Top

Japanese Journal of Ophthalmology

Published in:

01-01-2015 | Clinical Investigation

Noninvasive diagnostics supporting system for choroidal melanoma: a pilot study

Authors: Ori Kameyama, Yoshihiko Usui, Keisuke Kimura, Atsushi Nakamura, Takayuki Sota, Hiroshi Goto

Published in: Japanese Journal of Ophthalmology | Issue 1/2015

Abstract

Purpose

To examine the usefulness of a near-infrared hyperspectral imager (NIR-HSI) system in discriminating uveal melanoma from other intraocular tumors.

Method

The NIR-HSI, which had been developed as a screening system for age-related macular degeneration, was used to measure near-infrared hyperspectral data (NIR-HSD) of a lesion located at the ocular fundus of 17 Japanese patients, including 5 with choroidal melanoma and 12 with other intraocular tumors. The index was derived from each NIR-HSD. Non-parametric statistical analysis was performed.

Results

Diagnostic accuracy of 94.1 % was achieved when the threshold value of the index was set to minimize the average value of false-positive and -negative fractions.

Conclusions

The NIR-HSI system is useful as a noninvasive diagnostic supporting system for choroidal melanoma.

Singh AD, Topham A. Incidence of uveal melanoma in the United States: 1973–1997. Ophthalmology. 2003;110:956–61.PubMedCrossRef

Kaneko A. Incidence of malignant melanoma of the eye in Japan. Rinsho Ganka. 1979;33:941–7 (in Japanese).

Collaborative Ocular Melanoma Study Group. The COMS randomized trial of iodine 125 brachytherapy for choroidal melanoma: V. Twelve-year mortality rates and prognosis factors: COMS report no. 28. Arch Ophthalmol. 2006;124:1684–93.CrossRef

Hawkins BS, Collaborative Ocular Melanoma Study Group. The Collaborative Ocular Melanoma Study (COMS) randomized trial of pre-enucleation radiation of large choroidal melanoma: IV. Ten-year mortality finding and prognostic factors. COMS report number 24. Am J Ophthalmol. 2004;138:936–51.PubMedCrossRef

Scheidler J, Leinsinger G, Kirsch CM, Scheiffarth OF, Stefani FH, Riedel KG. Immunoimaging of choroidal melanoma: assessment of its diagnostic accuracy and limitations in 101 cases. Br J Opthalmol. 1992;76:457–60.CrossRef

Holman BL, Zimmerman RE, Schapiro JR, Kaplan ML, Jones AG, Hill TC. Biodistribution and dosimetry of N-Isopropyl-p-[¹²³I] iodoamphetamine in the primate. J Nucl Med. 1983;24:922–31.PubMed

Holman BL, Wick MM, Kaplan ML, Hill TC, Lee RG, Wu JL, et al. The relationship of the eye uptake of N-isopropyl-p-[¹²³I] iodoamphetamine to melanin production. J Nucl Med. 1984;25:315–9.PubMed

Goto H, Usui M, Ishii I. Efficacy of (123)N-isopropyl-p-[(123)I]-iodoamphetamine single photon emission computed tomography for the diagnosis of uveal malignant melanoma. Am J Ophthalmol. 2001;132:937–9.PubMedCrossRef

Goto H. Clinical efficacy of 123I-IMP SPECT for the diagnosis of malignant uveal melanoma. Int J Clin Oncol. 2004;9:74–8.PubMedCrossRef

10.

Sou R, Oku N, Ohguro N, Hibino S, Fujikado T, Tano Y. The clinical role of n-isopropyl-p-[¹²³I]-iodoamthetamine single photon emission computed tomography in the follow-up of choroidal melanoma after radiotherapy. Jpn J Ophthalmol. 2004;48:54–8.PubMedCrossRef

11.

Yoshimura M, Kanesaka N, Saito K, Koizumi K, Tokuuye K, Goto H. Diagnosis of uveal malignant melanoma by a new semiquantitative assessment of N-isopropyl-p-[¹²³I]-iodoamphetamine. Jpn J Ophthalmol. 2011;55:148–54.PubMedCrossRef

12.

Morimoto K, Yoshimura M, Goto H, Koizumi K, Abe K. Semiquantitative evaluation of uveal malignant melanoma with N-isopropyl-p-[¹²³I]-iodoamphetamine (I-123 IMP). J Tokyo Med Univ. 2007;65:137–43.

13.

Shields CL, Shields JA, Kiratli H, De Potter P, Cater JR. Risk factors for growth and metastasis of small choroidal melanocytic lesion. Ophthalmology. 1995;102:1351–61.PubMedCrossRef

14.

Shields CL, Cater J, Shields JA, Singh AD, Santos MCM, Carvalho C. Combination of clinical factors predictive of growth of small choroidal melanocytic tumors. Arch Ophthalmol. 2000;118:360–4.PubMedCrossRef

15.

Shields CL, Furuta M, Berman EL, Zahler JD, Hoberman DM, Dinh DH, et al. Choroidal nevus transformation into melanoma. Arch Ophthalmol. 2009;127:981–7.PubMedCrossRef

16.

Stolz W, Riemann A, Cognetta AB, Pillet L, Abmayr W. ABCD rule of dermatoscopy: a new practical method for early recognition of malignant melanoma. Eur J Dermatol. 1994;4:521–7.

17.

Nachbar F, Stolz W, Merkle T, Cognetta AB, Vogt T, Landthaler M, et al. The ABCD rule of dermatoscopy: high prospective value in the diagnosis of doubtful melanocytic skin lesions. J Am Acad Dermatol. 1994;30:551–9.PubMedCrossRef

18.

Menzies SW, Ingvar C, Crotty KA, McCarthy WH. Frequency and morphologic characteristics of invasive melanomas lacking specific surface microscopic features. Arch Dermatol. 1996;132:1178–82.PubMedCrossRef

19.

Menzies SW, Ingvar C, McCarthy WH. A sensitivity and specificity analysis of the surface microscopy features of invasive melanoma. Melanoma Res. 1996;6:55–62.PubMedCrossRef

20.

Argenziano G, Fabbrocini G, Carli P, De Giorgi V, Sammarco E, Delfino M. Epiluminescence microscopy for the diagnosis of doubtful melanocytic skin lesions: comparison of the ABCD rule of dermatoscopy and a new 7-point checklist based on pattern analysis. Arch Dermatol. 1998;134:1563–70.PubMedCrossRef

21.

Nagaoka T, Nakamura A, Okutani H, Kiyohara Y, Sota T. A possible melanoma discrimination index based on hyperspectral data: a pilot study. Skin Res Technol. 2012;18:301–9.PubMedCrossRef

22.

Nagaoka T, Nakamura A, Okutani H, Kiyohara Y, Koga H, Saida T, et al. Hyperspectroscopic screening of melanoma on acral volar skin. Skin Res Technol. 2013;19:e290–6.PubMedCrossRef

23.

Vo-Dinh T, Stokes DL, Wabuyele MB, Martin ME, Song JM, Jagannathan R, et al. A hyperspectral imaging system for in vivo optical diagnostics. Hyperspectral imaging basic principles, instrumental systems, and applications of biomedical interest. IEEE Eng Med Biol Mag. 2004;23:40–9.PubMedCrossRef

24.

Khoobehi B, Beach JM, Kawano H. Hyperspectral imaging for measurements of oxygen saturation in the optic nerve head. Invest Ophthalmol Vis Sci. 2004;45:1464–72.PubMedCrossRef

25.

Yamauchi Y, Kemma H, Goto H, Nakamura A, Nagaoka T, Sota T. Novel automated method for screening age-related macular degeneration. Jpn J Ophthalmol. 2012;56:577–83.PubMedCrossRef

26.

World Medical Association. Declaration of Helsinki: ethical principles for medical research involving human subjects. http://www.wma.net/en/30publications/10policies/b3/index.html. Accessed 29 Jan 2014.

27.

Kruse FA, Lefkoff AB, Boardman JW, Heidebrecht KB, Shapiro AT, Barloon PJ, et al. The spectral image processing system (SIPS)–interactive visualization and analysis of imaging spectrometer data. Remote Sens Environ. 1993;44:145–63.CrossRef

28.

Shields JA, Mashayekhi A, Seong RA, Shields CL. Pseudomelanomas of the posterior uveal tract. Retina. 2005;25:767–71.PubMedCrossRef

Title: Noninvasive diagnostics supporting system for choroidal melanoma: a pilot study
Authors: Ori Kameyama
Yoshihiko Usui
Keisuke Kimura
Atsushi Nakamura
Takayuki Sota
Hiroshi Goto
Publication date: 01-01-2015
Publisher: Springer Japan
Published in: Japanese Journal of Ophthalmology / Issue 1/2015
Print ISSN: 0021-5155
Electronic ISSN: 1613-2246
DOI: https://doi.org/10.1007/s10384-014-0351-3

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Noninvasive diagnostics supporting system for choroidal melanoma: a pilot study

Abstract

Purpose

Method

Results

Conclusions

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Purpose

Method

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 1/2015

Orbital blowout fracture location in Japanese and Chinese patients

Development and evaluation of a visual aid using see-through display for patients with retinitis pigmentosa

Diagnostic criteria for IgG4-related ophthalmic disease

Ocular adnexal IgG4-related disease: clinical features, outcome, and factors associated with response to systemic steroids

Difference in correspondence between visual field defect and inner macular layer thickness measured using three types of spectral-domain OCT instruments

Development and validation of new diagnostic criteria for acute retinal necrosis