill K. Moving from viral suppression to comprehensive patient-centered care: the high prevalence of comorbid conditions and health risk factors in HIV-1-infected patients in Australia. J Int Assoc Physicians AIDS Care. 2012;11(2):109–14.CrossRef
64.
Kelly A. Living loss: an exploration of the internal space of liminality. Mortality. 2008;13(4):335–50.CrossRef
65.
Levy R, Rayner C, Fairley C, et al. Multidisciplinary HIV adherence intervention: a randomized study. AIDS Patient Care STDS. 2004;18(12):728–35.CrossRefPubMed
66.
Willis J. Panic at the discourse: Episodes from an analytic autoethnography about living with HIV. Illn Crises Loss. 2011;19(3):259–75.CrossRef
67.
Chow MY, Li M, Quine S. Client satisfaction and unmet needs assessment: evaluation of an HIV ambulatory health care facility in Sydney, Australia. Asia Pac J Public Health. 2012;24(2):406–14.CrossRefPubMed
68.
de Visser R, Grierson J. Use of alternative therapies by people living with HIV/AIDS in Australia. AIDS Care. 2002;14(5):599–606.CrossRefPubMed
69.
Newman CE, de Wit J, Persson A, et al. Understanding concerns about treatment-as-prevention among people with HIV who are not using antiretroviral therapy. AIDS Behav. 2015;19(5):821–31.CrossRefPubMed
70.
International Collaboration on HIV Optimism. HIV treatments optimism among gay men: an international perspective. J Acquir Immune Defic Syndr. 2003;32(5):545–50.CrossRef
71.
Knox S, Van De Ven P, Prestage G, Crawford J, Grulich A, Kippax S. Increasing realism among gay men in Sydney about HIV treatments: changes in attitudes over time. Int J STD AIDS. 2001;12(5):310–4.CrossRefPubMed
72.
Koelmeyer R, English DR, Smith A, Grierson J. Association of social determinants of health with self-rated health among Australian gay and bisexual men living with HIV. AIDS Care. 2014;26(1):65–74.CrossRefPubMed
73.
Zablotska I, Frankland A, Imrie J, et al. Current issues in care and support for HIV-positive gay men in Sydney. Int J STD AIDS. 2009;20(9):628–33.CrossRefPubMed
74.
Gold RS, Ridge DT. “I will start treatment when I think the time is right”: HIV-positive gay men talk about their decision not to access antiretroviral therapy. AIDS Care. 2001;13(6):693–708.CrossRefPubMed
75.
Holt M, Stephenson N. Living with HIV and negotiating psychological discourse. Health. 2006;10(2):211–31.CrossRefPubMed
76.
Holt M. Gay men and ambivalence about ‘gay community’: from gay community attachment to personal communities. Cult Health Sex. 2011;13(8):857–71.CrossRefPubMed
77.
Persson A, Race K, Wakeford E. HIV health in context: negotiating medical technology and lived experience. Health. 2003;7(4):397–415.CrossRef
78.
Persson A. Facing HIV: body shape change and the (in)visibility of illness. Med Anthropol. 2005;24(3):237–64.CrossRefPubMed
79.
Holt M, Murphy D, Callander D, et al. HIV-negative and HIV-positive gay men’s attitudes to medicines, HIV treatments and antiretroviral-based prevention. AIDS Behav. 2013;17(6):2156–61.CrossRefPubMed
80.
Down I, Prestage G, Triffitt K, Brown G, Bradley J, Ellard J. Recently diagnosed gay men talk about HIV treatment decisions. Sex Health. 2014;11(2):200–6.PubMed
81.
Murray JM, Prestage G, Grierson J, Middleton M, McDonald A. Increasing HIV diagnoses in Australia among men who have sex with men correlated with the growing number not taking antiretroviral therapy. Sex Health. 2011;8(3):304–10.CrossRefPubMed
82.
Munro I, Edward KL. The burden of care of gay male carers caring for men living with HIV/AIDS. Am J Mens Health. 2010;4(4):287–96.CrossRefPubMed
83.
Newman CE, Bonar M, Greville HS, Thompson SC, Bessarab D, Kippax SC. Barriers and incentives to HIV treatment uptake among Aboriginal people in Western Australia. AIDS. 2007;21(Suppl 1):S13–7.CrossRefPubMed
84.
Newman CE, Bonar M, Greville H, Thompson SC, Bessarab D, Kippax SC. ‘Everything is okay’: the influence of neoliberal discourse on the reported experiences of Aboriginal people in Western Australia who are HIV-positive. Cult Health Sex. 2007;9(6):571–84.CrossRefPubMed
85.
Thompson SC, Bonar M, Greville H, et al. “Slowed right down”: insights into the use of alcohol from research with Aboriginal Australians living with HIV. Int J Drug Policy. 2009;20(2):101–10.CrossRefPubMed
86.
Herrmann S, Wardrop J, John M, et al. The impact of visa status and Medicare eligibility on people diagnosed with HIV in Western Australia: a qualitative report. Sex Health. 2012;9(5):407–13.CrossRefPubMed
87.
Korner H. ‘If I had my residency I wouldn’t worry’: negotiating migration and HIV in Sydney, Australia. Ethn Health. 2007;12(3):205–25.CrossRefPubMed
88.
Woolley I, Bialy C. Visiting friends and relatives may be a risk for non-adherence for HIV-positive travellers. Int J STD AIDS. 2012;23(11):833–4.CrossRefPubMed
89.
Ayton DR, Guy RJ, Woolley IJ, Hellard ME. Cambodian-born individuals diagnosed with HIV in Victoria: epidemiological findings and health service implications. Sex Health. 2007;4(3):209.CrossRefPubMed
90.
Korner H. Late HIV diagnosis of people from culturally and linguistically diverse backgrounds in Sydney: the role of culture and community. AIDS Care. 2007;19(2):168–78.CrossRefPubMed
91.
Korner H. Negotiating cultures: disclosure of HIV-positive status among people from minority ethnic communities in Sydney. Cult Health Sex. 2007;9(2):137–52.CrossRefPubMed
92.
Giles ML, Hellard ME, Lewin SR, O’Brien ML. The work of women when considering and using interventions to reduce mother-to-child transmission (MTCT) of HIV. AIDS Care. 2009;21(10):1230–7.CrossRefPubMed
93.
McDonald K, Kirkman M. HIV-positive women in Australia explain their use and non-use of antiretroviral therapy in preventing mother-to-child transmission. AIDS Care. 2011;23(5):578–84.CrossRefPubMed
94.
Persson A, Richards W. From closet to heterotopia: a conceptual exploration of disclosure and ‘passing’ among heterosexuals living with HIV. Cult Health Sex. 2008;10(1):73–86.CrossRefPubMed
95.
Persson A. Reflections on the Swiss Consensus Statement in the context of qualitative interviews with heterosexuals living with HIV. AIDS Care. 2010;22(12):1487–92.CrossRefPubMed
96.
Persson A. “I don’t blame that guy that gave it to me”: contested discourses of victimisation and culpability in the narratives of heterosexual women infected with HIV. AIDS Care. 2014;26(2):233–9.CrossRefPubMed
97.
Cummins D, Millar KH. Experiences of HIV-positive women in Sydney. Australia. J Assoc Nurses AIDS Care. 2004;15(3):70–4.CrossRefPubMed
98.
Giles ML, McDonald AM, Elliott EJ, et al. Variable uptake of recommended interventions to reduce mother-to-child transmission of HIV in Australia, 1982–2005. Med J Aust. 2008;189(3):151–4.PubMed
99.
Lemoh CN, Baho S, Grierson J, Hellard M, Street A, Biggs BA. African Australians living with HIV: a case series from Victoria. Sex Health. 2010;7(2):142–8.CrossRefPubMed
100.
Persson A. The undoing and doing of sexual identity among heterosexual men with HIV in Australia. Men Masc. 2012;15(3):311–28.CrossRef
101.
Korner H, Hendry O, Kippax S. Safe sex after post-exposure prophylaxis for HIV: intentions, challenges and ambivalences in narratives of gay men. AIDS Care. 2006;18(8):879–87.CrossRefPubMed
102.
103.
Metadata
Title
Motivations and Barriers to Treatment Uptake and Adherence Among People Living with HIV in Australia: A Mixed-Methods Systematic Review
Authors
Amary Mey
David Plummer
Shailendra Dukie
Gary D. Rogers
Maree O’Sullivan
Amber Domberelli
Publication date
01-02-2017
Publisher
Springer US
Published in
AIDS and Behavior / Issue 2/2017
Print ISSN: 1090-7165
Electronic ISSN: 1573-3254
DOI
https://doi.org/10.1007/s10461-016-1598-0

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