Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
AIDS and Behavior
Published in: AIDS and Behavior 3/2014

01-03-2014 | Original Paper

Hazardous and Harmful use of Alcohol and/or Other Drugs and Health Status Among South African Patients Attending HIV Clinics

Authors: R. Kader, S. Seedat, R. Govender, J. R. Koch, C. D. Parry

Published in: AIDS and Behavior | Issue 3/2014

Login to get access

Abstract

There is growing recognition of the influence of substance use, particularly alcohol use, on HIV disease progression. This study investigated how hazardous/harmful use of alcohol and drugs impacts the health status of 1503 patients attending HIV clinics. Of the sample, 37 % indicated hazardous/harmful drinking and 13 % indicated a drug problem. Hazardous/harmful use of alcohol and drugs was significantly related to health status, with participants using substances more likely to have TB-positive status (χ2 = 4.30, p < 0.05), less likely to be on ARVs (χ2 = 9.87, p < 0.05) and having lower CD4 counts (t = 4.01, p < 0.05). Structural equation modelling confirmed the centrality of hazardous/harmful use of alcohol as a direct and indirect determinant of disease progression. Based on these findings it is recommended that patients attending HIV clinics be routinely screened for problematic alcohol and/or drug use, with strong emphasis on ensuring ARV adherence in those with problematic alcohol use.
Literature
1.
2.
Department of Health. National Antenatal Sentinel HIV and Syphilis Prevalence in South Africa, 2009. Pretoria: Department of Health; 2010.
3.
Shisana O, Rehle T, Simbayi LC, et al. South African National HIV prevalence, incidence, behaviour and communication survey 2008: A turning tide among teenagers? Cape Town: HSRC Press; 2009.
4.
Townsend L, Rosenthal SR, Parry CDH, Zembe Y, Mathews C, Flisher AJ. Associations between alcohol misuse and risks for HIV infection among men who have multiple female sexual partners in Cape Town, South Africa. AIDS Care. 2010;22(12):1544–54.PubMedCrossRef
5.
Parry CDH, Pithey AL. Risk behaviour and HIV among drug using populations in South Africa. Afr J Drug Alcohol Stud. 2006;5(2):140–57.
6.
Herman AL, Stein DJ, Seedat S, Heeringa SG, Moomal H, Williams DR. The South African Stress and Health (SASH) study: 12-month and lifetime prevalence of common mental disorders. S Afr Med J. 2009;99(5):339–44.PubMedCentralPubMed
7.
Dada S, Plüddemann A, Parry C et al. Monitoring alcohol and drug abuse trends in South Africa (July 1996–December 2011). SACENDU Research Brief, 2012; 15(1): 1–15. Medical Research Council of South Africa.
8.
Barroso J, Sandelowski M. Substance abuse in HIV positive women. J Assoc Nurses AIDS Care. 2004;15(5):48–59.PubMedCrossRef
9.
Hendershot CS, Stoner SA, Pantalone DW, Simoni JM. Alcohol use and antiretroviral adherence: review and meta-analysis. J Acquir Immune Defic Syndr. 2009;52:180–202.PubMedCentralPubMedCrossRef
10.
Molina PE, Happel KI, Zang P, Kolls JK, Nelson S. Focus on: alcohol and the immune system. Alcohol Res Health. 2010;33(1):97–108.PubMedCentralPubMed
11.
12.
Myer L, Smit J, Le Roux L, Parker S, Stein D, Seedat S. Common mental disorders among HIV-infected individuals in South Africa: prevalence, predictors, and validation of brief psychiatric rating scales. AIDS Patient Care and STDs. 2008;22(2):147–58.PubMedCrossRef
13.
Olley BO, Gxamza F, Seedat S, et al. Psychopathology and coping in recently diagnosed HIV/AIDS patients-the role of gender. S Afr Med J. 2003;93(12):928–31.PubMed
14.
Freeman M, Nkomo N, Kafaar Z, Kelly K. Mental disorders in people living HIV/Aids in South Africa. S Afr J Psychiatry. 2008;38(3):489–500.
15.
Goar SG, Audu MD, Agbir MT, Dochalson. Prevalence and socio-demographic correlates of alcohol use disorders among HIV patients. Afr J Drug Alcohol Stud. 2011;10(11):11–6.
16.
Yunusa MA, Obembe A, Ibrahim T, Njoku CH. Prevalence and specific psychosocial factors associated with substance use and psychiatric morbidity among patients with HIV infection at Usmanu Danfodiyo University Teaching Hospital, Sokoto State, Nigeria. Afr J Drug Alcohol Stud. 2011;10(1):11–6.
17.
Sacktor NC, Wong M, Nakasujja N, et al. The International HIV Dementia Scale: a new rapid screening test for HIV dementia. AIDS. 2005;19:1367–74.PubMed
18.
Berghuis JP, Uldall KK, Lalonde B. Validity of two scales in identifying HIV associated dementia. J Acquir Immune Defic Syndr. 1999;21(2):134–40.PubMed
19.
Babor TF, Higgins-Biddle JC, Saunders JB, Monteiro MG. AUDIT The Alcohol Use Disorders Identification Test: Guidelines for use in primary care. 2nd ed. Geneva: World Health Organization Department of Mental Health and Substance Dependence; 2001.
20.
Peltzer K, Davids SA, Njuho P. Alcohol use and problem drinking in South Africa: findings from a national population-based survey. Afr J Psychiatry. 2011;14:30–7.CrossRef
21.
Peltzer K, Naidoo P, Matseke G, Zuma K. Screening and brief interventions for hazardous and harmful alcohol use among patients with active tuberculosis attending primary care clinics in South Africa: a cluster randomized controlled trial protocol. BMC Public Health. 2011;4(11):394–402.CrossRef
22.
Julia L, Peltzer K, Matseke G. Prevalence of alcohol use and associated factors in pregnant antenatal care attendees in Mpumalanga, South Africa. J Psychol Afr. 2011;21(4):567–72.
23.
Berman AH, Bergman H, Palmstierna T, Schlyter F. DUDIT manual the drug use disorders identification test. London: Karolinska Institutet Department of Clinical Neuroscience; 2005.
24.
Field A. Discovering statistics using SPSS. 3rd ed. London: SAGE Publications Ltd; 2009.
25.
26.
Turner BJ, Fleishman JA, Wenger N, et al. Effects of drug abuse and mental disorders on use and type of antiretroviral therapy in HIV-infected persons. J Gen Intern Med. 2001;16(9):625–33.PubMedCentralPubMedCrossRef
27.
Thomas B, Suhadev M, Mani J, et al. Feasibility of an alcohol intervention programme for TB patients with alcohol use disorder (AUD)—a qualitative study from Chennai, South India. PLoS One. 2011;6(11):e27752.PubMedCentralPubMedCrossRef
28.
Suhadev M, Thomas BE, Sakthivel R, et al. Alcohol use disorders (AUD) among tuberculosis patients: a study from Chennai, South India. PLoS One. 2011;6(5):e19485.PubMedCentralPubMedCrossRef
29.
Azar MW, Springer SA, Meyer JP, Altice FL. A systematic review of the impact of alcohol use disorders on HIV treatment outcomes, adherence to antiretroviral therapy and health care utilization. Drug Alcohol Depend. 2010;112:178–93.PubMedCentralPubMedCrossRef
30.
Malta M, Magnanini MMF, Strathdee SA, Bastos FI. Adherence to antiretroviral therapy among HIV-infected drug users: a meta-analysis. AIDS Behav. 2008. doi: 10.​1007/​s10461-008-9489-7.
31.
Kader R, Seedat S, Koch JR, Parry CDH. A preliminary investigation of the AUDIT and DUDIT in comparison to biomarkers for alcohol and drug use among HIV-infected clinic attendees in Cape Town, South Africa. Afr J Psychiatry. 2012;15:346–51.CrossRef
32.
Peretti-Watel P, Spire B, Lert F, Obadai Y. The Vespa Group. Drug use patterns and adherence to treatment among HIV-positive patients: evidence from a large sample of French outpatients (ANRS-EN 12-VESPA 2003). Drug Alcohol Depend. 2006;82(1):71–9.CrossRef
33.
Parry CDH, Rehm J, Morojele NK. Is there a causal relationship between alcohol and HIV? Implications for policy, practice and future research. Afr J Drug Alcohol Stud. 2010;9(2):81–91.
34.
Parry CDH, Ferreira-Borges C, Poznyak V, Lonnroth K, Rehm J. The international study on alcohol and infectious diseases: three priorities for research. Addiction. 2012;108:1–2.PubMedCrossRef
Metadata
Title
Hazardous and Harmful use of Alcohol and/or Other Drugs and Health Status Among South African Patients Attending HIV Clinics
Authors
R. Kader
S. Seedat
R. Govender
J. R. Koch
C. D. Parry
Publication date
01-03-2014
Publisher
Springer US
Published in
AIDS and Behavior / Issue 3/2014
Print ISSN: 1090-7165
Electronic ISSN: 1573-3254
DOI
https://doi.org/10.1007/s10461-013-0587-9

Other articles of this Issue 3/2014

AIDS and Behavior 3/2014 Go to the issue

Brief Report

Associations Between Alcohol Use, Other Psychosocial Factors, Structural Factors and Antiretroviral Therapy (ART) Adherence Among South African ART Recipients

Original Paper

Smoking Behaviors in a Community-Based Cohort of HIV-Infected Indigent Adults

Original Paper

Transitions in Latent Classes of Sexual Risk Behavior Among Young Injection Drug Users Following HIV Prevention Intervention

Original Paper

Associations of Sex Trafficking History with Recent Sexual Risk among HIV-Infected FSWs in India

Original Paper

Cervical Cancer Screening Adherence among HIV-Positive Female Smokers from a Comprehensive HIV Clinic

Original Paper

Client Perspectives on Design and Implementation of a Couples-Based Intervention to Reduce Sexual and Drug Risk Behaviors Among Female Sex Workers and Their Noncommercial Partners in Tijuana and Ciudad Juárez, México
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Pediatric Cardiology Video

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

Cardiopulmonary Comorbidity Video

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Valvular Heart Disease Video

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

Watch now

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits