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01-08-2010 | Original Paper

Adherence to Antiretroviral Therapy Among HIV-Infected Drug Users: A Meta-Analysis

Authors: Monica Malta, Monica M. F. Magnanini, Steffanie A. Strathdee, Francisco I. Bastos

Published in: AIDS and Behavior | Issue 4/2010

Abstract

We conducted a meta-analysis of studies assessing adherence to highly active antiretroviral therapy (HAART) and a qualitative systematic review of factors associated with better HAART outcomes among HIV+ drug users (DU). Thirty-eight studies were considered, which analyzed 14,960 patients (11,394 HIV+ DU, 76.2%). Overall adherence (pooled percent of DU classified as adherent in each study) was 0.60 (95% CI: 0.52–0.68), similar to levels identified by studies conducted with HIV+ patients who are not drug users. Time frame used to measure adherence was an independent predictor of inter-study heterogeneity. The systematic review identified better HAART outcomes among former DU, those with less severe psychiatric conditions, those receiving opioid substitution therapy and/or psychosocial support. Patients initiating HAART with lower viral load and higher CD4 counts, and those without co-infections also had better treatment outcomes. Our findings suggest that HIV+ DU tend to be inappropriately assumed to be less adherent and unlikely to achieve desirable treatment outcomes, when compared to their non-DU cohort.

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Title: Adherence to Antiretroviral Therapy Among HIV-Infected Drug Users: A Meta-Analysis
Authors: Monica Malta
Monica M. F. Magnanini
Steffanie A. Strathdee
Francisco I. Bastos
Publication date: 01-08-2010
Publisher: Springer US
Published in: AIDS and Behavior / Issue 4/2010
Print ISSN: 1090-7165
Electronic ISSN: 1573-3254
DOI: https://doi.org/10.1007/s10461-008-9489-7

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STEP AAG HeroTeaserCollection image/© Tarek / Generated with AI / Stock.adobe.com, ACC 2024 Pediatric and Congenital Heart Disease: Year in Review/© 2024 American College of Cardiology, ACC 2024 Pulmonary Vascular Disease: Year in Review/© 2024 American College of Cardiology, ACC 2024 Valvular Heart Disease: Year in Review/© 2024 American College of Cardiology, ACC 2024 HF and Cardiomyopathies: Year in Review/© 2024 American College of Cardiology, Woman out walking/© Seventyfour / stock.adobe.com (symbolic image with model), Woman checking smartwatch /© saltdium / stock.adobe.com (symbolic image with model), Cardiac catheterization/© Damian / stock.adobe.com

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Other articles of this Issue 4/2010

Transportation Costs Impede Sustained Adherence and Access to HAART in a Clinic Population in Southwestern Uganda: A Qualitative Study

Hazardous Drinking and HIV Sexual Risk Behaviors Among Injection Drug Users in Developing and Transitional Countries

Factors Associated with HIV Testing Among Public Sector Clinic Attendees in Johannesburg, South Africa

Numeracy Skills Explain Racial Differences in HIV Medication Management

Lack of Association between Retrospectively Collected Pharmacy Refill Data and Electronic Drug Monitoring of Antiretroviral Adherence

Prevalence of HIV Infection and Prior HIV Testing among Young Men Who have Sex with Men. The Baltimore Young Men’s Survey

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