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Magnetic Resonance Materials in Physics, Biology and Medicine

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01-08-2020 | Magnetic Resonance Imaging | Research Article

Comparison between synthetic and conventional magnetic resonance imaging in patients with multiple sclerosis and controls

Authors: Francesca Di Giuliano, Silvia Minosse, Eliseo Picchi, Girolama Alessandra Marfia, Valerio Da Ros, Massimo Muto, Mario Muto, Chiara Adriana Pistolese, Andrea Laghi, Francesco Garaci, Roberto Floris

Published in: Magnetic Resonance Materials in Physics, Biology and Medicine | Issue 4/2020

Abstract

Objectives

Synthetic magnetic resonance imaging (SyMRI) allows to obtain different weighted-images using the multiple-dynamic multiple-echo sequence lasting 6 min. The aim is to compare quantitatively and qualitatively synthetic- and conventional MRI in patients with multiple sclerosis (MS) and controls assessing the contrast (C), the signal to noise ratio (SNR), and the contrast to noise ratio (CNR). We evaluated the lesion count and lesion-to-white matter contrast (\({\text{C}}_{{\text{l } - \text{ WM}}} {)}\) in the MS patients.

Methods and methods

51 patients underwent synthetic- and conventional MRI. Qualitative analysis was evaluated by assigning scores to all synthetic- and conventional MRI sequences by two neuroradiologists. Lesions were counted in MS patients both in the conventional- and synthetic T2-FLAIR. Regions of interest were placed in the cerebrospinal fluid, in the white- and grey matter. For the sequences were evaluated: C, CNR, and SNR.

Results

Synthetic T2-FLAIR images are qualitatively inferior. C and CNR were significantly higher in synthetic T1W and T2W images compared to conventional images, but not for T2-FLAIR. The SNR value was always lower in synthetic images than in conventional ones.

Conclusions

SyMRI can be used in clinical practice because it has a similar diagnostic accuracy which reduces the scanning time compared to the conventional one. However, synthetic T2-FLAIR images need to be improved.

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Title: Comparison between synthetic and conventional magnetic resonance imaging in patients with multiple sclerosis and controls
Authors: Francesca Di Giuliano
Silvia Minosse
Eliseo Picchi
Girolama Alessandra Marfia
Valerio Da Ros
Massimo Muto
Mario Muto
Chiara Adriana Pistolese
Andrea Laghi
Francesco Garaci
Roberto Floris
Publication date: 01-08-2020
Publisher: Springer International Publishing
Keywords: Magnetic Resonance Imaging
Magnetic Resonance Imaging
Multiple Sclerosis
Published in: Magnetic Resonance Materials in Physics, Biology and Medicine / Issue 4/2020
Print ISSN: 0968-5243
Electronic ISSN: 1352-8661
DOI: https://doi.org/10.1007/s10334-019-00804-9

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Springer Medicine

Comparison between synthetic and conventional magnetic resonance imaging in patients with multiple sclerosis and controls

Abstract

Objectives

Methods and methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Objectives

Methods and methods

Results

Conclusions

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