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Magnetic Resonance Materials in Physics, Biology and Medicine

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Open Access 01-02-2020 | Magnetic Resonance Imaging | Research Article

Comparison of multi-delay FAIR and pCASL labeling approaches for renal perfusion quantification at 3T MRI

Authors: Anita A. Harteveld, Anneloes de Boer, Suzanne Lisa Franklin, Tim Leiner, Marijn van Stralen, Clemens Bos

Published in: Magnetic Resonance Materials in Physics, Biology and Medicine | Issue 1/2020

Abstract

Objective

To compare the most commonly used labeling approaches, flow-sensitive alternating inversion recovery (FAIR) and pseudocontinuous arterial spin labeling (pCASL), for renal perfusion measurement using arterial spin labeling (ASL) MRI.

Methods

Multi-delay FAIR and pCASL were performed in 16 middle-aged healthy volunteers on two different occasions at 3T. Relative perfusion-weighted signal (PWS), temporal SNR (tSNR), renal blood flow (RBF), and arterial transit time (ATT) were calculated for the cortex and medulla in both kidneys. Bland–Altman plots, intra-class correlation coefficient, and within-subject coefficient of variation were used to assess reliability and agreement between measurements.

Results

For the first visit, RBF was 362 ± 57 and 140 ± 47 mL/min/100 g, and ATT was 0.47 ± 0.13 and 0.70 ± 0.10 s in cortex and medulla, respectively, using FAIR; RBF was 201 ± 72 and 84 ± 27 mL/min/100 g, and ATT was 0.71 ± 0.25 and 0.86 ± 0.12 s in cortex and medulla, respectively, using pCASL. For both labeling approaches, RBF and ATT values were not significantly different between visits. Overall, FAIR showed higher PWS and tSNR. Moreover, repeatability of perfusion parameters was better using FAIR.

Discussion

This study showed that compared to (balanced) pCASL, FAIR perfusion values were significantly higher and more comparable between visits.

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Title: Comparison of multi-delay FAIR and pCASL labeling approaches for renal perfusion quantification at 3T MRI
Authors: Anita A. Harteveld
Anneloes de Boer
Suzanne Lisa Franklin
Tim Leiner
Marijn van Stralen
Clemens Bos
Publication date: 01-02-2020
Publisher: Springer International Publishing
Keywords: Magnetic Resonance Imaging
Magnetic Resonance Imaging
Published in: Magnetic Resonance Materials in Physics, Biology and Medicine / Issue 1/2020
Print ISSN: 0968-5243
Electronic ISSN: 1352-8661
DOI: https://doi.org/10.1007/s10334-019-00806-7

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Comparison of multi-delay FAIR and pCASL labeling approaches for renal perfusion quantification at 3T MRI

Abstract

Objective

Methods

Results

Discussion

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Objective

Methods

Results

Discussion

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