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Magnetic Resonance Materials in Physics, Biology and Medicine

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01-02-2020 | Magnetic Resonance Imaging | Research Article

Cardiorenal sodium MRI in small rodents using a quadrature birdcage volume resonator at 9.4 T

Authors: Laura Boehmert, Helmar Waiczies, Andre Kuehne, Celal Oezerdem, Sonia Waiczies, Ludger Starke, Min-Chi Ku, Andreas Pohlmann, Erdmann Seeliger, Thoralf Niendorf

Published in: Magnetic Resonance Materials in Physics, Biology and Medicine | Issue 1/2020

Abstract

Objective

Design, implementation, evaluation and application of a quadrature birdcage radiofrequency (RF) resonator tailored for renal and cardiac sodium (²³Na) magnetic resonance imaging (MRI) in rats at 9.4 T.

Materials and methods

A low pass birdcage resonator (16 rungs, d_in = 62 mm) was developed. The transmission field (B₁⁺) was examined with EMF simulations. The scattering parameter (S-parameter) and the quality factor (Q-factor) were measured. For experimental validation B₁⁺-field maps were acquired with the double-angle method. In vivo sodium imaging of the heart (spatial resolution: (1 × 1 × 5) mm³) and kidney (spatial resolution: (1 × 1 × 10) mm³) was performed with a FLASH technique.

Results

The RF resonator exhibits RF characteristics, transmission field homogeneity and penetration that afford ²³Na MR in vivo imaging of the kidney and heart at 9.4 T. For the renal cortex and medulla a SNRs of 8 and 13 were obtained and a SNRs of 14 and 15 were observed for the left and right ventricle.

Discussion

These initial results obtained in vivo in rats using the quadrature birdcage volume RF resonator for ²³Na MRI permit dedicated studies on experimental models of cardiac and renal diseases, which would contribute to translational research of the cardiorenal syndrome.

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Title: Cardiorenal sodium MRI in small rodents using a quadrature birdcage volume resonator at 9.4 T
Authors: Laura Boehmert
Helmar Waiczies
Andre Kuehne
Celal Oezerdem
Sonia Waiczies
Ludger Starke
Min-Chi Ku
Andreas Pohlmann
Erdmann Seeliger
Thoralf Niendorf
Publication date: 01-02-2020
Publisher: Springer International Publishing
Keywords: Magnetic Resonance Imaging
Magnetic Resonance Imaging
Published in: Magnetic Resonance Materials in Physics, Biology and Medicine / Issue 1/2020
Print ISSN: 0968-5243
Electronic ISSN: 1352-8661
DOI: https://doi.org/10.1007/s10334-019-00810-x

At a glance: The STEP trials

Springer Medicine

Cardiorenal sodium MRI in small rodents using a quadrature birdcage volume resonator at 9.4 T

Abstract

Objective

Materials and methods

Results

Discussion

At a glance: The STEP trials

Springer Medicine

Abstract

Objective

Materials and methods

Results

Discussion

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